5OGS


Conserved Protein Domain Family
Mcl1_mid

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pfam12341: Mcl1_mid 
Minichromosome loss protein, Mcl1, middle region
Mcl1_mid, or the middle domain of minichromosome loss protein 1, is the domain that lies between a 7-bladed beta-propeller at the N-terminus, family WD40 pfam00400 etc, and a Homeobox (HMG) domain, pfam00505, at the C-terminus. The full length proteins with all three domains are referred to as DNA polymerase alpha accessory factor Mcl1, but the exact function of this domain is not known.
Statistics
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PSSM-Id: 463539
Aligned: 108 rows
Threshold Bit Score: 201.262
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5OGS_A        107 KPFQSGSTpLHl-----------T-HRFMVWNSIGIIRCY-NDEq-----dNAIDVEFHDTS----IHHATHLS-NTLNY 163 
EEC44446      592 PAFGPSSTsLEl------------tRRFLCWNHIGSVTFL---RgqaginrSTIDIHFTDSA----FRRPVSFT-DNMGF 651 
EED90214      158 KTFAPSSTpITe------------pRRILCWNHVGVVTSY---PdpespqySTIDIAFHDAAglvgGRRPVTFM-DNLGF 221 
CBZ08475      588 YSFQVGATpAGee-----------gNCYLAYNSVGYIHCSrDA----------TTVHFHDIS-----HPAVRLQ-LRGTV 640 
Q4E5R7        564 YSFQIGATpVGee-----------gSCYLAYNSVGYIHSTaDG----------TNIHFHDMS-----IQAVRIL-ERGTI 616  Trypanosoma c...
Q4GYD0        615 yfFQIGATpPGee-----------gSCYLAYNSVGYIHCTaEA----------TTIHFHDMS-----LQAVRVL-ERGTM 667  Trypanosoma b...
XP_004358825  527 ASFQPGSTlfl----------nnKkRYFMAYNMIGCIVKReEEdekl---pgsIEIEFNEAS----VHRKVTIT-DNNML 588 
EAX94780      545 gPFMPGSSqd-----------ydGsRRFLCWNETGVIFLReIDEd-----rEAIDVEFADVF----SNRNVSFS-NDRHF 603 
EWS72657      475 diiyPSSVsKQl------------nRSCILWNLVGQIILReEDRnl------fLEFDFPDKE----FHSRITIK-NLHNY 531 
XP_003291016  425 ESFQIGST-LLnvlnnpktlnlkTkRYYMAYSMLGKIVKReESPssn--epSSIEIEFHETG----YNKKITFSdINHNL 497 
5OGS_A        164 TIADLSHEAILLac-eSTDE--L--------------------------------ASKLHCLHFSSWDs--SKEWIIDLP 206 
EEC44446      652 ILGSLGEDGGIFat-dLAEDedIdeedddmdglnvsaatkaavkrsrkgpsnkptGSSIYFHRFETFGslrDKDWYLTLP 730 
EED90214      222 IVGTLGDEGAFFat-------dKggs--------------------------gnkGSQVYFNRFETFGrnaDKDWSVSLP 268 
CBZ08475      641 LMGTLSPVGAAFivlpADPTeaQgsvd-------------------------eapRLSVLYHAFTPLGa--QSEWRVALL 693 
Q4E5R7        617 LMAALSPVGAAFvl-tQDAe-mDsvd--------------------------dtpRLTLYYRTFVALGa--QSDWRVRLY 666  Trypanosoma c...
Q4GYD0        668 LMASLSPVGAAFvi-aQEATdmEsvdd-------------------------lvpRLTIYYRTFVSIGl--QPDWRLRLH 719  Trypanosoma b...
XP_004358825  589 DMGALGEKGAIFas-sRK--------------------------------------NLLHFNAFDSLGa--SSSWTYTIA 627 
EAX94780      604 LLATLNKEGFCAa-------------------------------------------SRTYFQYRSNNPksiPSEFSHKFT 640 
EWS72657      532 SMAAMNRQGFILas-kAINSsqEyeseedfer--------------fdfhqdaysYSCIYFQSLSKSDk---TLWSLKLG 593 
XP_003291016  498 RLSSLGPNGAVFat-kYLQNekEeyeqqqqeliekqk----nsdekdigsqikplESVIMFKPFDTLGd--TTGTEWSLT 570 
5OGS_A        207 qNEDIEAICLgqgwAAAATSALLLRLFTIGGVQKEVFSLAGPVVSMA-GHGEQ------------LFIVYHRGTG-FDGD 272 
EEC44446      731 dGERALGCASgegwAAVVTSRRFLRLFSSGGNQGEVLWLNGHPVTMA-GRGRF------------VAVVYHESTPlPDGT 797 
EED90214      269 sGERVLGCATgrgwGAVMTSRRYLRLFTTAGIQGPVLWLSGEPVTVV-GRDRF------------VAVFYHRSDPtQDGT 335 
CBZ08475      694 pGETVRCMAAgiryVAVAT-SHYLRIFSLSGLELAVLSKSQRIVTMV-GTSSRklmssfkadfdpLVIIS------LTGT 765 
Q4E5R7        667 pGETVRCLTAgirfTAVAT-SRYLRLFSLSGLELAVLSLFPRIVAMV-GTNSSkimhsfkadfdpLAVCY------LESG 738  Trypanosoma c...
Q4GYD0        720 tGEVVRCIATgvryTAVAT-SRYLRIFSLSGLQLAVISLFPRIVAMV-GTNSKkvmqgygadfdpLAVCY------LEGG 791  Trypanosoma b...
XP_004358825  628 aNDPIVGVAIgskyIAACSHHRTVRIFTLGGVQFTQLSIGGDFVTMSiSCKDV------------LALVYGTADQm---- 691 
EAX94780      641 dSETIDLIAIgkrwVAVATELGRIHIFKSSGFEYASLSLPDRLLTMV-GGKDR------------LFVVF---------G 698 
EWS72657      594 qDENVETVAIgdgwCAVQTDLQYIRIYSFSSMEQHCFCIDKPAVCIS-GYKNI------------LAIVYLEGEP-IYGC 659 
XP_003291016  571 dTEEVSGVSIsknfIVSVSSNRTLRLFSLGGIQMNLFTLPGDLVTMN-TFDDT------------LAIVYHRSNA-LNDN 636 
5OGS_A        273 QCLGVQLLE--LGKKkkQilhGDPLP-LT----RK-------SYLAWIGFSAEg--TPCYV-DSEGIVR--MLN------ 327 
EEC44446      798 QKLGYLVLD--AMANrvVa--KGPVScIS----GA-------STLSWLGFSNDg--SLLAM-DSDGMLS--MLVcassld 857 
EED90214      336 QQLGYSIID--GINGttIt--KGDVSgIS----PG-------GSLTWAGFTEVc--ALSVM-DSDGMLS--MLarp--ap 393 
CBZ08475      766 GELQMEVIDv------gAr--TSALP--PrtvpLTelpdgstHQLQWLGWSEDg---LLHIvDTAGVVR--QFTedw--- 827 
Q4E5R7        739 GEMRLQVLDv------gSr--SVVLP--PvvvpLTthsdgslHQLQWMGWSEDg---PLHFaDTAGVLR--MFTfnw--- 800  Trypanosoma c...
Q4GYD0        792 GELRLQVLDv------gSr--SVVVP--Att-vPVtt----tHQLQWMGWSEDg---PLHIaDTAGVLQ--MFTqnw--- 848  Trypanosoma b...
XP_004358825  692 ---TLVCQD--LNTGniIy--QGPIC-IS----TN-------ATLKWIGFSNNsdtTLTTV-DSNSVVR--TLTr----- 744 
EAX94780      699 DTLDYWLLDipNri--kLa--SGVIP-V------A-------KPLRWVTFDEN---DNVYAlGNDKILVelVFD------ 751 
EWS72657      660 QSIKLKFFD--VNSGemIk--EIGVP-LT----PF-------TTLTWFGFSEEg---LVLTkDSKGVIR--ALI------ 712 
XP_003291016  637 QSMNVWWIN--LANGkqIy--HDSLS-IS----PS-------SSLSWIGFSDNg--LLTTM-DSIGVVR--QLSngw-yn 694 
5OGS_A        328 -R---GLGNtWTPI------------------------------CNTREhCKg----K-S--------DHYWVVGIHEnp 360 
EEC44446      858 aEgptEKHWeWMPM------------------------------LDTVG-LRk---sR-D--------DSFWPVTVYD-- 892 
EED90214      394 tEqpsINIGnWVPM------------------------------LDTMG-LKk---lM-S--------DIYWPVEVHG-- 428 
CBZ08475      828 -------ggsWVPV------------------------------YDPRTlVDqs--------------yaLWVYGVSE-- 854 
Q4E5R7        801 -------ggsWIPV------------------------------LDPRCmADqt--------------ynLWIWGVSD-- 827  Trypanosoma c...
Q4GYD0        849 -------ggsWVPV------------------------------YDPRCmNDqt--------------ynLWIWGVCD-- 875  Trypanosoma b...
XP_004358825  745 gWptkQAPLqWSPL------------------------------MDFKQmATklsstT------------CWVVGLND-- 780 
EAX94780      752 ------FGFhWQAMsnlrnvisegkveenenksdesdesdlgldIDKKKsTNddgsyQlDhaekeiytD-FWCVSISD-- 822 
EWS72657      713 ------GYSnWTPI------------------------------YEQPH----------N--------KNFWLKGMVD-- 736 
XP_003291016  695 nQsstSFLQ-WTLI------------------------------MDLRK-CQkphslD-L--------YTYWIIGLNT-- 731 
5OGS_A        361 QQLRCIPCK-Gs---rFPPTlPRPAVAIL------SFKLP 390 
EEC44446      893 GKLVCVPLK-Ggm--kHPDAvRRPVTAAL------GFRLP 923 
EED90214      429 GKLVCVLLR-Ggr--eYPDAaRRPVTTTL------SLRIP 459 
CBZ08475      855 S--ALLAYRySrddpsYPAAaASGLSTEL---------VP 883 
Q4E5R7        828 E--AVFAYRsCksdppYPAAvASGLPTehvrlflpltrcg 865  Trypanosoma cruzi
Q4GYD0        876 E--SMLVYRsCkddppYPAAvASGLPTervslflpllhsg 913  Trypanosoma brucei
XP_004358825  781 SHIHCIVCTd------FPQTlPRPILTPI------QINLP 808 
EAX94780      823 NKLFGCFLK-En---kVPHAyPLQGLSEV------Klmpl 852 
EWS72657      737 YKLAGFLLP-Kd--------eLEPRLTQIyhekcfDMQLP 767 
XP_003291016  732 TDLYSIFCT-G-----YPQT-PKCTHNYV------KIEAP 758 
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