Conserved Protein Domain Family
aceF

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PRK11854: aceF 
pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated
Statistics
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PSSM-Id: 236999
Aligned: 113 rows
Threshold Bit Score: 717.552
Created: 9-Dec-2010
Updated: 2-Oct-2020
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
237785299   1 MAFSVEMPELGesVTEGTVTTWLKQVGDTVAVDEPLLEVSTDKVDTEIPSPVAGVLTKIIADEDDTVEVGEVIAEIG--E 78 
70734012    1 MSELIRVPDIG--SGEGEVIELFVKVGDRIEADQSILTLESDKASMEVPAPKAGVIKSLKVKLGDRLKEGDELLELE--V 76 
77456690    1 MSELIRVPDIG--SGEGEVIELFVKVGDRIEADQSILTLESDKASMEVPAPKAGVIKSLKVKLGDRLKEGDELLELEveG 78 
68535782    1 MAYSVEMPELGesVTEGTVTQWLKKVGDKVSVDEPLLEVSTDKVDTEIPSPASGVLLKIIADEDDTVDVGAVIAEIG--E 78 
19553408    1 MAFSVEMPELGesVTEGTITQWLKSVGDTVEVDEPLLEVSTDKVDTEIPSPVAGVILEIKAEEDDTVDVGGVIAIIGdaD 80 
62391046    1 MAFSVEMPELGesVTEGTITQWLKSVGDTVEVDEPLLEVSTDKVDTEIPSPVAGVILEIKAEEDDTVDVGGVIAIIGdaD 80 
145296168   1 MAFSVEMPELGesVTEGTITQWLKSVGDTVEVDEPLLEVSTDKVDTEIPSPVAGVILEIKAEEDDTVDVGGVIAIIG--D 78 
146305612   1 MSELIRVPDLG---GEGEVIELLVKVGDRIEAEQSVLTLESDKASMEVPSPKAGVVKEIKVKIGDRLKEGDELLVLE--V 75 
172040927   1 MAQSVEMPELGesVTEGTITQWLKKVGDKVEVDEPLLEVSTDKVDTEIPSPVAGILLKVMAEEDDTIEVGSVIAEIG--E 78 
226946510   1 MSEIIRVPDIG---GDGEVIELLVKTGDLIEVEQGLVVLESAKASMEVPSPKAGVVKSVSVKLGDKLKEGDAIIELE--P 75 
237785299  79 EgddtSSddsgasepsdsgsGDSGAEEKSSS--------EGEKSQkssdsgSSGSGPGEATDVEMPELGesVTEGTITQW 150
70734012   77 EgaaaAA-------------PAAAPAAKAEA--------KPAAAPaaasapAAAPAAASVQQVHVPDIGs-SGKAQIIEI 134
77456690   79 AaqaaP--------------APAAAPAAKAE--------AAPAAApapaapAAAPAAASVQQVHVPDIGs-SGKAQIIEI 135
68535782   79 EgeepSGsdads---ssdddSSDAAEDSSES--------GSESSDnsgaesGSGSASGEAEDVTMPELGesVTEGTITQW 147
19553408   81 EtpanEA-------------PADEAPAPAEEeepvkeepKKEAAP------EAPAATGAATDVEMPELGesVTEGTITQW 141
62391046   81 EtpanEA-------------PADEAPAPAEEeepvkeepKKEAAP------EAPAATGAATDVEMPELGesVTEGTITQW 141
145296168  79 AdetpANeapad---eapapAEEEEPVKEEP--------KKEAAP------EAPAATGAATDVEMPELGesVTEGTITQW 141
146305612  76 EgaaqAApa----------pKAEAAPAQAPQ--------AAAPAAa----pAAAATGSSVQDVHVPDIGs-SAKGKVIEI 132
172040927  79 EdeapSSddegdd-ssnedeAADSSDEEAED--------SSEDSSs----dDASEGSGEGEDVTMPELGesVTEGTITQW 145
226946510  76 AagaaAApae--------aaAVPAAPTQAVD--------EAEAPSpg--asATPAPAAASQEVRVPDIGs-AGKARVIEV 136
237785299 151 LKSVGDEVEVDEPLLEVSTDKVDTEIPSPVAGTLVEVLAEEDDTVDVGSVIARIGDANaassssddssDDK-AESTEaeE 229
70734012  135 QVKVGDKVEADQSLITLESDKASMEIPSPAAGVVKAISVKLNDEVGTGDLILDLEVAG----------AAApAAAPAqaA 204
77456690  136 QVKVGDTVEADQSLITLESDKASMEIPSPAAGVVKAISVKLNDEVGTGDLILDLEVAG--------------AAAPA--A 199
68535782  148 LKKVGDKVEVDEPLLEVSTDKVDTEIPSPVAGTLVEILANEDDTVDVGAVIARIGDEGaaksgssdssDSSdSSSSKadE 227
19553408  142 LKAVGDTVEVDEPLLEVSTDKVDTEIPSPVAGTIVEILADEDDTVDVGAVIARIGDAN--------------AAAAP--A 205
62391046  142 LKAVGDTVEVDEPLLEVSTDKVDTEIPSPVAGTIVEILADEDDTVDVGAVIARIGDAN--------------AAAAP--A 205
145296168 142 LKAVGDTVEVDEPLLEVSTDKVDTEIPSPVAGTIVEILADEDDTVDVGAVIARIGDAN----------AAAaPAEEE--A 209
146305612 133 MVKVGDRIEADQSLLTLESDKASMEIPAPAAGVVEQVLVKLDDEIGTGDLILKLKVEG----------AAPaAAAPAaaP 202
172040927 146 LKSVGDKVEVDEPLLEVSTDKVDTEIPSPVAGTLVEILAEEDDTVEVGDVIARIGDGEakp----akkEEPkAEEPEetE 221
226946510 137 LVKAGDQVQAEQSLIVLESDKASMEIPSPASGVVESVAIQLNAEVGTGDLILTLRTTG----------AQAqPTAPA--A 204
237785299 230 ESpaeDDEQA----------------NASSsedkgangsGSGEATDVEMPELGesVTEGTITQWLKSVGDEVEVDEPLLE 293
70734012  205 AP---AAAAA----------------PAPAaap---aapVADSVQDIHVPDIGs-AGKAKIIEVLVKAGDSVEADQSLIT 261
77456690  200 AApaqAAAPA----------------AAPApaaa-paapVADSVQDIHVPDIGs-AGKAKIIEVLVKAGDSVEADQSLIT 261
68535782  228 SEskeSSEPS----------------DSSSaessdnsgsGSGEAEDVTMPELGesVTEGTITQWLKKVGDKVEVDEPLLE 291
19553408  206 EE---EAAPAeeeepvkeepkkeaapEAPA---------ATGAATDVEMPELGesVTEGTITQWLKAVGDTVEVDEPLLE 273
62391046  206 EE---EAAPAeeeepvkeepkkeaapEAPA---------ATGAATDVEMPELGesVTEGTITQWLKAVGDTVEVDEPLLE 273
145296168 210 APaeeEAAPAeeeepvkeepkkeaapEAPA---------ATGAATDVEMPELGesVTEGTITQWLKAVGDTVEVDEPLLE 280
146305612 203 AQ---AAAPA----------------AAPApaa----apSGSSVQDVRVPDIGs-SAKGKVIEIMVKAGDSIEADQSLLT 258
172040927 222 DE---DAEASsedasedtsadessddSASE---------GSGEDEDVTMPELGesVTEGTITQWLKSVGDKVEVDEPLLE 289
226946510 205 AA---AASPA----------------PAPLa-------pAAAGPQEVKVPDIGs-AGKARVIEVLVKAGDQVQAEQSLIV 257
237785299 294 VSTDKVDTEIPSPIAGTLVEVLAEEDDTVDVGSVIARIGDANAAS----------------------------------- 338
70734012  262 LESDKASMEIPSPAAGVVESVSIKLDDEVGTGDLILKLKVKGAAPa---------------------------------- 307
77456690  262 LESDKASMEIPSPAAGVVESISIKLDDEVGTGDLILKLKVKGAAPa---------------------------------- 307
68535782  292 VSTDKVDTEIPSPVAGTLVEILANEDDTVDVGAVIARIGDEAAAKsgs------------------------------sk 341
19553408  274 VSTDKVDTEIPSPVAGTIVEILADEDDTVDVGAVIARIGDANAAAa---------------------------------- 319
62391046  274 VSTDKVDTEIPSPVAGTIVEILADEDDTVDVGAVIARIGDANAAAa---------------------------------- 319
145296168 281 VSTDKVDTEIPSPVAGTIVEILADEDDTVDVGAVIARIGDANAAAa---------------------------------- 326
146305612 259 LESDKASMEIPSPAAGVVEEVLVKLDDEIGTGDLILKLKVAGSASa---------------------------------- 304
172040927 290 VSTDKVDTEIPSPVAGTLVEILAEEDDTVEVGDVIARIGDGSGKPskkeepkkeksedkssekakakdeqksekkddskd 369
226946510 258 LESDKASMEIPSPAAGVVESVAVQLNAEVGTGDQILTLRVAGAAPa---------------------------------- 303
237785299 339 -SSSddeadkkaeETKSEEKSEPEpSKSEKAEetkdtsdsATSSETAspKASSAsapdreepatrpstkVNTGGKLPYVT 417
70734012  308 -AAPa--------PAAAPSAPAPAaAAAPAAA--------APAAAPAaaPAKPG--------------------AKVHAG 350
77456690  308 -AAP---------APAAAAAPSAPaPAAAPAA--------AAPAAAApvAAPAK------------------PGAKVHAG 351
68535782  342 sDES---------VTEDKAEPKAEeKKAEAKQ--------AEEKAEAktETKSEpkaeakpskpaaqqsKPAEGNLPYVT 404
19553408  320 -PAEee------aAPAEEEEPVKEePKKEEPKkeepkkeaATTPAAAsaTVSAS------------------GDNVPYVT 374
62391046  320 -PAEee------aAPAEEEEPVKEePKKEEPKkeepkkeaATTPAAAsaTVSAS------------------GDNVPYVT 374
145296168 327 -PAEeea----apAEEEDPVKEEPkKEEPKk--------eAATTPAA--ASATV---------------SASGDNVPYVT 376
146305612 305 -PAPaqasqevhrVPEGAAPEVAAeVRAIASL--------SAAAAEVanAPKRD-------------------GAKVHAG 356
172040927 370 eQKS---------EKKDSGKDKAAaAREAAREkaakttarPNVADRGekSGSAG---------------EPSGDNLPYVT 425
226946510 304 -AAP---------APAAAPAKPAAaPAAAAPA--------PAPVGAP-----------------------SRNGAKVHAG 342
237785299 418 PLVRKLAEKHSVDLTTVEGSGVGGRIRKQDVLAAAE--KAKAAPDTS---STsgNADekpAQDGPRAAWSTkrVDPKKAE 492
70734012  351 PAVRQLAREFGVELSAVGASGPHGRILKEDVQVYVK--AMMQKAKEA---PAagGAT----GGAGIPPIPV--VDFSRFG 419
77456690  352 PAVRQLAREFGVELSAVGASGPHGRILKEDVQTYVK--AMMQKAKEA---PAaaAGA---TGGAGIPPIPV--VDFSRFG 421
68535782  405 PLVRKLAEKHGVDLSSVEGTGVGGRIRKQDILAAAE--GTSASGSSA---KSasPAG------PRASSYK---VDPAKQE 470
19553408  375 PLVRKLAEKHGVDLNTVTGTGIGGRIRKQDVLAAAN-------GEAA---PAeaAAP--------VSAWSTksVDPEKAK 436
62391046  375 PLVRKLAEKHGVDLNTVTGTGIGGRIRKQDVLAAAN-------GEAA---PAeaAAP--------VSAWSTksVDPEKAK 436
145296168 377 PLVRKLAEKHGVDLNTVTGTGIGGRIRKQDVLAAAN--DEAAPAEAAapvSAwsTKS----------------VDPEKAK 438
146305612 357 PAVRQLARDFGVELADIAGTGPKGRILKEDVQAYVK--AMMHKAKAA---PQaaAAA---TGGAGIPPIPA--VDFSKFG 426
172040927 426 PLVRKLAEKNNVDLSKVTGTGVGGRIRKQDVLAAAEgeDITTGAKTNlpaGPraSAH-------------K--VDPDKQE 490
226946510 343 PAVRQLAREFGVELAAINSTGPRGRILKEDVQAYVK--AMMQKAKEA---PAagAAS---GA--GIPPIPP--VDFAKYG 410
237785299 493 LIGTTQkVNRIRSLTASKTLESLHSSAQLTQVHEVDMTDVAALRK-ASKPAFKEKYGVNLTYLPFFAKAVVEALISHPNV 571
70734012  420 EIEEVP-MTRLMQAGAANLHRSWLNVPHVTQFDSADITELEAFRVaQKAVAEKA--GVKLTILPLLLKSCAHLLKELPDF 496
77456690  422 EIEEVP-MTRLMQVGAANLHRSWLNVPHVTQFDSADITELEAFRTaQKSVAEKA--GVKLTILPLLLKSCAHLLKELPDF 498
68535782  471 LRGTTKkVSRIREITAKTTLDSLHAAAQLTQVHEVDMTRVAELRK-ANKQAFADKHGVNLTYLPFFAKAAVEALISHPNV 549
19553408  437 LRGTTQkVNRIREITAMKTVEALQISAQLTQLHEVDMTRVAELRK-KNKPAFIEKHGVNLTYLPFFVKAVVEALVSHPNV 515
62391046  437 LRGTTQkVNRIREITAMKTVEALQISAQLTQLHEVDMTRVAELRK-KNKPAFIEKHGVNLTYLPFFVKAVVEALVSHPNV 515
145296168 439 LRGTTQkVNRIREITAKKTVEALQISAQLTQLHEVDMTRVAELRK-KNKPAFIEKHGVNLTYLPFFVKAVVEALVSHPNV 517
146305612 427 EIEEVA-MTRLMQVGAANLHRSWLNVPHVTQFDSADITDLEAFRVaQKAVAEKA--GVKLTVLPLLLKACAHLLKELPDF 503
172040927 491 LIGTTQkVNRIREITARTTLESLRNSAQLTQVHEVDMTLVADLRA-KSKKAFQDAHGVNLTFLPFFAKAAVEALISHPNV 569
226946510 411 EIEEVP-MTRLMQIGATNLHRSWLNVPHVTQFESADITELEAFRVaQKAVAEKA--GVKLTVLPLLLKACAYLLKELPDF 487
237785299 572 NASYNAETKEMTYHDKVNLGIAVDTEAGLLSPVIHNAQDMTLPELAAAIADIADRARTNKLKPNDLTGGTFTITNIGSEG 651
70734012  497 NSSLAPSGKAIIRKKYVNIGFAVDTPDGLLVPVIKNVDQKSLLQLAAEAASLAEKARTKKLSADEMQGACFTISSLGHIG 576
77456690  499 NSSLAPSGKAIIRKKYVNIGFAVDTPDGLLVPVIKNVDQKSLLQLAAEAASLAEKARTKKLSSDEMQGACFTISSLGHIG 578
68535782  550 NASYNAQTKEMTYHEQVNLGIAVDTEAGLLSPVIHNAQDMSLPELAQAIVDIADRARNKKLKPNDLSGGTFTITNIGSEG 629
19553408  516 NASFNAKTKEMTYHSSVNLSIAVDTPAGLLTPVIHDAQDLSIPEIAKAIVDLADRSRNNKLKPNDLSGGTFTITNIGSEG 595
62391046  516 NASFNAKTKEMTYHSSVNLSIAVDTPAGLLTPVIHDAQDLSIPEIAKAIVDLADRSRNNKLKPNDLSGGTFTITNIGSEG 595
145296168 518 NASYNAKTKEMTYHSSVNLSIAVDTPAGLLTPVIHDAQDLSIPEIAKAIVDLADRSRNNKLKPNDLSGGTFTITNIGSEG 597
146305612 504 NSSLAPSGKALIRKKYVHIGFAVDTPDGLLVPVIKNVDQKSLLQLAGEAAALADKARTKKLSADDMQGACFTISSLGHIG 583
172040927 570 NASYNAETKEMTYHDRVNLSIAVDTEDGLLSPVIHDAQDLSLPELAKAIADIADRARNKKLKPNDLAGGTFTITNIGSEG 649
226946510 488 NSSLAPSGQALIRKKYVHIGFAVDTPDGLLVPVIRNVDQKSLLQLAAEAAELAEKARSKKLGADAMQGACFTISSLGHIG 567
237785299 652 ALTDTPILVPPQAAMMGTGAIVKRPsvvptSDGSDAIAIRQMVLLPLTYDHQIVDGADAGRFMTTVRDRLETANfesDLD 731
70734012  577 GTGFTPIVNAPEVAILGVSKATIQP-----VWDGKAFQPKLMLPLSLSYDHRVINGAAAARFTKRLSDLLADIR---TIL 648
77456690  579 GTGFTPIVNAPEVAILGVSKATIQP-----VWDGKAFQPKLMLPLSLSYDHRVINGAAAARFTKRLSDLLADIR---TIL 650
68535782  630 ALTDTPILVPPQAAMIGTGAIVKRPvv-lsEDEGEAIAIRQMVFLPMTYDHQVIDGADAGRFMSTLRDRLENSDfteDLE 708
19553408  596 ALSDTPILVPPQAGILGTGAIVKRPvv-itEDGIDSIAIRQMVFLPLTYDHQVVDGADAGRFLTTIKDRLETANfegDLQ 674
62391046  596 ALSDTPILVPPQAGILGTGAIVKRPvv-itEDGIDSIAIRQMVFLPLTYDHQVVDGADAGRFLTTIKDRLETANfegDLQ 674
145296168 598 ALSDTPILVPPQAGILGTGAIVKRPvv-itEDGIDSIAIRQMVFLPLTYDHQVVDGADAGRFLTTIKDRLETANfegDLQ 676
146305612 584 GTGFTPIVNAPEVAILGVSKATMQP-----VWDGKAFQPKLMLPLSLSYDHRVINGAAAARFTQRLSQLLADIR---TIL 655
172040927 650 ALTDTPILVPPQAAMVGTGAIVKRPvv-ltEDENEAIAIRDMVFLPMTYDHQVIDGADAGRFMSTLRDRLEKGDfedDLE 728
226946510 568 GTAFTPIVNAPEVAILGVSKASMQP-----VWDGKAFQPRLMLPLSLSYDHRVINGAAAARFTKRLGDLLADIR---AIL 639
237785299 732 L 732
70734012  649 L 649
77456690  651 L 651
68535782  709 L 709
19553408  675 L 675
62391046  675 L 675
145296168 677 L 677
146305612 656 L 656
172040927 729 L 729
226946510 640 L 640
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