1ZQ0,1YD9,1ZR3,1ZR5,2XD7,3IIF,5IIT,6FY5


Conserved Protein Domain Family
Macro_H2A-like

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cd02904: Macro_H2A-like 
Click on image for an interactive view with Cn3D
macrodomain, macroH2A-like family
Macrodomains are found in a variety of proteins with diverse cellular functions, as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Macrodomains can recognize ADP-ribose (ADPr) in both its free and protein-linked forms, in related ligands, such as O-acyl-ADP-ribose (OAADPr), and even in ligands unrelated to ADPr. Members of this family are similar to macroH2A, a variant of the major-type core histone H2A, which contains an N-terminal H2A domain and a C-terminal nonhistone macrodomain. Histone macroH2A is enriched on the inactive X chromosome of mammalian female cells. It does not bind poly ADP-ribose, but does bind the monomeric SirT1 metabolite O-acetyl-ADP-ribose (OAADPR) with high affinity through its macrodomain. This family also includes the ADP-ribose binding macrodomain of the macroH2A variant, macroH2A1.1. The macroH2A1.1 isoform inhibits PARP1-dependent DNA-damage induced chromatin dynamics. The putative ADP-ribose binding pocket of the human macroH2A2 macrodomain exhibits marked structural differences compared with the macroH2A1.1 variant.
Statistics
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PSSM-Id: 394875
Aligned: 26 rows
Threshold Bit Score: 290.755
Created: 20-Sep-2005
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
 
ADP-ribose
Conserved site includes 23 residues -Click on image for an interactive view with Cn3D
Feature 1:ADP-ribose binding site [chemical binding site]
Evidence:
  • Structure:3IIF: human Histone macroH2A1.1 binds ADP-ribose, contacts at 4A

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                ##           ###   # ####  #                            
1ZQ0_A        20 TPADGFTVLSTKSLFLGQKLQVVQADiaSIDSDAVVHPTNTDFYIGGEVGNTLEKKGGKEFVEAVLELRkKNGPLevAGA 99  human
3IIF_A        20 TPADGFTVLSTKSLFLGQKLQVVQADiaSIDSDAVVHPTNTDFYIGGEVGNTLEKKGGKEFVEAVLELRkKNGPLevAGA 99  human
XP_781668    186 KTISGKSILGEKKLFLGQKLTVVKADltEITADALVHPTNSTYAMAGEVGSALEKVGGRAFVEEVAKLR-AAQSLdiSGA 264 purple urchin
XP_002111582 162 FKNSEVTILSEKQLFLGQKLIVTKGDitKISTDGIVHPTSSNFSHAGMIGGALSSAGGKQYMDGVAKVEqETGSLpvAGV 241 Trichoplax adha...
XP_002596090 192 AMATGITILSEKKLFLGQKLTVIQGNivNLPADAVIHPTNDSFYLGGEVGSALQKAGGKEFEGEVKKLLeANGSLdtTGA 271 Florida lancelet
XP_002737268 197 KGIGGVTILSEKKLFLGQKMTVVQGDiaTLVADAIVHPTNSSFYMGGEVGSQLEKVGGKDFQQEVQDLYkNHGALdtAGA 276 Saccoglossus ko...
XP_003389250 173 GSGKGYTTLSEKILSGGQKLTVVQGDisTIACDAVIHPTNGSLSLSGQCGSALSNAGGPAFRTQVNQTS-SKGSIgvGDA 251 Amphimedon quee...
ELT93761     180 ADPGAFTILSEKKLFLGQKLTVLQGDivNVVADAIIHPTNASLYMGGEVGQTIERTGGKEFQQEVKDLLsTNGDLdtAGA 259 Capitella teleta
XP_002154422 177 KSDPVFAVLSEKNLYLGQKLTVVQGNiaEMKCDALIHPTNATFNTTGEVGSALLKVGGEELKKAISALHsSHGDLamSSA 256 Hydra vulgaris
XP_013091556 176 DGSGGFLTLSEKKLFLGQKLTVMQGDivKMVADAIVHPTNSTYHLGGEVGQAILKAGGKEFQQEIDSLLkNQGSIatAEA 255 Biomphalaria gl...
Feature 1                         #                                   #######   #                
1ZQ0_A       100 AVSAGHGLPAKFVIHCNSPVWgad-kcEELLEKTVKNCLALADDKKLKSIAFPSIGSGRNGFPKQTAAQLILKAISSYFV 178 human
3IIF_A       100 AVSAGHGLPAKFVIHCNSPVWgad-kcEELLEKTVKNCLALADDKKLKSIAFPSIGSGRNGFPKQTAAQLILKAISSYFV 178 human
XP_781668    265 AICPAHNLPAKYVIHVNSPSWgga-naVSNLEKCIKNCLALADEKNITSIAIPSVSSGRAGFPKQIAAETILRTISHYFV 343 purple urchin
XP_002111582 242 TGSPAANLSAQEVIHVHSPSWgst-dcQGNLEKAVRNILDYADKKGMKSVAIPSIGSGSNNFPKLTAAQIILRSIAKYFV 320 Trichoplax adha...
XP_002596090 272 AICPGHNFPAKYVIHCNGPSWntd-kcQDNMEKTVKNCLALADEKDLTSVAFPSIGSGRAGWPKQTAAQLILKAISNYFS 350 Florida lancelet
XP_002737268 277 AICPGHNFPAKYVVHVNSPGWgna-ssIPNLEKAVKNILSLADEKNLTSVAIPSIGSGRGGFPKQAAAQTIVRAIQNYFV 355 Saccoglossus ko...
XP_003389250 252 VISGAGSLPCAHVIHVHSPSWgsd-daLSKLEKSVQSCLNVAEKHKLSSVGFPSIASGSNSFPKQTSAQSILRTIKDYYT 330 Amphimedon quee...
ELT93761     260 LLCRGYNFPAKFVIHCNGPRWkdv-dsQQLLEQTVKNCLSLADEKQLKSLAFPSIGSGRAGFPKQTAAQIILRAINNYFV 338 Capitella teleta
XP_002154422 257 LLGDSVNLKAKHIIHVHSPTYvsggssEEDLENVVKNALTLADEKNVAVIAFPSIGSGINSFPKQLAAQTILKAISNYFV 336 Hydra vulgaris
XP_013091556 256 AICPGHKFSAKFVIHVNSPTWgen-nsQQNLDKAVKNVLKLADDKQLKSLAIPSISSGNAGFPKQTAAQIILASIRDYFS 334 Biomphalaria gl...
Feature 1                      ##  #          
1ZQ0_A       179 stmsSSIKTVYFVLFDSESIGIYVQEMAK 207 human
3IIF_A       179 stmsSSIKTVYFVLFDSESIGIYVQEMAK 207 human
XP_781668    344 svmaSSLKQIYFVLFDQESVEVYVTELNR 372 purple urchin
XP_002111582 321 gvmsSSLKEVYFVLWDEESINIYTSELNK 349 Trichoplax adhaerens
XP_002596090 351 sqmtSSIKQVYFVLFDMESIGVYTSELAK 379 Florida lancelet
XP_002737268 356 svmaSSLKQIYFVLYDMESIGIYTSEMAK 384 Saccoglossus kowalevskii
XP_003389250 331 gt-sGSVKQVFFVLYDMESIGIYTSELAR 358 Amphimedon queenslandica
ELT93761     339 tvvsSSLKQIYFVLYDMESIGVYTSELAK 367 Capitella teleta
XP_002154422 337 tvvsSSLKQIYFVLYDMESIGVYTTELAK 365 Hydra vulgaris
XP_013091556 335 naktTSLKQIYFVLFDAESVNVYTTELAR 363 Biomphalaria glabrata

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