2L0A,3HAJ,3IQL,2D8H,2KBT,1OEB,2DLM,2EPD,2DM1,4GBQ


Conserved Protein Domain Family
SH3

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smart00326: SH3 
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Src homology 3 domains
Src homology 3 (SH3) domains bind to target proteins through sequences containing proline and hydrophobic amino acids. Pro-containing polypeptides may bind to SH3 domains in 2 different binding orientations.
Statistics
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PSSM-Id: 214620
Aligned: 297 rows
Threshold Bit Score: 34.0509
Created: 13-Jul-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2L0A_A      16 EARKVRAIYDFEA----AEDNELTFKAGEIITVLDDs-DPNWWKGETHq---G-IGLFPSNFVT 70   human
Q19253     528 VLGEAIAQFAFDG----AQDGTIRMEANEKLWLIEKdeGDGWTRVRKEn--nSaDGFVPSSYLK 585  Caenorhabditis elegans
P97531     487 PIGQCVAIYHFEG----SSEGTVSMSEGEDLSLMEEdkGDGWTRVRRKq---GgEGYVPTSYLR 543  Norway rat
Q16176       8 PGTQCITKCEHTR----PKPGELAFRKGDVVTILEAceNKSWYRVKHHt--sGqEGLLAAGALR 65   human
AAB33461  1052 PKKLVPGKYTVVMddekGGPDTLAMRSGDMVEVVEEgaEGLWYVRDLTs---SkEGWVPASSLS 1112 Mus sp.
O77291     915 RQGPVQAICAYKQ------QGQLQIEKGETVTLLDNsgRVKWRVRTAK----GqEGPIPGACLL 968  fruit fly
NP_492105   32 PYTPGQLTKNFTA----TVADEISVTRGTTVKAIYR--DDQWIYVEVSd---GrKGFVPQTYCK 86   nematode
NP_499838  548 TAVTVTALFEFAK----SSAETMSIEQGEILLVLEHdhGDGWTRTKNCrkhnEeSGFVPTSYLQ 607  nematode
NP_596017  516 SKVDGVVLYDFTG----EHEGVITASEGQEFTLLEPddGSGWVRVKID----GtDGLIPASYVK 571  Schizosaccharomyces pombe 972h-
EAW87916   634 AIGTCKALYTFEG----QNEGTISVVEGETLYVIEEdkGDGWTRIRRNe---DeEGYVPTSYVE 690  human
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