2HTF,2DUN


Conserved Protein Domain Family
BRCT_polymerase_mu
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cd18442: BRCT_polymerase_mu 
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BRCT domain of DNA-directed DNA/RNA polymerase mu (polymerase mu) and similar proteins
Polymerase Mu (EC 2.7.7.7), also termed Pol mu, or terminal transferase, is a Gap-filling polymerase involved in repair of DNA double-strand breaks by non-homologous end joining (NHEJ). It participates in immunoglobulin (Ig) light chain gene rearrangement in V(D)J recombination. Polymerase Mu contains a BRCT domain.
Links
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Statistics
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PSSM-Id: 349395
Aligned: 6 rows
Threshold Bit Score: 179.27
Created: 21-Jul-2017
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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BRCT sequence
Conserved site includes 2 residues -Click on image for an interactive view with Cn3D
Feature 1: BRCT sequence motif, 2 residue positions
Conserved feature residue pattern:W [CS]Click to see conserved feature residue pattern help
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                        
2HTF_A         7 RFPGVAIYLVEPRMGrSRRAFLTGLARSKGFRVLDACSSeATHVVMEETSAEEAVSWQERRmaaap-----------pgc 75  human
2DUN_A        10 RFPGVAIYLVEPRMGrSRRAFLTGLARSKGFRVLDACSSeATHVVMEETSAEEAVSWQERRmaaap-----------pgc 78  human
AAI18907      61 LFPDVCLFLVERRMGsARRKFLTGLAQKKGFCVTPQFSDqVTHVVSEQNSCSEVLLWIERQsgqkvq--------pggae 132 western clawed ...
Q9NP87        26 RFPGVAIYLVEPRMGrSRRAFLTGLARSKGFRVLDACSSeATHVVMEETSAEEAVSWQERRmaaap-----------pgc 94  human
NP_956542     21 KYPQVCIFILERKMGaSRRAFLTRLGRSKGFLIEDSYSSsVTHVVSENSSAAEVQAWLEKHtrtsssdhllekhthapss 100 zebrafish
XP_005279332  24 RFPAVVLCLVEKRMGaSRRAFLTQLARAKGFRVDRAYSAaVTHVVSEQNSGDEVARWLEQQqeec------------gag 91 

Feature 1                 #   #               
2HTF_A        76 tPPALLDISWLTESLGAGQPVPVECRHRL 104 human
2DUN_A        79 tPPALLDISWLTESLGAGQPVPVECRHRL 107 human
AAI18907     133 mTPHILDITWFTESMSLGKPVKVEPRHCL 161 western clawed frog
Q9NP87        95 tPPALLDISWLTESLGAGQPVPVECRHRL 123 human
NP_956542    101 sSVHLLDICWFTESMEAGEPVPVQHTHTL 129 zebrafish
XP_005279332  92 gDPALLDISWFTESMGSGRPVEIESRHRL 120

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