2A08,1OOT


Conserved Protein Domain Family
SH3_Ysc84p_like
?
cd11842: SH3_Ysc84p_like 
Click on image for an interactive view with Cn3D
Src homology 3 domain of Ysc84p and similar fungal proteins
This family is composed of the Saccharomyces cerevisiae proteins, Ysc84p (also called LAS17-binding protein 4, Lsb4p) and Lsb3p, and similar fungal proteins. They contain an N-terminal SYLF domain (also called DUF500) and a C-terminal SH3 domain. Ysc84p localizes to actin patches and plays an important in actin polymerization during endocytosis. The N-terminal domain of both Ysc84p and Lsb3p can bind and bundle actin filaments. A study of the yeast SH3 domain interactome predicts that the SH3 domains of Lsb3p and Lsb4p may function as molecular hubs for the assembly of endocytic complexes. SH3 domains are protein interaction domains that bind to proline-rich ligands with moderate affinity and selectivity, preferentially to PxxP motifs. They play versatile and diverse roles in the cell including the regulation of enzymes, changing the subcellular localization of signaling pathway components, and mediating the formation of multiprotein complex assemblies.
Links
?
Statistics
?
PSSM-Id: 212776
Aligned: 10 rows
Threshold Bit Score: 97.109
Created: 6-Jun-2011
Updated: 2-Oct-2020
Structure
?
Program:
Drawing:
Aligned Rows:
Download Cn3D
 
peptide ligand
Conserved site includes 9 residues -Click on image for an interactive view with Cn3D
Feature 1:peptide ligand binding site [polypeptide binding site]
Evidence:
  • Comment:based on the binding of peptide ligands to the SH3 domains of other superfamily members
  • Comment:SH3 domains typically bind proline-rich ligands, preferentially to PxxP motifs.
  • Citation:PMID 7664083
  • Citation:PMID 7735837
  • Comment:flanking hinge and loops (RT and n-Src) confer sequence specificity for ligand residues outside the core binding motif
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Feature 1          # #  #   #                   ##            # ##   
2A08_A      5 TAVALYNFAGEQPGDLAFKKGDVITILKKSdsqNDWWTGRTNGKEGIFPANYVRV 59  baker's yeast
1OOT_A      5 KAVALYSFAGEESGDLPFRKGDVITILKKSdsqNDWWTGRVNGREGIFPANYVEL 59  baker's yeast
Q9URW6    375 QARAMYSFAGEQPGDLSFQKGDIIDIVERSgshDDWWTGRIGYREGIFPANYVKL 429 Schizosaccharomyces pombe 972h-
P43603    404 KAVALYSFAGEESGDLPFRKGDVITILKKSdsqNDWWTGRVNGREGIFPANYVEL 458 Saccharomyces cerevisiae S288c
EEH09562  352 QVVALFTFDADQEGDLGFKKGEIITILKRTdkkEDWWTGRIGDRTGIFPSNYVDA 406 Ajellomyces capsulatus G186AR
CCC67457  379 EAVALYRFTGEQKGDLSFQKGDKITILKRTesqNDWWSGRVNGKEGIFPANYVEL 433 Naumovozyma castellii CBS 4309
EGG03801  294 KAVAVYDFKPTEEGDLGFQKGDMIKIESKId--DDWWTGSIGMRKGIFPRNRLKE 346 Melampsora larici-populina 98AG31
CCA75237  412 RAIVRFDFEAVEVEDLTIRKGDIITILEKSnsmNDWWKGKIGTRVGQFPANFVEV 466 Piriformospora indica
EFN71987  340 YGVALYDFPATHPDDLALEKGDIVQLIKKVn--NDWLEGRIGNRQGIFPFNFIDI 392 Camponotus floridanus
P32793    413 TAVALYNFAGEQPGDLAFKKGDVITILKKSdsqNDWWTGRTNGKEGIFPANYVRV 467 Saccharomyces cerevisiae S288c

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap