2H80


Conserved Protein Domain Family
SAM_DLC2
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cd09592: SAM_DLC2 
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SAM domain of STARD13-like subfamily
SAM (sterile alpha motif) domain of DLC2 (Deleted in liver cancer) protein is a lipid-binding and putative protein-protein interaction domain located at the N-terminus of the protein. Members of this subfamily do not form dimers/oligomers through their SAM domains. They participate in lipid transfer. Human Dlc2 gene is known as a tumor suppressor gene. It was found underexpressed in hepatocellular carcinoma.
Links
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Statistics
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PSSM-Id: 188991
Aligned: 4 rows
Threshold Bit Score: 140.548
Created: 30-Apr-2010
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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lipid binding
Conserved site includes 3 residues -Click on image for an interactive view with Cn3D
Feature 1:lipid binding site [chemical binding site]
Evidence:
  • Comment:Highlighted residues are likely involved in membrane binding (based on CD and NMR spectroscopic analysis).
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                    #  # #                                            
2H80_A      18 EIEAKEACDWLRAAGFPQYAQLYEDSQFPINIVAVKNDHDFLEKDLVEPLCRRLNTLNKCASMK 81   human
AAI57468    42 ELEAKEACDWLRAAGFPQYSQLYEDSKFPIDIASVKRDHDFLDRDHVEPLCRRLKTLNKCASMK 105  African clawed frog
CAG00423     1 EIEAKEACDWLKAAGFPQYAQLYEDSQFPVDISSVKRDHDFLERDLVEPLCRRLNTLNKCASMK 64   spotted green pufferfish
XP_417104   57 EIEAKEACDWLRAAGFPQYAQLCEDSQFPIDIAAVKKDHDFLDKDLVEPLCRRLNTLNKCASMK 120  chicken

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