1PMP,3NR3,2WUT,1YIV,1PMP,4D6A


Conserved Protein Domain Family
FABP8

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cd19469: FABP8 
fatty acid binding protein 8
FABP8 (also known as peripheral myelin protein 2, PMP2, myelin fatty acid binding protein, M-FABP, myelin P2 protein, MP2) is a fatty acid-binding structural component of the myelin sheath in the peripheral nervous system and may play a role in lipid transport and homeostasis in myelin. It may bind cholesterol which is present in myelin at high concentrations. In addition to binding momomeric ligands, P2 is able to bind membrane surfaces, and to stack lipid bilayers together. This subgroup belongs to the intracellular fatty-acid binding protein (FABP) family, members of which are small proteins that bind hydrophobic ligands in a non-covalent, reversible manner, and have been implicated in intracellular uptake, transport and storage of hydrophobic ligands, regulation of lipid metabolism and sequestration of excess toxic fatty acids, as well as in signaling, gene expression, inflammation, cell growth and proliferation, and cancer development.
Statistics
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PSSM-Id: 381244
Aligned: 7 rows
Threshold Bit Score: 237.259
Created: 13-May-2008
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
ligand binding
Conserved site includes 40 residues -Click on image for an interactive view with Cn3D
Feature 1:ligand binding cavity [chemical binding site]
Evidence:
  • Comment:ligand is bound within the beta-barrel in a central internal water-filled cavity lined with polar and hydrophobic amino acids
  • Comment:based on FABP3 and other cytosolic fatty-acid binding protein family members with structure
  • Structure:1PMP; Bos taurus P2 myelin protein with bound oleic acid, contacts 4A
  • Citation:PMID 7683727

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1          #           #  ##  # #   ## ##  # # # #      # # # # ## # # #       ##### #   
1PMP_A         2 NKFLGTWKLVSSENFDEYMKALGVGLATRKLGNLAKPRVIISKKGDIITIRTESPFKNTEISFKLGQEFEETTADNRKTK 81  cow
3NR3_A        24 NKFLGTWKLVSSENFDDYMKALGVGLATRKLGNLAKPTVIISKKGDIITIRTESTFKNTEISFKLGQEFEETTADNRKTK 103 human
2WUT_A         4 NKFLGTWKLVSSENFDDYMKALGVGLATRKLGNLAKPTVIISKKGDIITIRTESTFKNTEISFKLGQEFEETTADNRKTK 83  human
1YIV_A         2 NKFLGTWKLVSSENFDDYMKALGVGLATRKLGNLAKPTVIISKKGDVITIRTESGFKNTEISFKLGQEFDETTADNRKAK 81  horse
1PMP_C         2 NKFLGTWKLVSSENFDEYMKALGVGLATRKLGNLAKPRVIISKKGDIITIRTESPFKNTEISFKLGQEFEETTADNRKTK 81  cattle
NP_001186405   3 NRFVGTWKLVSSENFDDYMKELGVGLATRKLGGLSKPSVIISMKGDIVTLRTESTFKNTEISFKLGQQFDETTADDRKVK 82  chicken
4D6A_A         4 NKFLGTWKLVSSENFDDYMKALGVGLATRKLGNLAKPTVIISKKGDIITIRTESTFKNTEISFKLGQEFEETTADNRKTK 83  human
Feature 1                 # #          # #      # # ##      #  # #  
1PMP_A        82 STVTLARGSLNQVQKWNGNETTIKRKLVDGKMVVECKMK--DVVCTRIYEK 130 cow
3NR3_A       104 SIVTLQRGSLNQVQRWDGKETTIKRKLVNGKMVAECKMK--GVVCTRIYEK 152 human
2WUT_A        84 SIVTLQRGSLNQVQRWDGKETTIKRKLVNGKMVAECKMK--GVVCTRIYEK 132 human
1YIV_A        82 STVTLAAGALNQVQKWNGNETTIKRKLVDGKMVVECKMA--SVVCTRIYEK 130 horse
1PMP_C        82 STVTLARGSLNQVQKWNGNETTIKRKLVDGKMVVECKMK--DVVCTRIYEK 130 cattle
NP_001186405  83 SVVTLEKGSLVQVQKWNGKETTIKRRLVDGKMVVECAMK--GVVCTRVYER 131 chicken
4D6A_A        84 SIVTLQRGSLNQVQRWDGKETTIKRKLVNGKMVAEXCKMkgVVXCTRIYEK 134 human

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