2D89


Conserved Protein Domain Family
CH_EHBP1
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cd21254: CH_EHBP1 
calponin homology (CH) domain found in EH domain-binding protein 1 and similar proteins
EHBP1 is a regulator of endocytic recycling and may play a role in actin reorganization by linking clathrin-mediated endocytosis to the actin cytoskeleton. It may act as an effector of small GTPases, including RAB-10 (Rab10), and play a role in vesicle trafficking. EHBP1 is associated with aggressive prostate cancer and insulin-stimulated trafficking and cell migration. Members of this subfamily contain a single copy of the CH domain. CH domains are actin filament (F-actin) binding motifs.
Links
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Statistics
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PSSM-Id: 409103
Aligned: 12 rows
Threshold Bit Score: 230.124
Created: 8-Oct-2019
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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putative actin
Conserved site includes 25 residues -Click on image for an interactive view with Cn3D
Feature 1:putative actin binding site [polypeptide binding site]
Evidence:
  • Comment:Based on the structure evidence that Homo sapiens filamin-A binds F-actin.
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1          #   #                                                 # ##  ## #       ########
2D89_A          9 NASQSLLVWCKEVTKNYRGVKITNFTTSWRNGLSFCAILHHFRPDLIDYKSLNPQDIKENNKKAYDGFASIGISRLLEPS 88   human
Q8NDI1        444 NASQSLLVWCKEVTKNYRGVKITNFTTSWRNGLSFCAILHHFRPDLIDYKSLNPQDIKENNKKAYDGFASIGISRLLEPS 523  human
KFO07255       15 NASQSLLVWCKEVTKNYRGVKITNFTTSWRNGLSFCAILHHFRPDLIDYKSLNPQDIKENNKKAYDGFASLGISRLLEPS 94   East African ...
TWW78407       14 NASQSLLAWCREVTKNYRGVKITNFTTSWRNGLAFCALLHHFRPDVIDYKSLNPQDIKENNKKAYDGFASLGISRLLEPS 93   sansaifugu
XP_014340279  446 NSSQSLLAWCKEVTKNYRGVKITNFTTSWRNGLAFCAILHHFRPDRIDYKSLNPQDIKENNKKAYDGFASLGISRLLEPS 525  coelacanth
XP_007890543  366 NASQSLLAWCKEVTKNYRGVKITNFTTSWRNGLAFCAILHHFRTDLIDYKSLNPQDIKENNKKAYECFASLGISRLLEPA 445  elephant shark
OCA33437       14 NASQSLLAWCKEVTKSYRGVKITNFTTSWRNGLAFCAILHHFRPDLIDYKSLNPQDIKENNKKAYDGFASIGISRLLEPS 93   tropical claw...
XP_002610670  381 SATQDLLEWCKEATKGYRGVKVTNFTTSWRNGLAFCAILHHFQPNMIDFSSLSPHDIKGNNKKAYEGFAEVGIPKLLEPS 460  Florida lancelet
ELU13550      306 TPTTDLLAWCKAVTKGYRGVKVTNMTTSWRNGLAFCALIHHFRPDLIDFDSLSPHDIKGNNKLAFDLADHLGIARVLEPS 385  Capitella teleta
XP_006820247  430 TPAQELLEWCKEVTKGYRGVRVTNLTTSWRNGLAFCAVVHHYRPDLIDFASLSPHDIKGNNKKAFNSAAKLGVPKLIDPS 509  Saccoglossus ...
XP_013395912  373 SPAMDLITWCQEVTKGHKGVKVTNMTTSWRNGLAFCAVIHYFRPDLIDFDSLSPHDIKGNNKKAFDAAASLGIPKVMEPS 452  Lingula anatina
RUS78965      259 NPFDDLLSWCRQVTAGHRGVKITNLTTSWRNGLAFCAIVHHYRPDLINYEKLNPHDIKMNNKLAFDAASKLGIPKVLEPS 338  eastern emera...

Feature 1         #       # ## ##  ##  #     
2D89_A         89 DMVLLAIPDKLTVMTYLYQIRAHFSSG 115  human
Q8NDI1        524 DMVLLAIPDKLTVMTYLYQIRAHFSGQ 550  human
KFO07255       95 DMVLLAIPDKLTVMTYLYQIRAHFSGQ 121  East African grey crowned-crane
TWW78407       94 DMVLLAIPDKLTVMTYLYQIRAHFSGE 120  sansaifugu
XP_014340279  526 DMVVLNIPDKLTVMTYLYQIRAHFSGE 552  coelacanth
XP_007890543  446 DMVLLAIPDKLSVMTYLYQIRAHFSGE 472  elephant shark
OCA33437       94 DMVLLAIPDKLTVMTYLYQIRAHFSGQ 120  tropical clawed frog
XP_002610670  461 DMVLLAVPDKLTVMTYLYQIRTHFTGQ 487  Florida lancelet
ELU13550      386 DMVLLAVPDKLSVMTYLYQLRAHFTGQ 412  Capitella teleta
XP_006820247  510 SMVLLSVPDKLSVMTYLFQLRTHFLGQ 536  Saccoglossus kowalevskii
XP_013395912  453 DMQLLAVPDKLSVMTYLYQLRAFFTGQ 479  Lingula anatina
RUS78965      339 DMVLLAVPDKLLVMTYLHQLRSYFTGQ 365  eastern emerald elysia

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