6R9D,5IZ2,2MX9


Conserved Protein Domain Family
Spidroin_N
?
pfam16763: Spidroin_N 
Major ampullate spidroin 1, spider silk protein 1, N-term
Spidroin is produced by a number of arachnids. Spidrions are made up of repetitive segments flanked by conserved non-repetitive domains, and this domain is the conserved non-repetitive region. Aggregation to form the rigid silk occurs due to association at the repetitive regions, and the N-terminal domain is necessary to prevent premature aggregation during storage before extrusion. This N_terminal region inhibits precocious aggregation and then accelerates and directs self-assembly as the pH is lowered along the extrusion duct.
Links
?
Statistics
?
PSSM-Id: 465262
Aligned: 22 rows
Threshold Bit Score: 119.708
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
?
Program:
Drawing:
Aligned Rows:
Download Cn3D
PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
6R9D_B      9 PWTNPGLAENFMNSFMQGLSSMPGFTASQLDDMSTIAQSMVQSIQSLAAQGRASPNKLQALNMAFASSMAEIAASEeggg 88   Euprosthenops aus...
ADM14317   23 PWETPEMAENFMNNVRENLEASRIFPDELMKDMEAITNTMIAAVDGLEAQHRSSYASLQAMNTAFASSMAQLFATE---- 98  
ADM14315   32 PFANKIMAEDFMNKFTNQLANSPYFSSQQKEDMSSIKDELISVIESMDSAHKSSAAKLQAMNMAFASAIADIAATEayga 111 
Q2V0S3     35 VFSSPSLASGFLGCLTTGIGLSPAFPFQEQQDLDDLAKVILSAVTSNT--DTSKSARAQALSTALASSLADLLISEssgs 112  Nephila clavata
Q25C18     30 VFSSPNLASGFLQCLTFGIGNSPAFPTQEQQDLDAIAQVILNAVSSNT--GATASARAQALSTALASSLTDLLIAEsaes 107  Argiope bruennichi
ADM14313   31 PWTDEAKGKKFLSTFLDYALDHGLFPQQERDDLEAISQNLIPVFRKTMDSGGNAAAKMKALNMAFASSIAEIAVQEggag 110 
ADM14314   29 PWSNAKTAEIFISKFISAILDSNAFTREQKEDMMSIGETIIPAMEKMSGSSKSIHAKLTALNMAFASSVAEIAVVEeggs 108 
ADM14324   27 PWTDTATAESFISSVMSSVANQGCLSYDQIDDMQAVGDTMLATMDNLVRSGKSSSHMLKAMNMAMGTSIAEIVADgg--g 104 
ADM14328   20 IWGTPGAGKSVTGSIVQCAGQSGVFSGDQMQDLGDMADAVNRQLDRLG--PNAPDHRLKGVTTMMAAGIADAAVNSpg-q 96  
ADM14326   18 VWSSPQMAENFMNGFSMALSQAGAFSGQEMKDFDDVRDIMNSAMDKMIRSGKSGRGAMRAMNAAFGSAIAEIVAANgg-- 95  

6R9D_B     89 SLSTKTSSIASAMSNAFLQTTGVVNQPFINEITQLVSMFAQ---AGMN 133  Euprosthenops australis
ADM14317   99 QDYVDTEVIAGAIGKAYQQITGYENPHLASEVTRLIQLFREeddLENE 146 
ADM14315  112 DISLETSAIANALSEAFLQTTGVVNKRFISEIQELIYMFAQdasVQSN 159 
Q2V0S3    113 SYQTQISALTNILSDCFVTTTGSNNPAFVSRVQTLIGVLSQ---SSSN 157  Nephila clavata
Q25C18    108 NYSNQLSELTGILSDCFIQTTGSDNPAFVSRIQSLISVLSQ---NADT 152  Argiope bruennichi
ADM14313  111 SIEEKTQAVSEALAHAFLQTTGSVNIQFIKEIRALITLFAK---EGQD 155 
ADM14314  109 DINEKTYAIVAALNQAFLDTTGKVNKQFIAEIRDLVKMFAS---ANEE 153 
ADM14324  105 NLGSKVSCISNALSSAFLQTTGSVNTQFVNEIVSLISMFAQ---ADTN 149 
ADM14328   97 SLDVMINTISGCMTQAMSQAVGYVDQTLIREVAEMVNMLAN---ENAN 141 
ADM14326   96 -kEYQIGAVLDAVTNTLLQLTGNADNGFLNEISRLITLFSS---VEAN 139
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap