4WFT,1WHN,6EI8


Conserved Protein Domain Family
DSRM_DUS2L
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cd19871: DSRM_DUS2L 
double-stranded RNA binding motif of tRNA-dihydrouridine(20) synthase [NAD(P)+]-like (DUS2L) and similar proteins
DUS2L (also known as dihydrouridine synthase 2 (DUS2), up-regulated in lung cancer protein 8 (URLC8), or tRNA-dihydrouridine synthase 2-like) catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. It negatively regulates the activation of EIF2AK2/PKR. DUS2L contains an N-terminal FMN-binding domain and a C-terminal double-stranded RNA binding motif (DSRM) that is not sequence specific, but highly specific for dsRNAs of various origin and structure.
Links
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Statistics
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PSSM-Id: 380700
Aligned: 29 rows
Threshold Bit Score: 68.0677
Created: 23-Oct-2018
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
Download Cn3D
 
putative RNA
Conserved site includes 19 residues -Click on image for an interactive view with Cn3D
Feature 1:putative RNA binding site [nucleic acid binding site]
Evidence:
  • Comment:Based structure evidence that Homo sapiens TARBP2 (5N8L) binds siRNA.
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1         # ##  ##  ##     ##      #  ## #                   ####  ##            
4WFT_C         33 TPKMCLLEWCRRek-laQPVYETVQRplDRLFSSIVTVA-EQKYQSTLWD-KSKKLAEQAAAIVCLRSQGL 100  human
NP_572950     394 LPKTQLYVHAVKtg-ksPPAYETQQC--DKLFRSICTYD-GQRFSSSFWE-KNKKQAEQGAALVALLHLGQ 459  fruit fly
EDQ87804      401 VPKEVLMAYTQRmq-leEPSFSSTPV--NKKFVAVCHWL-GEQYATSAGH-GNRRYAEQAAALVALIGRGM 466  Monosiga brevicollis MX1
EFX69706      379 LPKTVLHEYACKaqhskLPLYHSEQV--DKLFFSTVVVE-GQRYANRYLE-KNKRSSEQAAALACLHALNL 445  common water flea
KCV72572      407 PPKQILNGLTSD-----SLKYETVRCdtRRAFRSTVTLDsGKAFGSENWF-MNKKTAEHAAAVVALRYGLA 471  Fonticula alba
KHJ48604      952 TPKVLLTEWSKQhf-rrLPIFSTESRvdDSKFISTVDVG-GFKFKSGCWA-SNRRYAEQAAALVAIFYFRL 1019 pig whipworm
XP_018012360  401 LPKMVMNRYVSQnd-laEPVYSAHNK--DRFFIGHVELD-GVIYQTSCIE-KSRRYAEQAAAMVYLHAHEL 466  Hyalella azteca
RDD40302      370 TPKSLLYQWSKKng-ydAPIYSSNVEpqSKLFRSHVTIN-GEKYSSQGRGqKNKRSAEQLAAYTCLKSLKI 438  Trichoplax sp. H2
OTF79079      350 YPKTILNRWLMKnn-fkNPHYETKQI--EKKFHSILHFQ-GKCYTTPYLE-TTKKTAEQSAALVIIIKLGL 415  Euroglyphus maynei
CDI97886      367 LPKQILMRHCKRkq-idFPTYSTVENkaSRTFSSIVTLN-GASYAHKIAS-TTKRFAEQAAALACLTHLGI 434  Echinococcus multilocu...

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