3KVT


Conserved Protein Domain Family
BTB_Shaw-like

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cd18416: BTB_Shaw-like 
Click on image for an interactive view with Cn3D
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel protein Shaw
Shaw, also called Shaw2, is a voltage-gated potassium channel in Drosophila. It mediates transmembrane potassium transport in excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a tetrameric potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. Shaw is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.
Statistics
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PSSM-Id: 349723
Aligned: 8 rows
Threshold Bit Score: 249.879
Created: 14-Sep-2017
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Zn binding siteputative
Conserved site includes 4 residues -Click on image for an interactive view with Cn3D
Feature 1: Zn binding site [ion binding site], 4 residue positions
Conserved feature residue pattern:H C C CClick to see conserved feature residue pattern help
Evidence:
  • Comment:Zn binding occur in a HX(5)CX(20)CC sequence motif that is highly conserved among all Shab, Shaw and Shal subfamily members, but is not found in Shaker subfamily members
  • Structure:3KVT: Aplysia californica Kv3.1 binds a Zn2+ ion.
  • Citation:PMID 9886290

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                       #     #       
3KVT_A      4 ENRVIINVGGIRHETYKATLKKIPATRLSRLTEGMLNYDPVLNEYFFDRHPGVFAQIINYYRSGKLHYPTDVCGPLFEEE 83  California sea hare
17569273   36 DERIVLNVGGVRHETYQATLKKIPATRLSRLTPSLANFDPLLNEYFFDRHPAVFAMILNYYRTGKLHYPTDVCGPLFEEE 115 Caenorhabditis ele...
P17972      9 ENRVVLNVGGIRHETYKATLKKIPATRLSRLTEALANYDPILNEYFFDRHPGVFAQVLNYYRTGKLHYPTDVCGPLFEEE 88  Drosophila simulans
ELT88551    5 ENRVILNVGGIRHETYKATLKKIPATRLSRLTEALANYDPVLNEYFFDRHPGVFAQVLNYYRTGKLHYPTDVCGPLFEEE 84  Capitella teleta
BAE75955   12 DNRVVLNIGGIRFETYKATLKKIPATRLSRLTEALANYDPVLNEYFFDRHPGVFAQILNYYRTGKLHYPTNVCGPLFEEE 91  Nephila clavata
EFX84931    4 ENRIILNVGGFRFETYRTTLKKIPATRLSRLTEALANYDPVLNEFFFDRHPGVFAQILNYYRTGKLHYPTNVCGPLFEEE 83  common water flea
CDS36228   28 NNRVILNVGGVRHETYKSTLKKIPATRLSRLTEALANYDPLLNEYFFDRHPAVFAQVLNYYRTGKLHYPVDVCGPLFEEE 107 Echinococcus multi...
EEC08450    6 ENRVVLNVGGIRHETYKATLKKIPATRLSRLTEALANYDPVLNEYFFDRHPGVFGQILNYYRTGKLHYPTDVCGPLFEEE 85  black-legged tick
Feature 1                  ##                 
3KVT_A     84 LEFWGLDSNQVEPCCWMTYTAHRDTQETLAVL 115 California sea hare
17569273  116 LQYWGLDASDTEPCCWMQLLHAKDTQETLAVL 147 Caenorhabditis elegans
P17972     89 LEFWGLDSNQVEPCCWMTYTQHRDTQETLAVL 120 Drosophila simulans
ELT88551   85 LEFWGLDANQVEPCCWMTYTTHRDTQETLQIL 116 Capitella teleta
BAE75955   92 LEFWGLDANQVEPCCWMTYTVHRDTQSTLAIL 123 Nephila clavata
EFX84931   84 LEFWGLDANQVEPCCWMTYTVHRDTQTTLAIL 115 common water flea
CDS36228  108 LQFWGLDSNQVEPCCWMTYTAHRDTQATLHIL 139 Echinococcus multilocularis
EEC08450   86 LEFWGLDANQVEPCCWMTYTQHRDTQETLAVL 117 black-legged tick

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