2KBH,2KBK,2E0H,1LQI,1I6F,1NRB,5CY0,1SNB


Conserved Protein Domain Family
Toxin_3

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pfam00537: Toxin_3 
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Scorpion toxin-like domain
This family contains both neurotoxins and plant defensins. The mustard trypsin inhibitor, MTI-2, is plant defensin. It is a potent inhibitor of trypsin with no activity towards chymotrypsin. MTI-2 is toxic for Lepidopteran insects, but has low activity against aphids. Brazzein is plant defensin-like protein. It is pH-stable, heat-stable and intensely sweet protein. The scorpion toxin (a neurotoxin) binds to sodium channels and inhibits the activation mechanisms of the channels, thereby blocking neuronal transmission. Scorpion toxins bind to sodium channels and inhibit the activation mechanisms of the channels, thereby blocking neuronal transmission
Statistics
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PSSM-Id: 395428
Aligned: 33 rows
Threshold Bit Score: 39.6046
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2KBH_A  2 KDGYIADDRNCPY---FCGR---NAYCDGECKKN-RAESGYCQWA--SKYGNACWCYKLPDDA 55  Chinese scorpion
O22866 28 QGSKCLKEYGGNVgfsYCAPrifPSFCYRNCRKNkGAKGGRCRSGgaGAGSMICLCDYCSDKP 90  thale cress
Q9Y1U3 21 ADGYIRGSDGCKV---SCLWg--NDFCDKVCKKS-GGSYGYC-WT----WGLACWCEGLPDNE 72  Chinese scorpion
P24336 21 ADGYIRKKDGCKV---SCIIg--NEGCRKECVAH-GGSFGYC-WT----WGLACWCENLPDAV 72  Hottentotta judaicus
Q95WX6 21 ADGYIRGSNGCKV---SCLWg--NEGCNKECKAF-GAYYGYC-WT----WGLACWCQGLPDDK 72  Chinese scorpion
P58296  2 RDGYPVDEKGCKL---SCLIn--DKWCNSACHSR-GGKYGYCYTG-----GLACYCEAVPDNV 53  Mexican scorpion
Q8RYE7 29 HDSECLKEYGGDVgfgFCAPkifPTICYRNCQKDkGANGGKCLWG--EGGKVKCLCDFCSNES 89  thale cress
P26780 30 QDSECLKEYGGDVgfpFCAPrifPTICYTRCRENkGAKGGRCIWG--EGTNVKCLCDYCNDSP 90  white mustard
Q42330 28 YDRKCLKEYGGDVgfsYCAPrifPTFCDQNCRKNkGAKGGVCRWEenNAIGVKCLCNFCSEEP 90  thale cress
1NRB_A  2 KDGYPVDSGNCKY---ECLK---DDYCNDLCLER-KADKGYCYWG-----KVSCYCYGLPDNS 52  bark scorpion
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