2LZM,4PK0,1K28


Conserved Protein Domain Family
T4-like_lys
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cd00735: T4-like_lys 
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bacteriophage T4-like lysozymes
Bacteriophage T4-like lysozymes hydrolyze the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc) in peptidoglycan heteropolymers of prokaryotic cell walls. Members include a variety of bacteriophages (T4, RB49, RB69, Aeh1), as well as Dictyostelium.
Links
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Statistics
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PSSM-Id: 381597
Aligned: 14 rows
Threshold Bit Score: 166.395
Created: 6-Mar-2002
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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catalyticsugar binding
Conserved site includes 3 residues -Click on image for an interactive view with Cn3D
Feature 1: catalytic residues [active site], 3 residue positions
Conserved feature residue pattern:E D TClick to see conserved feature residue pattern help
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                 #        #     #                                                       
2LZM_A         2 NIFEMLRIDEGLRLKIYKDTeGYYTIGIGHLLTkspslnaaks---eldkaigrncNGVITKD------EAEKLFNQDVD 72  Enterobacteria ...
4PK0_A         2 NIFEMLRIDEGLRLKIYKDTeGYYTIGIGHLLTkspslnaaks---eldkaigrntNGVITKD------EAEKLFNQDVD 72  Actinoplanes te...
AHN81253       3 QIIPLLNFEEGYREKPYIDTeGYPTVACGIRIGpkga----------------slsNYTFTVPr----dVGDAWLESFVK 62  Salmonella ente...
AAQ17989       1 MLAQMLKQDEGYKESVYWDTeGYPTIGIGHLILrkktkdmge------inrelsshIGRIVNDgkisgaEVLALFERDLA 74  Aeh1
BAB90980     180 TIEKMLRGDEGYREKWYLDSeGYPTIGIGHLIIykktsdlgiinnelsklvgrevtNGRLTAE------EVSKVFADDIE 253 RB49
KFD21223       6 AIIPLLRQEEGVRYTPYLDSlGYPTTGVGFKLGpqga----------------sikNYTFRLSd----tTIDAWLSDTVS 65  Yokenella regen...
WP_023248370   6 EIFSLLKMEEGVSHKPYIDSlGYPTVGVGFKLGpqga----------------slkNYTFCLTd----nVIEAWLQENID 65  Salmonella ente...
EXU74492       3 QIVALLKYEEGYRDVPFIDTqGYPTVGCGIKIGpkga----------------pltSYIFRVPi----vVGELWMQNLVM 62  Erwinia malloti...
EWD17076       2 TLYEMLRFDEGEKLKLYKDTeGYWTIGIGHLVTknpskeqaia---cldkelnrvtSGVISKS------ESEQLFNLDIS 72  Klebsiella pneu...
WP_026641108   4 ELTRLLRGDEGEVLHAYQDHlGFWTIGVGRLIDkr--------------------kGGGISKA------ESALLLSNDIA 57  Bordetella petrii

Feature 1                                                                                        
2LZM_A        73 AAVRGILRnaklkpvYDSLDAVRRCALINMVFQMGETGVAgFTNSLRMLQQKRWDEAAvNLAKSRWYNQTPNRAKRVITT 152 Enterobacteria ...
4PK0_A        73 AAVRGILRnaklkpvYDSLDAVRRAALINMVFQMGETGVAgFTNSLRMLQQKRWDEAAvNLAKSRWYNQTPNRAKRVITT 152 Actinoplanes te...
AHN81253      63 TTISKMNTnppivaaMKSCNPARRDILISMAYQMGVSGLAgFKNTLAMVAEGNYAGAAnGMLSSLWAKQTPNRAKRHAEV 142 Salmonella ente...
AAQ17989      75 AIQRTMMNvpalasvYVELDAVRKTAIENMVFQMGAIGVSkFPGMLRALKAKDWNMAYkQALDSTWAKQTPNRANRVASV 154 Aeh1
BAB90980     254 KTRRDMRKhpriapvYNKCNASRRMALENMAFQMGVGGLGkFKNSLAAMLAEEWKQAYdGLRQSVWANQTPGRSSRVSKI 333 RB49
KFD21223      66 GVQAGMRKnseisiaLAHCNQPRQDILTSMAYQMGVAGLSgFHQMLAAISAEEWDEAVaQMLNSSWAKQTPSRAQRQSAV 145 Yokenella regen...
WP_023248370  66 RVYRSMQRnekinraLLYSNSVRADILISMAYQMGVNGLAgFNNMLVAITGQDWNNAAdEMRRSIWAKQTPERAERHATV 145 Salmonella ente...
EXU74492      63 SKIYDMKQqpqlaqaLSQCNQPRTDILYSMAYQLGVTGLCaFRQMLAAVTKGDFSSAAdNMLNSLWAKQTPARAARHAAV 142 Erwinia malloti...
EWD17076      73 RALRDIERsel-ssiYIQTNGPRRAALVNLTFQLGLAGVLkFRKMIQYLKVGNYEAAAdEGLDSKWARQTPNRARRVSEV 151 Klebsiella pneu...
WP_026641108  58 EKEAELDRcv---pwWRQLPDARRAVLLAMAFQMGVDGLLsFKTTLARVKAGDCDGAArGMLASLWARQTPERAHRMSEQ 134 Bordetella petrii

Feature 1                
2LZM_A       153 FRTGTWDA 160 Enterobacteria phage T4
4PK0_A       153 FRTGTWDA 160 Actinoplanes teichomyceticus
AHN81253     143 MRTGEMAA 150 Salmonella enterica subsp. enterica serovar Tennessee str. TXSC_TXSC08-19
AAQ17989     155 LKLGSYAP 162 Aeh1
BAB90980     334 ILTGNLES 341 RB49
KFD21223     146 LRSGLWQP 153 Yokenella regensburgei ATCC 49455
WP_023248370 146 IETGQWAP 153 Salmonella enterica
EXU74492     143 MRDGNWDS 150 Erwinia mallotivora
EWD17076     152 IRTGTFSS 159 Klebsiella pneumoniae UCI 42
WP_026641108 135 MRTNVWHF 142 Bordetella petrii

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