1PAX,1A26,1UK0,1GS0


Conserved Protein Domain Family
parp_like

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cd01437: parp_like 
Click on image for an interactive view with Cn3D
Poly(ADP-ribose) polymerase (parp) catalytic domain catalyses the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component induced by DNA damage. The carboxyl-terminal region is the most highly conserved region of the protein. Experiments have shown that a carboxyl 40 kDa fragment is still catalytically active. Poly(ADP-ribose)-like polymerases (PARPS 1-3, VPARP, tankyrase) catalyze the addition of up to 100 ADP_ribose units from NAD+. PARPs 1 and 2 are localized in the nucleaus, bind DNA, and are activated by DNA damage. VPARP is part of the vault ribonucleoprotein complex. Tankyrases regulates telomere length through interactions with telomere repeat binding factor 1.
Statistics
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PSSM-Id: 238717
Aligned: 29 rows
Threshold Bit Score: 243.331
Created: 12-Dec-2003
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
parp regulatorynad+ contactInhibitor
Conserved site includes 120 residues -Click on image for an interactive view with Cn3D
Feature 1:parp regulatory domain
Evidence:
  • Citation:PMID 9521710
  • Comment:Contacts infered by comparison to diphtheria toxin

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1      ############################# ##################################                
1PAX         9 KSKLAKPIQDLIKMIFDVESMKKAMVEFE-IDLQKMPLGKLSKRQIQSAYSILNEVQQAVSDGGs--------------- 72   chicken
1A26         9 KSKLAKPIQDLIKMIFDVESMKKAMVEFE-IDLQKMPLGKLSKRQIQSAYSILNEVQQAVSDGGs--------------- 72   chicken
AAQ23182   305 ASKLPAPVQNVISFIFNQKYFLETMAQMS-YDANKLPLGKLSKRTLMAGYETLKELAELATKPSmamsky---------- 373  Emericella nidulans
CAD21266   289 ICTLHPSVAKLMELIFNQQLMDNTMAALK-YDRNKLPLGKLSKATIMRGFQALKNLSELFADPAkasqy----------- 356  Neurospora crassa
Q9Y6F1     182 PCSLDPATQKLITNIFSKEMFKNTMALMD-LDVKKMPLGKLSKQQIARGFEALEALEEALKGPTdg-------------- 246  human
NP_956795  183 PCTLDAETQRLMRFIFDNDMFKEAMTSMD-LDIKKMPLGKLSKQQIAKGFEALEEIEAAIKKSEr--------------- 246  zebrafish
CAD59239  2144 KSQLPKELYDVMAQFCNVESISHQLKNLK-IDTDIMPLGRISKDLIQKAITVLGKLSEAVEQIRlieeheankrassftn 2222 Dictyostelium di...
Q09525     148 VEEVNEKLKELMKCICDEDVHLGLLKQLKfNEAFGRPIDCLSLAQLTTGYEILSKIEESIGGKSarrstrgrprv----- 222  nematode
NP_197639  450 HCKLDSFVANFIKVLCGQEIYNYALMELG-LDPPDLPMGMLTDIHLKRCEEVLLEFVEKVKTTKet-------------- 514  thale cress
NP_503401 1872 KNTEKDPIRRMIADISDAKTLKTYASQVQmYGGSSQPFGRFTKENIEKAKLVLDKLEKNANRIKqmveaqtgv------- 1944 nematode
Feature 1                                        ############# #############     ##############
1PAX        73 ---------------------------------eSQILDLSNRFYTL-IPHDFGMKKPPLLsn-leYIQAKVQMLDNLLD 117  chicken
1A26        73 ---------------------------------eSQILDLSNRFYTL-IPHDFGMKKPPLLsn-leYIQAKVQMLDNLLD 117  chicken
AAQ23182   374 -----------------------------gmqlrPAMEQLSNRYFTT-IPHVFGRNRPPVLdn-qaYIKREIELLETLTD 422  Emericella nidulans
CAD21266   357 -----------------------------glpyqQAVEHLSNTYYSV-IPHAFGRERPPVIaa-deQLKQEIELLENLSD 405  Neurospora crassa
Q9Y6F1     247 ---------------------------------gQSLEELSSHFYTV-IPHNFGHSQPPPIns-peLLQAKKDMLLVLAD 291  human
NP_956795  247 ----------------------------------SKFEELTNKFFTI-IPHNFGRNRPPVIsd-dsVLQSKKEMLLVLAD 290  zebrafish
CAD59239  2223 attvgsgvsgsggdststtdkpeepnfpplndvkESLIKLSNELYEL-IPHSNFSTERMVIlksakEITAKTTLLQNLDE 2301 Dictyostelium di...
Q09525     223 ------------------------adrvlavksdGPSLHDINKYYSL-IPHSFGFCVPPKIds-haKIQAERELLDALKG 276  nematode
NP_197639  515 ---------------------------------gQKAEAMWADFSSR-WFSLMHSTRPMRLhdvneLADHAASAFETVRD 560  thale cress
NP_503401 1945 -------------------------vesnlldayITTSELSGDYYSLiPSGEYEFSNLTRLdn-veEIARHRARLNRCQE 1998 nematode
Feature 1      #########             ########                                                  
1PAX       118 IEVAYSLLRggne------dgdKDPIDINYe--kLRTDIKVVDKDS-----------------EEAKIIKQYVKNTHAat 172  chicken
1A26       118 IEVAYSLLRggne------dgdKDPIDINYe--kLRTDIKVVDKDS-----------------EEAKIIKQYVKNTHAat 172  chicken
AAQ23182   423 MEITNSILKdask------medANPLDSQYag-lGMQEMTPLDHAS-----------------EEFRELEKYLSGTRGst 478  Emericella nidulans
CAD21266   406 LKEASNIMKvdkt------kfdVHPLDRQYq--gLKMQEMTPLDRAs----------------TEFAQLADYLVETRGnt 461  Neurospora crassa
Q9Y6F1     292 IELAQALQAvseqek--tveevPHPLDRDYq--lLKCQLQLLDSGA-----------------PEYKVIQTYLEQTGSn- 349  human
NP_956795  291 IEVAQSLKAesekakeemedtvPHPVDQNY----QSLKCSLNLVDKk---------------sKEYKIIEKYLKATGQeg 351  zebrafish
CAD59239  2302 LETVSKILIaa----------hQNTTMHPYd--yCFKALGASLEKLda-------------nsPEFGILKKYSENTGC-- 2354 Dictyostelium di...
Q09525     277 SIEASLELKdlkk-----tassKDIYQRLYe--rLPCHLEPVSEEIagkigdclamrgpthcyKLSLIDAFELKDPNEip 349  nematode
NP_197639  561 INTASRLIGdmrg------dtlDDPLSDRYk--kLGCKISVVDKES-----------------EDYKMVVKYLETTYEpv 615  thale cress
NP_503401 1999 IETATRLLCaae--------frQDLDRVDYirsaIQCEYRLETPDS-----------------DISQRLLQWIHNSGG-- 2051 nematode
Feature 1                                                                                      
1PAX       173 h---naYDLKVVEIFr-IEREGESQRYkp-------fKQLHNRQLLWHGSRTTNFAGILSQGLRIAPpeAPVTGYmfGKG 241  chicken
1A26       173 h---naYDLKVVEIFr-IEREGESQRYkp-------fKQLHNRQLLWHGSRTTNFAGILSQGLRIAPpeAPVTGYmfGKG 241  chicken
AAQ23182   479 ----hgVKYKVIDIFr-IERQGEHDRFksss---yagLKNSNRRLLWHGSRSTNYGGILSQGLRIAPpeAPVSGYmfGKG 550  Emericella nidulans
CAD21266   462 ----hgLNYQVEEIFr-IERQGEFDRFdqsdyadgkmKLKKNRKLLWHGSRSTNFGGILSQGLRIAPpeAPVNGYmfGKG 536  Neurospora crassa
Q9Y6F1     350 -----hRCPTLQHIWk-VNQEGEEDRFqa-------hSKLGNRKLLWHGTNMAVVAAILTSGLRIMP--HSGGRV--GKG 412  human
NP_956795  352 -----lTLVDVWEVD--RETEAERFREn---------DALENRKLLWHGTNVAVVAAILKSGLRIMP--HSGGRV--GRG 411  zebrafish
CAD59239  2355 ------TKKIVNIFK--LQRKGEVERFqa-------hKNLKNHFLLWHGSLTTNYLSILSQGLKIAPpeAPVTGYmfGKG 2419 Dictyostelium di...
Q09525     350 ----teAPVEVQEVPkkRGRKSTKTAApt-------vPPPTTKRLLWHGTRVTNVFSILMNGLQFPV--GDRCGLmfGNG 416  nematode
NP_197639  616 kvsdveYGVSVQNVFa-VESDAIPSLDd--------iKKLPNKVLLWCGSRSSNLLRHIYKGFLPAVcsLPVPGYmfGRA 686  thale cress
NP_503401 2052 ------KQAKVKMILe-ISPMLSTEKFep-------fVNDDNQKFLWHGTKATNLMSILKNGFLIDPpsACKNGNlfGSG 2117 nematode
Feature 1                                                                                      
1PAX       242 IYFADMVSKSANYCHTSq--aDPIGLILLGEVAL-GNMYELKNASHitk------lpkGKHSVKGLGKTAPDPtatt--- 309  chicken
1A26       242 IYFADMVSKSANYCHTSq--aDPIGLILLGEVAL-GNMYELKNASHitk------lpkGKHSVKGLGKTAPDPtatt--- 309  chicken
AAQ23182   551 VYFADMSSKSANYCWSHn--sDHKALLLLGDVELgDPIYELYDSDYnagen---akkeGKIATLGKGRSIPAGwkdagci 625  Emericella nidulans
CAD21266   537 VYLADMSSKSAGYCCAYm--sNGTALLLLCEAELgDPIQELTGADYnageh---akqkGMLSTWGKGGTGPLKwkdagav 611  Neurospora crassa
Q9Y6F1     413 IYFASENSKSAGYVIGMkcgaHHVGYMFLGEVAL-GREHHINTDNPslks-----pppGFDSVIARGHTEPDPtqdtel- 485  human
NP_956795  412 IYFASENSKSAGYVRPS----NKIGIMFLNEVAL-GKEYTITRDDPslrk-----apaGYDSVIARGNQEPDPskdvfi- 480  zebrafish
CAD59239  2420 IYFSDMFRKSINYCGSWds-sSANSFLLLSEVAL-GTMKEFKSAHYmes------petGTNSTKGVGKTGPNFddsii-- 2489 Dictyostelium di...
Q09525     417 VYFANVPTKSANYCCPEa---SKRVFMLLCEVET-ANPLVLYESEIdadek---mekaKKTSVYAAGKHTPRDt------ 483  nematode
NP_197639  687 IVCSDAAAEAARYGFTAv--dRPEGFLVLAVASL-GEEVTEFTSPPedtk----tledKKIGVKGLGRKKTEEsehfm-- 757  thale cress
NP_503401 2118 IYLADSFEKSTHYCQPSa---GGINYMLVCQTAL-GKVRTLDTIPYhymnqssssaekYEDTLHYIGDRFPAGslt---- 2189 nematode
Feature 1                                                          
1PAX       310 --tldgVEVPLGNGISTgin------dtcLLYNEYIVYDVAQVNLKYLLKLK 353  chicken
1A26       310 --tldgVEVPLGNGISTgin------dtcLLYNEYIVYDVAQVNLKYLLKLK 353  chicken
AAQ23182   626 hphlkgIQVPDADSGTTdhkt----dqgyLLYNEYIVYDVAQIRLRYLFFVD 673  Emericella nidulans
CAD21266   612 npalqgVMMPDTSVKPGntnv----pgcsLLYNEYIAYDVAQIRLRYLFRVK 659  Neurospora crassa
Q9Y6F1     486 eldgqqVVVPQGQPVPCpefs-----sstFSQSEYLIYQESQCRLRYLLEVH 532  human
NP_956795  481 eldgkkVVVPQGKVIKQqqye-----gshFYNSEYLIYKESQCRIRYLLELK 527  zebrafish
CAD59239  2490 --lnngVAIPLSPPEQVkgdt----sdyhLEMNEYIVYDVSQIRMRYLVEVS 2535 Dictyostelium discoideum
Q09525     484 ------VEINGIPAFKSnleti--eeetrLLYDEYVMFNKEHFKIKYVVEVK 527  nematode
NP_197639  758 --wrddIKVPCGRLVPSehk------dspLEYNEYAVYDPKQTSIRFLVEVK 801  thale cress
NP_503401 2190 ---ndgVGMPLLPLRKRdpiqgsnygfgtLDFSEYIVRNPNRVLPKYIVMYK 2238 nematode

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