2D7L


Conserved Protein Domain Family
HMG-box_WDHD1
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cd21993: HMG-box_WDHD1 
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high mobility group (HMG)-box found in WD repeat and HMG-box DNA-binding protein 1 (WDHD1) and similar proteins
WDHD1, also called acidic nucleoplasmic DNA-binding protein 1 (And-1), acts as a replication initiation factor that brings together the MCM2-7 helicase and the DNA polymerase alpha/primase complex in order to initiate DNA replication.
Links
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Statistics
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PSSM-Id: 438809
Aligned: 26 rows
Threshold Bit Score: 63.4307
Created: 8-Apr-2019
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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putative DNA
Conserved site includes 20 residues -Click on image for an interactive view with Cn3D
Feature 1:putative DNA binding site [nucleic acid binding site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1           ## #####  ##      #            ##  #  ##      #   #  #   #  #
2D7L_A          5 SSGRPKTGFQMWLEENRSNILSDNPDfsdEADIIKEGMIRFRVLStEERKVWANKAKGETASE 67   human
XP_013779027  971 APPKKKTAFQLFFDKNKPSIAEENPEl-eESDLVKEAVLKFKELPsEDKEMWNQKSSLLDTLE 1032 Atlantic horseshoe crab
RMX41580      743 PPSKKVNGFTLWFEENKGGLSEENPEl-tGTDLVKSAMRQWKALDeDEKMEWNNKAREAAEET 804  Pocillopora damicornis
XP_028403077 1016 ASKPKKSAFQCWLENMKPFFQEENPDl-sESEVMKVAMKQWRETPkEEKQVWENTAKGNVSTV 1077 Dendronephthya gigantea
PIK43737      962 ASQKPASAFQLWFEENKSTIAAEHPEvesETEIFKLAIQKWREVDtETKQKWNHIASNQGSKE 1024 Japanese sea cucumber
PVD25434      973 EPMKKPTAFDLWLTESRDNLQESQSDl-sAEEFSRMAVDTFRALSkEDRQVWIQKAKDQTQLN 1034 Pomacea canaliculata
XP_002604532  998 ENKKVVKGFDLWFEQERATLQEENSEe-sDAGLFQLAIRGWRKLDkQEQKDWNEKAKQMSETT 1059 Florida lancelet
XP_002119176 1043 EVPRVISGVQLFLEEHLQSIEEQHPDl-dGIEVRKIGIKQFRALPaEEKQTWNSRAKSSKVTA 1104 vase tunicate
XP_001329787  484 SEKKLISYIDLFIEERGEKIKEKYPDl-sESDLHSKYIKEFQALPvQEKVKYVSRAAILNDKV 545  Trichomonas vaginalis G3
PRD25934      107 NIKVEKFGFDLFLEEKKEEIKASSSSditEKELIKLALKMFKELPkAEKQKYHKSSSSNDVEE 169  Nephila clavipes

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