1BC2,2M5D


Conserved Protein Domain Family
BcII-like_MBL-B1
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cd16304: BcII-like_MBL-B1 
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Bacillus cereus Beta-lactamase 2 and related metallo-beta-lactamases, subclass B1; MBL-fold metallo-hydrolase domain
Bacillus cereus Beta-lactamase 2, also called BcII. MBLs (class B of the Ambler beta-lactamase classification) have been divided into three subclasses B1, B2 and B3, based on sequence/structural relationships and substrates, with the B1 and B2 MBLs being most closely related to each other. BcII is a chromosome-encoded B1 MBL. B1 enzymes are most active with two zinc ions bound in the active site, and have a broad-spectrum substrate profile.
Links
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Statistics
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PSSM-Id: 293862
Aligned: 14 rows
Threshold Bit Score: 331.171
Created: 15-May-2015
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 12 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:2M5D: Bacillus cereus metallo-beta-lactamase BcII binds the broad spectrum inhibitor R-thiomandelic acid and two zinc ions
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                       #    #                   #                              # ### 
1BC2_A     16 ISISQLNKNVWVHTELGSFnGEAVPSNGLVLNTskGLVLVDSSW----DDKLTKELIEMVEKKFqKRVTDVIITHAHADR 91  Bacillus cereus
2M5D_A     16 ISISQLNKNVWVHTELGSFnGEAVPSNGLVLNTskGLVLVDSSW----DDKLTKELIEMVEKKFqKRVTDVIITHAHADR 91  Bacillus cereus
KKB71816   43 VVLTKLNNNVWAHTSFNDWnGTTYDHNGLVISTskGLVLIDTAWg---DDQKTEELLRLSEKHLkKKVVLALITHAHDDS 119 Bacillus sp. TH008
EMY68219   69 LEWIKIKESVWIHRSFGEFgGQIYSANGLVVLTnkGVVVVDTPW----TESQTEELFSEIQAKFqKEILYVIVTHAHDDR 144 Leptospira vanthie...
EQA35364   22 IRVSPLTENFYVHTSYHIIdDLPFPSNGLIIATksGAILIDTAW----GNEQTVQILLWIKENLkMPVRLAILTHFHDDR 97  Leptospira inadai ...
EMJ99996   35 LLVSQIGKNIYVHTSYKLLkDGYFPSNGLLIETgeGVVLVDTAW----GEEQTFELLDWISNNLkKPVIAVIITHFHEDR 110 Leptospira sp. B5-022
AKD05560    8 LEVTKISSKVWIHTSYKTYhGTVVPSHGLIVSTkeGAVLIDTGW----GKEPTEELLTWIKTNLkQPVKVCVPTHWHDDK 83  Pontibacter korlensis
AEI50718   25 VEITSLVPNHYVHTTYQLIqNNPFPSNGLIVSTsvGIVLVDTGW----GLEQTEKLLAQIEQKLkQKVVLCIVTHAHEDR 100 Runella slithyform...
CCH02699   31 LRVSRLSDRVFVHTTYGMYqGEPVPSNGLIVRTddGVVLLDTGWdtegNTDNTRQLLRWVADSLrLPVRLCIVTHSHDDK 110 Fibrella aestuarin...
EIT86917   54 LIIKKIRPHVWMHISTGTFnGQRVSANGLIVEHsnKLLLIDSTW----TEQETKDLLDLTKKYLhKEVKEAIITHSHQDK 129 Bacillus macauensi...

Feature 1                                                               #                  #  
1BC2_A     92 IGGIKTLKERGIKAHSTALTAELAKKNgYEEPLGDLQt-VTNLKfgnmKVETFYPGKGHTEDNIVVWLPQYNILVGGCLV 170 Bacillus cereus
2M5D_A     92 IGGIKTLKERGIKAHSTALTAELAKKNgYEEPLGDLQt-VTNLKfgnmKVETFYPGKGHTEDNIVVWLPQYNILVGGCLV 170 Bacillus cereus
KKB71816  120 ISGIRALLNQGIDVRSTRLTAKLAKEYgYPSPNPALDa-RPVMKvgntVIEAFYPGEGHSKDNITVWLPQSQLLFGGCFI 198 Bacillus sp. TH008
EMY68219  145 MAGVSLFQNRNIPIYSTNLTAKLAKERgFGKTNPILDl-QTRLGagnqSVEVFYPGPGHSVDNIVVWLPDTHILFGGCLV 223 Leptospira vanthie...
EQA35364   98 AGGIQELKNRNIPSYANRRTIQKMKSLnLPVPDRLLKd-EMNFRmddlVFKVLYPGHGHTEDNIVVWFPVSKVLFGGCLV 176 Leptospira inadai ...
EMJ99996  111 AGGIDILKKQNIPSYAGKRTISILKEEgESVPEKVLKd-KDLLVfgktKIETFFPGAGHSKDNLVVWLPGSRILFGGCLV 189 Leptospira sp. B5-022
AKD05560   84 LGGMEAVQRQGVPVVTSELTAILAAENsKGTPDVTFAt-DTTFAiggqQLEVYFPGGGHTADNVVVYLPQQKILFGGCLV 162 Pontibacter korlensis
AEI50718  101 IGGVKAFQQRGIKIIGTPLTAQKTVAQgLPAPEGILPq-DTTFRvgdtTIQTYFPGAGHTDDNIVIYFPNSKVLVGGCLI 179 Runella slithyform...
CCH02699  111 VGGIVELQKAGIRVVSTPLTAQKTVKQgYPSPDGILPa-DTTFTignvPIRTYFPGEGHTVDNIVVWLPSERILHGGCFV 189 Fibrella aestuarin...
EIT86917  130 IGGVKTLEKNGVHVYSTKLTAELAKKNnHPQPKYRLQdsVTHFNldgvKVETYYAGQGHTADNIVVYLQKEKLLYGGCLI 209 Bacillus macauensi...

Feature 1              #  #                          #                  
1BC2_A    171 KstsaKDLGNVADAYVNEWSTSIENVLKRYRNINAVVPGHG-EVGDKGLLLHTLDLLK 227 Bacillus cereus
2M5D_A    171 KstsaKDLGNVADAYVNEWSTSIENVLKRYRNINAVVPGHG-EVGDKGLLLHTLDLLK 227 Bacillus cereus
KKB71816  199 KsleaKDLGNLSDANVEQWDDSVQQVIDKYPNVKTVVPGHG-NWGDRSLLFHTLDLIK 255 Bacillus sp. TH008
EMY68219  224 KsldaKDLGNTKDANLEEWENSLKRVLARYPDAEVVVPGHG-DWGKLDLLRHTIRLLV 280 Leptospira vanthielii serovar Holland st...
EQA35364  177 KspqaKSLGNSRDANLVEWAKAIRSLERSFSNAKFVIPGHE-AWGGPEAFRRTLELLS 233 Leptospira inadai serovar Lyme str. 10
EMJ99996  190 KsveaDDIGNTKDADLKEWPKTIRKLEKMFPKISIIVPGHQ-AWGGRESLKRTLELLG 246 Leptospira sp. B5-022
AKD05560  163 KdlqaKNLGNTADADLKSWPLAIQRLQQRYPKAKVVVPSHG-PWGDQSLLSHTLSLLQ 219 Pontibacter korlensis
AEI50718  180 KsyvaMGIGNIADANLKTWKQSVNNVRNKFPNAEFVIPGHE-KWDNLTSFSRTIELVE 236 Runella slithyformis DSM 19594
CCH02699  190 KsvaaFGMGYVGESNLTAWSGSIRNVKKRFGNARIVVPGHE-EWTGPQALDHTLRLLE 246 Fibrella aestuarina BUZ 2
EIT86917  210 KgkefHDLGNIEDANVKEWPTTVKAVKKRYPSIDTLVPGHGaIGKGQGLLQHTLDLLQ 267 Bacillus macauensis ZFHKF-1

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