2PI7,2G59


Conserved Protein Domain Family
R-PTPc-O
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cd14614: R-PTPc-O 
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catalytic domain of receptor-type tyrosine-protein phosphatase O
Receptor-type tyrosine-protein phosphatase O (PTPRO or R-PTP-O), also known as glomerular epithelial protein 1 or protein tyrosine phosphatase U2 (PTP-U2), belongs to the family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. PTPRO is a member of the R3 subfamily of receptor-type phosphotyrosine phosphatases (RPTP), characterized by a unique modular composition consisting of multiple extracellular fibronectin type III (FN3) repeats and a single (most RPTP subtypes have two) cytoplasmic catalytic PTP domain. It is essential for sustaining the structure and function of foot processes by regulating tyrosine phosphorylation of podocyte proteins. It has been identified as a synaptic cell adhesion molecule (CAM) that serves as a potent initiator of synapse formation. It is also a tumor suppressor in several types of cancer, such as hepatocellular carcinoma, lung cancer, and breast cancer.
Links
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Statistics
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PSSM-Id: 350462
Aligned: 7 rows
Threshold Bit Score: 527.149
Created: 29-Sep-2010
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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active sitecatalytic site
Conserved site includes 12 residues -Click on image for an interactive view with Cn3D
Feature 1: active site [active site], 12 residue positions
Conserved feature residue pattern:x x x x C x x x x x R xClick to see conserved feature residue pattern help
Evidence:
  • Structure:2G59: Human PTPRO binds phosphate; contacts at 4A
  • Comment:mostly based on binding of human R-PTP-beta to inhibitors
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                          # #                                                            
2PI7_A         47 DIPHFAADLPmnrcKNRYTNILPYDFSRVRLVSmneeeGSDYINANYIPGYnsPQEYIATQGPLpetrnDFWKMVLQQks 126  chicken
2G59_A         40 DIPHFAADLPlnrcKNRYTNILPYDFSRVRLVSmneeeGADYINANYIPGYnsPQEYIATQGPLpetrnDFWKMVLQQks 119  human
NP_001077283  973 DLSHEAADLPinrpKNRYTNILPYDFSRVKLISlhndeGSDYINANYIPGYnsPREYIATQGPLpdtrnDFWKMVLQQkv 1052 zebrafish
Q16827        951 DIPHFAADLPlnrcKNRYTNILPYDFSRVRLVSmneeeGADYINANYIPGYnsPQEYIATQGPLpetrnDFWKMVLQQks 1030 human
XP_006006115  930 DIPHVAADLPvnrcKNRYTNILPYDFSRVKLVSmhddeGLDYINANYIPGYtsPQEYIATQGPLpetrnDFWKMVLQQns 1009 coelacanth
XP_018107292 1024 DIPHFAANLPsnrgKNRYTNILPYDFSRVKLISldadeGADYINANYIPGYsaVQEYIATQGPLpetrnDFWKMILQQkc 1103 African clawe...
XP_007902372  957 DVSHDTAELPvnrcKNRYTNILPYDFSRVKLVSlhdeeGSDYINANYIPGYnsPHEYIATQGPLaetrrDFWRMVLQQks 1036 elephant shark

Feature 1                                                                                         
2PI7_A        127 QIIVMLTQCNekrRVKCDHYWPFTEDPiaygDITVEMLSEEEHt------------dWVYRNFRISYadEVQDVMHFNYT 194  chicken
2G59_A        120 QIIVMLTQCNekrRVKCDHYWPFTEEPiaygDITVEMISEEEQd------------dWACRHFRINYadEMQDVMHFNYT 187  human
NP_001077283 1053 HIIVMLTQCNerrRVKCDHYWPFSDEPvaygEISVEMLAETDSp------------eWTIRSFRLAYadETQDVLHFNYT 1120 zebrafish
Q16827       1031 QIIVMLTQCNekrRVKCDHYWPFTEEPiaygDITVEMISEEEQd------------dWACRHFRINYadEMQDVMHFNYT 1098 human
XP_006006115 1010 SIIVMLTQCNekrRVKCDHYWPFTEDPvsygDITVEMLSEEEQt------------eWVIREFRVSYadEVQDVLHFNYT 1077 coelacanth
XP_018107292 1104 QVIVMLTQCNekrRIKCDHYWPFTSEPvnygDITVEMVSEEEQs------------dWAQRVFRVSYgdESQCVTHFNFT 1171 African clawe...
XP_007902372 1037 HIIVMLTQCNerrRVKCDHYWPFNKEPvcygDITVEMVFESELpdqsedseqseqpeWIIREFNVSYadAVQRVIHYNYM 1116 elephant shark

Feature 1            ##                                #######                                    
2PI7_A        195 AWPDHGVPtanaAESILQFVQMVRQKsvkskGPMIIHCSAGVGRTGTFIALDWLLQHIrdHEFVDILGLVSDMRSYRMSM 274  chicken
2G59_A        188 AWPDHGVPtanaAESILQFVHMVRQQatkskGPMIIHCSAGVGRTGTFIALDRLLQHIrdHEFVDILGLVSEMRSYRMSM 267  human
NP_001077283 1121 SWPDHGVPtvnaIESILQFVQIVRQQvnrskGPIVVHCSAGVGRTGTFISLDRLMQHIqeHEYVDVLGLVSDMRSHRLSM 1200 zebrafish
Q16827       1099 AWPDHGVPtanaAESILQFVHMVRQQatkskGPMIIHCSAGVGRTGTFIALDRLLQHIrdHEFVDILGLVSEMRSYRMSM 1178 human
XP_006006115 1078 AWPDHGVPttnaAESILQFVQMIRQRrgkrkGPMIIHCSAGVGRTGTYIALDRLLQYIqdHEFVDILGLVAELRSYRTSM 1157 coelacanth
XP_018107292 1172 AWPDHGVPtvnaAESVLHFVHVVRQKalktkGPITVHCSAGVGRTGTFIALDCLMQHIrdHEFVDILGLVSELRSYRMSM 1251 African clawe...
XP_007902372 1117 AWPDHGVPnadtAENILQFVQMIRQQtvkrpGSIIVHCSAGVGRTGTLIALDRLMQHIheHEYVDILGLVSEMRMYRTSM 1196 elephant shark

Feature 1          #               
2PI7_A        275 VQTEEQYIFIHQCVQLM 291  chicken
2G59_A        268 VQTEEQYIFIHQCVQLM 284  human
NP_001077283 1201 VQTEEQYVFIHQCVLLM 1217 zebrafish
Q16827       1179 VQTEEQYIFIHQCVQLM 1195 human
XP_006006115 1158 VQTEEQYIFIHRCVQLL 1174 coelacanth
XP_018107292 1252 VQTEEQFVFIHQCVQLM 1268 African clawed frog
XP_007902372 1197 VQTEEQYIFIHRCVQLM 1213 elephant shark

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