2RRA,2KXN,2RRB,2CQC


Conserved Protein Domain Family
RRM_TRA2B

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cd12641: RRM_TRA2B 
Click on image for an interactive view with Cn3D
RNA recognition motif (RRM) found in Transformer-2 protein homolog beta (TRA-2 beta) and similar proteins
This subgroup corresponds to the RRM of TRA2-beta or TRA-2-beta, also termed splicing factor, arginine/serine-rich 10 (SFRS10), or transformer-2 protein homolog B, a mammalian homolog of Drosophila transformer-2 (Tra2). TRA2-beta is a serine/arginine-rich (SR) protein that controls the pre-mRNA alternative splicing of the calcitonin/calcitonin gene-related peptide (CGRP), the survival motor neuron 1 (SMN1) protein and the tau protein. It contains a well conserved RNA recognition motif (RRM), also termed RBD (RNA binding domain) or RNP (ribonucleoprotein domain), flanked by the N- and C-terminal arginine/serine (RS)-rich regions. TRA2-beta specifically binds to two types of RNA sequences, the CAA and (GAA)2 sequences, through the RRMs in different RNA binding modes.
Statistics
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PSSM-Id: 410046
Aligned: 8 rows
Threshold Bit Score: 158.246
Created: 21-Sep-2011
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
 
RNA binding
Conserved site includes 19 residues -Click on image for an interactive view with Cn3D
Feature 1:RNA binding site [nucleic acid binding site]
Evidence:
  • Structure:2RRA; Human Tra2 beta RRM protein binds RNA (GAAGAA), contacts at 4A.
  • Structure:2KXN; Human Tra2beta1 RRM binds RNA (AAGAAC), contacts at 4A.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1        #       #   ##                       # #        # # # #                     ####
2RRA_A         9 RANPDPNCCLGVFGLSLYTTERDLREVFSKYGPIaDVSIVYDQQsrrsRGFAFVYFENvDDAKEAKERANGMElDGRRIR 88  human
2KXN_B        40 RANPDPNCCLGVFGLSLYTTERDLREVFSKYGPIaDVSIVYDQQsrrsRGFAFVYFENvDDAKEAKERANGMElDGRRIR 119 human
NP_990009    111 RANPDPNCCLGVFGLSLYTTERDLREVFSKYGPIaDVSIVYDQQsrrsRGFAFVYFENvEDAKEAKERANGMElDGRRIR 190 chicken
2RRB_A         6 RANPDPNCCLGVFGLSLYTTERDLREVFSKYGPIaDVSIVYDQQsrrsRGFAFVYFENvDDAKEAKERANGMElDGRRIR 85  human
2CQC_A         9 RANPDPNCCLGVFGLSLYTTERDLREVFSKYGPIaDVSIVYDQQsrrsRGFAFVYFENvDDAKEAKERANGMElDGRRIR 88  human
OCT61404     124 KANPDPNCCLGVFGLSLYTTERDLREVFSKYGPLsDVSIVYDQQsrrsRGFSFVYFENvDDAKEAKERANGMElDGRRLR 203 African clawed ...
XP_005994333 193 RANPDPNCCLGVFGLSLYTTERDLRDVFSKYGPLaDVSIVYDQQsrrsRGFAFVYFENvEDSKEAKERANGMElDGRRIR 272 coelacanth
NP_957491    116 RANPDPNCCLGVFGLSLYTTERDLREVFSKYGPLsDVCIVYDQQsrrsRGFALVYFENrEDSKEAKERANGMElDGRRIR 195 zebrafish
Feature 1          #####
2RRA_A        89 VDFSITK 95  human
2KXN_B       120 VDFSITK 126 human
NP_990009    191 VDFSITK 197 chicken
2RRB_A        86 VDFSITK 92  human
2CQC_A        89 VSGPSSG 95  human
OCT61404     204 VDFSITK 210 African clawed frog
XP_005994333 273 VDYSITK 279 coelacanth
NP_957491    196 VDYSITK 202 zebrafish

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