1UUO,1D3G,1D3H,1F76,1TV5


Conserved Protein Domain Family
DHOD_2_like

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cd04738: DHOD_2_like 
Click on image for an interactive view with Cn3D
Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires FMN as co-factor. DHOD divides into class 1 and class 2 based on their amino acid sequences, their cellular location and their natural electron acceptor used to reoxidize the flavin group. Members of class 1 are cytosolic enzymes and multimers, while class 2 enzymes are membrane associated, monomeric and use respiratory quinones as their physiological electron acceptors.
Statistics
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PSSM-Id: 240089
Aligned: 91 rows
Threshold Bit Score: 228.537
Created: 17-Jul-2006
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 18 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:1F76_A; Escherichia coli DHOD binds FMN and orotate

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                       #   #           
1UUO_A       20 PGLQRLLd--PESAHRLAVRVTSLgllprat----------fqdsdmlEVKVLGHKFRNPVGIAAGFDKNGEAVDGLYkl 87  black rat
1F76_A        7 RKALFQLd--PERAHEFTFQQLRRitgtpfeal-------vrqkvpakPVNCXGLTFKNPLGLAAGLDKDGECIDALGax 77  Escherichia coli
CAA46230     70 PLFHAFTt--PEFSHRVAILAASWgitpkdr----------vaddpslAVEVWGKKFCNPIGLAAGFDKQADAISGLLnf 137 fission yeast
NP_560615     8 GKYIHYIh--PEIAHRLGALLFSIplpsc---------------kcerSWEIGGVKVCGPVGVAAGLDKTGLYSRFLSff 70  Pyrobaculum aero...
AAP39962     68 PLIRTFTd--AESGHKLGIFFMKYglsprlldd------gkndqsdvlGVQVFGHKLKNPIGLAAGLDKDGEAIESLFnc 139 Candida albicans
CAG81200     77 PILRLCTd--AETSHRLGIEILANgmspkqrqedneidpnhllevtifANSKRPLTLRTPIGVAAGLDKHGQAIDGLFgl 154 Yarrowia lipolyt...
EAL22168     67 PLMRLVAd--PEQGHKLAVRVLAWdkwarprd--------mgvdgaelQAELFGMHLKNPVGIAAGFDKDAEAIDGLFdl 136 Cryptococcus neo...
ZP_00533973   7 RPLFFFId--PEKVHHQVILLLKFgfsipgikqff--rylttvkqpnlRRELFGLTFPNPVGIAAGFDKNAHCYNDLAdl 82  Chlorobium phaeo...
XP_759362   105 PALKAFLd--PESAQKLAVKMLETglaprdl----------vdddavlETELFGRKLSNPIGLAAGFDKQAEAIDGLLdl 172 Ustilago maydis 521
XP_961804   105 PPLLRTIfpdAEEAHHVGTAALKGlyetglhire----rvpespngplSVNVFGKQLLNPIGISAGLDKDAEIPDPLFal 180 Neurospora crass...
Feature 1               #                        # ###                                          
1UUO_A       88 GFGFVEVGSVTPQPQEGNPRPRVFRLPEdQAVINRYGFNSHGLSVVEHRLRarqqkqaq--------------------- 146 black rat
1F76_A       78 GFGSIEIGTVTPRPQPGNDKPRLFRLVDaEGLINRXGFNNLGVDNLVENVKkahy------------------------- 132 Escherichia coli
CAA46230    138 GFSYLEIGSVTPKPQPGNPKPRYFRLKPdLSVINRYGFNSIGHDAILAKIQkrvrkyiaktspqllkqfdan-------- 209 fission yeast
NP_560615    71 CPGFIVVGSTLPRARRGNRPPRAARLRP-YSMVNAMGLNSPGIAKVVSRLRglr-------------------------- 123 Pyrobaculum aero...
AAP39962    140 GFSYVEIGSITPEPQPGNPQPRFFRLPKdDAVINRYGFNSSGHFNVLATLKlrfnkllnkfgtshs-------------- 205 Candida albicans
CAG81200    155 GFAYVEVGSVTPEPQDGNPKPRFFRLPKdDAVINRYGFNSEGHFAVMGRLKqrllhalgheqpq---------------- 218 Yarrowia lipolyt...
EAL22168    137 GFGYVEVGSVTPEPQPGNPKPRFFRLEEdDACINRYGFNSLGHGHALARLRlrlakfaqdhpslfpsplp---------- 206 Cryptococcus neo...
ZP_00533973  83 GFGFIEIGTVTPKGQAGNPKKRLFRLPKdHALINRMGFNNKGLDAAVKNLKkrkt------------------------- 137 Chlorobium phaeo...
XP_759362   173 GFGFIEIGSVTPEPQPGNPQPRYFRLIEdNACINRFGFNSEGHNVILSRLRdrirrwllhsssvanlqdallaspdsasv 252 Ustilago maydis 521
XP_961804   181 GAGVVEVGGCTPFPQEGNPKPRVFRIPSvDGLINRYGLNSRGADAMATRLRerlrkfarsvgltdnevl----------- 249 Neurospora crass...
Feature 1                                                                               #  # #  
1UUO_A      147 ------------------------ltadglpLGINLGKnkts-----edaaADYAEGVRTLGPla--dYLVVNVSSPNta 195 black rat
1F76_A      133 ----------------------------dgvLGINIGKnkdtp---veqgkDDYLICXEKIYAya--gYIAINISSPNtp 179 Escherichia coli
CAA46230    210 ----------pasctdpavlgvprslipnkfLGINLGKnkng------neiEDYVEGVRTFGNfa--dILVINVSSPNtp 271 fission yeast
NP_560615   124 -----------------------------ypLFISIAGfs----------aEDFAVQLLYLQRhfkpdAVEINISSPTyr 164 Pyrobaculum aero...
AAP39962    206 ----------------seqhpfsnafqqgklLGINLGKnkfg------devNDYVKGVERLGPya--dVLVINVSSPNtp 261 Candida albicans
CAG81200    219 ------------------hedtrhsldknkvLAVNLGKnktg------devSDYTQGVTRFANls--dALVVNVSSPNtp 272 Yarrowia lipolyt...
EAL22168    207 -------------anlvppaglprslragqlLAVNLGKnkasd----pdsnDDYIRGVRTLGPfa--dVVVINVSSPNtp 267 Cryptococcus neo...
ZP_00533973 138 ----------------------------kaiIGGNLGKntltp---nqeavNDYLTVFKGLFDhv--dYFVVNVSCPNit 184 Chlorobium phaeo...
XP_759362   253 narqliathpkstsafvdatdlprslrpakmLGINLGKnktsn----eesvDDYVKGVERLGPya--dMIIVNVSSPNtp 326 Ustilago maydis 521
XP_961804   250 -------------neegtdgippgslhpgrlLCVQIAKnkktdekdvnaviRDYVYCVDKLAPya--dVLVVNVSSPNtp 314 Neurospora crass...
Feature 1                                                  #                            ###     
1UUO_A      196 glrslqgktELRHLLSKVLQErdalk--------gtrkpAVLVKIAPDLta-qDKEDIASVARELgiDGLIVTNTtvsrp 266 black rat
1F76_A      180 glrtlqygeALDDLLTAIKNKqndlqa------xhhkyvPIAVKIAPDLse-eELIQVADSLVRHniDGVIATNTtldrs 252 Escherichia coli
CAA46230    272 glrnlqkksALSTLLTAVVSErnkln---------sphpPVLVKIAPDLne-eELTDIADVLKKCkiDGVIVGNTtvqrp 341 fission yeast
NP_560615   165 --------gFWRDAPTLVKTEf-----------------PVFVKVGPSA----DIRSVVRRVREVg-WGLVVTNTlpved 214 Pyrobaculum aero...
AAP39962    262 glrdlqseaKLTNLLTTVVKErnvlgkn-----llgnkpPVLVKVAPDLte-pEIESIANSAKEAkvDGIIISNTtiqrp 335 Candida albicans
CAG81200    273 glralqgeeRLAKLLTAVVAErnkvqf-------antytPILVKIAPDLse-sEIVSIAAAAKQSkiDGIIVSNTtiqrp 344 Yarrowia lipolyt...
EAL22168    268 glralqgkqQLERLLNDVVEErnkiaq-------gtglpKIAVKVASDLse-dELADVASAVRSSgvEGVIVSNTtirrk 339 Cryptococcus neo...
ZP_00533973 185 dlrelqdqeALVNILEKIQEVnqak----------sqpkPVLLKVSPDLne-sQLDEVIDLAHNKliDGVVAVNTtitrq 253 Chlorobium phaeo...
XP_759362   327 glrrlqrrgVLEDLLTQVVRArdgmveshlrfsdkkvavPLLVKIAPDLse-eELHDVADAALKSgiDGLVISNTtisrp 405 Ustilago maydis 521
XP_961804   315 glrdlqatePLTKLLSAVVDAaqqtk--------rktkpRVMVKVSPDEdddtQMEGVVEAVWNSgvDGVIVGNTtkrrt 386 Neurospora crass...
Feature 1                               #                                        #              
1UUO_A      267 vgl---------qgalrsetGGLSGKplRDLSTQTIREMYALtq------------grIPIIGVGGVssGQDALEKIqaG 325 black rat
1F76_A      253 lvq---------gxkncdqtGGLSGRplQLKSTEIIRRLSLEln------------grLPIIGVGGIdsVIAAREKIaaG 311 Escherichia coli
CAA46230    342 ktlk--------stshveetGGLSGPplKPIALNTLRTLRKHls------------sdIPIIGCGGIssGKDAIEYAraG 401 fission yeast
NP_560615   215 p-------------rlsvgrGGLSGLllYKYGFKLLERVRRLag------------kdVPIIYSGGLytCGQLREVLk-L 268 Pyrobaculum aero...
AAP39962    336 vdrll-----ttdkqlinqaGGLSGKplKPLSLKALRTLRKYtkd-----------sdLVLIGCGGIsnGKDALEFGkaG 399 Candida albicans
CAG81200    345 ehlr-------sqpylsaetGGLSGAplKPIALKAIKTLRKNig------------deITIVGCGGIsnGKDAIEFAraG 405 Yarrowia lipolyt...
EAL22168    340 elnl--------vsgnqdqiGGLSGKplFPYALNALKTLRPLlp------------psVPIIGCGGIssGSDALTMAnaG 399 Cryptococcus neo...
ZP_00533973 254 glqts------dseiksignGGLSGLplKQRSTEVIRYLSQKsg------------kaFPIIGVGGIetPEDAIEKIkaG 315 Chlorobium phaeo...
XP_759362   406 aslr--------ssehvretGGLSGApvKPLALKALTTVHKRlq------------gkLPIIGCGGIsnGQDALDYAkaG 465 Ustilago maydis 521
XP_961804   387 givpkgvkliddepkilheeGGFSGPalFDRTVNLIGRYRKMldgyalksesdkspaqKVLFASGGItnGEQALRVLnaG 466 Neurospora crass...
Feature 1             ##                 
1UUO_A      326 ASLVQLYTALIFlGPPVVVRVKREL 350 black rat
1F76_A      312 ASLVQIYSGFIFkGPPLIKEIVTHI 336 Escherichia coli
CAA46230    402 ATMVQVYTALGYdGPVIAHKIKQEI 426 fission yeast
NP_560615   269 ADAAEVLTSILYfTPYVLKLLNRCP 293 Pyrobaculum aerophilum str. IM2
AAP39962    400 ATFIELYTAFAYkGPGLVGKIRDEL 424 Candida albicans
CAG81200    406 ATFVQVYTALAYqGPGLPVHMKQEI 430 Yarrowia lipolytica CLIB99
EAL22168    400 ASIVQVYTSFGFrGVGTPRLIKDEI 424 Cryptococcus neoformans var. neoformans B-3501A
ZP_00533973 316 ADLIQVYTGFIYeGPFIAKRINRAL 340 Chlorobium phaeobacteroides BS1
XP_759362   466 ASAIELYTSFGYqGVGLPRRLKDEL 490 Ustilago maydis 521
XP_961804   467 ASVAMVYTAMVYgGSGTITRIKSEM 491 Neurospora crassa OR74A

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