2QM1


Conserved Protein Domain Family
ASKHA_NBD_ROK_BsGLK-like

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cd24062: ASKHA_NBD_ROK_BsGLK-like 
nucleotide-binding domain (NBD) of Bacillus subtilis glucokinase (GLK) and similar proteins
Glucokinase (EC 2.7.1.2), also called glucose kinase, acts as an ATP-dependent kinase that phosphorylates glucose using ATP as a donor to give glucose-6-phosphate and ADP. It is highly specific for glucose. Glucokinases are found in invertebrates and microorganisms. They belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.
Statistics
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PSSM-Id: 466912
Aligned: 12 rows
Threshold Bit Score: 396.661
Created: 13-Dec-2022
Updated: 27-Apr-2023
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site include 1 residue -Click on image for an interactive view with Cn3D
Feature 1: catalytic site [active site], 1 residue position
Conserved feature residue pattern:DClick to see conserved feature residue pattern help
Evidence:
  • Comment:the catalytic Asp acts as a catalytic base.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                     
2QM1_A      7 KIIGIDLGGTTIKFAILTtdGVVQQKWSIETniledgkHIVPSIIESIRHRIDLYnxkkedfVGIGXGTPGSvdiEKGTV 86  Enterococcus faeca...
Q9KCZ4      5 WYVGVDVGGTTIKMAFLTtaGEIVDKWEIPTnkqdggaLITTNIADALDKRLSGHhksksdlIGIGLGAPGFiemDTGFI 84  Halalkalibacterium...
P54495      5 WFAGIDLGGTTIKLAFINqyGEIQHKWEVPTdkt--gdTITVTIAKTIDSKLDELqkpkhiiKYIGMGAPGPvdmAAGVV 82  Bacillus subtilis ...
SIA50684    4 KIIGIDLGGTSVKFAILTqeGEIQEKWSIKTnildegsHIVDDMIESIQHRLNLLglsatdfQGIGMGSPGVvdrENGTV 83  Mycobacteroides ab...
TDL91567    5 WLVGADIGGTTIKMAFINqnGEIIYKWEIPTninekgkNIPKEMAKSIDQTLSELgqekqklIGIGVGAPGPvnlGNGSI 84  Vibrio vulnificus
PWU03044    5 WLVGVDIGGTTIKMALISlnGDLIYSWEVDTdkrgrgrYIPTTIARSIEQKLNELkqtknrlIGIGVGAPGPvnvEDGSI 84  Bacteroidetes bact...
TGV30068    4 IIVGVDVGGTAIKMALITpnGELVAKIQEPTpvaegedGVLQKIAGMTRALLHEHgytleqaSGIGVGIPGPidaKNGIV 83  Mesorhizobium sp. ...
GBU10962    4 RLIGIDVGGTTIKIAFLTwsGEIISKWEIPTntvnkgeNILTDISESIKQKIVDLsmnladfHAAGVGVPGPvqlNVGYL 83  Erysipelotrichacea...
PSL08988   14 IAVGVDVGGTTVKLGFFSpeGELIQKWEIPTdressgaNIIPDIASSIQKTLEKGaykledvIGVGLDVPGPv-qPTGYV 92  Fusobacterium navi...
AFM40074    4 VIMGIDLGGTSIKLGLVNisGQIVQSLEWPTpknksyhEVIAAFERMSEQLLRESsyswrdiLGVGIGIPGFldfSTGSV 83  Desulfosporosinus ...
PTQ57440    3 YALGVDLGGTAIKFGLVSekGEIVERHQTPTpvdegspAIIQKIVEGIQRLGMKDlp----iEGIGIGVPGLvevDKGTV 78  Candidatus Carboba...
CDD85617    5 LYVGIDVGGTSVKIGVMTkeGDVVAKAGVPTppl-vdeAGYTAVTDGVKSVLEGAdvdasllKGIGLAVPCPv-pADGNI 82  Collinsella sp. CA...
Feature 1                                     #                                               
2QM1_A     87 VGAYNL-NWTTVqPVKEQIEsa-lGIPFALDNDANVAALGERWKGAGennPDVIFITLGTGVGGGIVAAGKLLHGvaGCA 164 Enterococcus faeca...
Q9KCZ4     85 YHAVNI-GWRDF-PLKDKLEee-tKLPVIVDNDANIAALGEMWKGAGdgaKNMLLITLGTGVGGGIVANGNILHGvnGMA 161 Halalkalibacterium...
P54495     83 YETVNL-GWKNY-ALKNHLEte-tGIPAVIENDANIAALGEMWKGAGdgaKDVILVTLGTGVGGGIIANGEIVHGinGAG 159 Bacillus subtilis ...
SIA50684   84 IGAYNL-NWKTLqPIKEKIEka-lGIPFFIDNDANVAALGERWMGAGenqPDVVFMTLGTGVGGGIVAEGKLLHGvaGAA 161 Mycobacteroides ab...
TDL91567   85 DVAVNL-GWNNF-PLKDLLEmg-tSLPVIVDNDANAAAIGEMWKGAGqgsKDLLCITLGTGVGGGIISNGQIVHGinGAG 161 Vibrio vulnificus
PWU03044   85 EVAVNL-GWENF-PLQHILEle-tGLPVVVDNDANIAAIGEMWKGAGkgaKNLICVTLGTGVGGGIIVNGEVVHGvnGAA 161 Bacteroidetes bact...
TGV30068   84 MQAVNL-HWTKPvLLKQKLEal-tGRPVEVDNDANAAALGEMWQGAGqgaQDLVLITIGTGVGGGVILNGNVIHGmnGVG 161 Mesorhizobium sp. ...
GBU10962   84 PEAVNLgGFGGF-NVNDTLSvl-lGIPVITDNDANVAAIGEMWLGGGggaDNIAFYTLGTGVGGGLITNGQIISGfsGAG 161 Erysipelotrichacea...
PSL08988   93 EVCVNL-FWKDRyPARELSEll-qGVRVEIGNDANVAALGEAWKGGGegaQDAVMLTLGTGVGGGVILGGQIVSGrhGLG 170 Fusobacterium navi...
AFM40074   84 FEVVNL-GWHQV-PLKEELEri-wDVPVLLENDANAAALGEMWTGAGkgaSHIICLTIGTGIGGGVIINGDIYHGanGSA 160 Desulfosporosinus ...
PTQ57440   79 RLAPNL-NWRAF-PLLTALQda-yPARWVIENDANAALLGERWVGALqgvKHALMLTLGTGVGGAVLAEGRLVRGagGVA 155 Candidatus Carboba...
CDD85617   83 SVIANL-SLNLL-GVHDALQasfpGVYVGFLNDANAAAMGELWRGAGagyNSLVFVTLGTGIGAGVVCDGKVLAGanGAA 160 Collinsella sp. CA...
Feature 1                                                                                     
2QM1_A    165 GEVGHVTVdp----ngFDCTCGKRGCLETvSSATGVVRVARHLseefagdselkqaiddgqdvssKDVFEFAEKGDHFAL 240 Enterococcus faeca...
Q9KCZ4    162 GEIGHITVipe---ggAPCNCGKTGCLETvASATGIARIATEGvtehkesqlal-dydkhgvltaKDVFSAADASDAFAL 237 Halalkalibacterium...
P54495    160 GEIGHICSipe---ggAPCNCGKTGCIETiASATGIVRIAKEKianakkttr----lkateqlsaRDVFEAAGENDEIAL 232 Bacillus subtilis ...
SIA50684  162 GELGHITVdfd---qpIACTCGKKGCLETvASATGIVNLTRRYadeyegdaalkrliddgeevtaKTVFDLAKEGDDLAL 238 Mycobacteroides ab...
TDL91567  162 GEIGHITSlve---dgAPCNCGKTGCIETiASATGIVRLAIEElsftetpsrlrdfynehqilssELVFEVANEGDELAN 238 Vibrio vulnificus
PWU03044  162 GEIGHITSvpk---ggSPCNCGKSGCLETvASATGIVRLALKElsstdnisrlrdyykkqqtitaKLVFDTSNEGDVLAQ 238 Bacteroidetes bact...
TGV30068  162 GEIGHITMapt---ggAPCNCGKTGCLETfTSATAIIREGHLAatngtsphlar-ilaetgkigaKDVFDAAVAGDAASL 237 Mesorhizobium sp. ...
GBU10962  162 GEIGHMPIvtpddplyIKCNCKATGCLETvCSATGIVRIGMYYlennnghkt----clhrddltaKTIFDAAKKDDILAL 237 Erysipelotrichacea...
PSL08988  171 GEIGHIHVrde---eaEACNCGGHGCLEQiASATGIVREAKRKlaesekasam---ralgeklsaKDVCDLGRAGDALAD 244 Fusobacterium navi...
AFM40074  161 GEIGHITVkeq---ggRPCNCGKKGCLETeASATAIVLKTLEQvkgasgllkee-yakqgnsitaKSVVELAKLGDPTCQ 236 Desulfosporosinus ...
PTQ57440  156 GEIGHIPVnk----sgVRCGCGRIGCLETeASATALVRHTKEAlksgkasaleq-ilaqngeltpMDISVAAEAGDVLAR 230 Candidatus Carboba...
CDD85617  161 GELGHVIVnpa---etRQCGCGRHGCLEQyASATGIVNSYRLEcekrgcepa-----elsgpsdsRSVFEALVAGDEAAR 232 Collinsella sp. CA...
Feature 1                                                                                    
2QM1_A    241 XVVDRVCFYLGLATGNLGNTLNPDSVVIGGGVSaAGEFLRSRVEKYFQEFTFPqvr-nsTKIKLAELGNEAGVIGAASL 318 Enterococcus faecal...
Q9KCZ4    238 SVVDHIAYYLGFAIANLANALNPEKIVIGGGVSkAGDTLLKPIKQHFEAYALPrva-dgAEFRIATLGNDAGVIGGGWL 315 Halalkalibacterium ...
P54495    233 EVVDYVAKHLGLVLGNLASSLNPSKIVLGGGVSrAGELLRSKVEKTFRKCAFPraa-qaADISIAALGNDAGVIGGAWI 310 Bacillus subtilis s...
SIA50684  239 IVYRNFSRYLGIACANIGSILNPSTIVIGGGVSaAGEFLLQGVQKVYDENTFPqvr-ttTKLALATLGNDAGVIGAASL 316 Mycobacteroides abs...
TDL91567  239 RVIGKVTLYLGLALAHLANGLNPEKIIIGGGVSkAGDALLVPLKEQFARFAFPrvl-qgVELANATLGNDAGIMGGAWL 316 Vibrio vulnificus
PWU03044  239 SVIQQAAYHLGFALANLANGLNPEKIVIGGGISkAGNTLLEPLKEEFARFSFPrva-qgVEIVTATLGNNAGVIGGAWL 316 Bacteroidetes bacte...
TGV30068  238 AIADQVALYLGLALSHLAIVLNPVKFVIGGGVAaAGDFLFSRIRDSFTRFVPFtyvvesTQILPATLGNDAGVYGAGWL 316 Mesorhizobium sp. M...
GBU10962  238 KIVDRFAQYLGKSLELLSVTINPEVFVIGGGVSnAGEILITAVEKYYGTNIFPatt-knVSIVSARLGNDAGVIGAAKH 315 Erysipelotrichaceae...
PSL08988  245 EVIETVARYLGLAISHLCLIVDPEIFIIGGGVSrAGSYLLDKIKKYYDMYTAIss--nrGRVVLAELGNDAGIYGAVRL 321 Fusobacterium navif...
AFM40074  237 TIIADAGTVLGKALANMCYLLNPELIVIGGGISyAGEILFKPLTESFRNFALPrvr-enTSIVQAKLGNQAGIVGAASL 314 Desulfosporosinus a...
PTQ57440  231 DMFVYVADWLAFALGGLVNTLNPEKVLIGGGLAyAGELLFAPLREAFPRYTLDtal-kdVTLERAQLGNDAGMIGAAWL 308 Candidatus Carbobac...
CDD85617  233 AAVDTMAGALGFELANAACSFDPEVFVLGGGVSaGAEHYLDRVTEVFKKMTLScc--adTPITVASLGNDAGMLGAAYY 309 Collinsella sp. CAG...

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