1M63,1MZW,1IHG,1QNG,1AK4,1RMH,1CWA,1E3B,1E8K,1CYN,1IST,2RMC


Conserved Protein Domain Family
cyclophilin_ABH_like
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cd01926: cyclophilin_ABH_like 
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cyclophilin_ABH_like: Cyclophilin A, B and H-like cyclophilin-type peptidylprolyl cis- trans isomerase (PPIase) domain. This family represents the archetypal cystolic cyclophilin similar to human cyclophilins A, B and H. PPIase is an enzyme which accelerates protein folding by catalyzing the cis-trans isomerization of the peptide bonds preceding proline residues. These enzymes have been implicated in protein folding processes which depend on catalytic /chaperone-like activities. As cyclophilins, Human hCyP-A, human cyclophilin-B (hCyP-19), S. cerevisiae Cpr1 and C. elegans Cyp-3, are inhibited by the immunosuppressive drug cyclopsporin A (CsA). CsA binds to the PPIase active site. Cyp-3. S. cerevisiae Cpr1 interacts with the Rpd3 - Sin3 complex and in addition is a component of the Set3 complex. S. cerevisiae Cpr1 has also been shown to have a role in Zpr1p nuclear transport. Human cyclophilin H associates with the [U4/U6.U5] tri-snRNP particles of the splicesome.
Links
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Statistics
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PSSM-Id: 238907
Aligned: 37 rows
Threshold Bit Score: 289.157
Created: 13-Oct-2004
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved Features/SitesClick to see Conserved Features Help
 
active site
Conserved site includes 6 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:1AK4_A, Homo sapiens cyclophilin A bound to amino terminal domain of HIV-1 capsid, contacts at 3.5 A
  • Structure:1M63_C, Homo sapiens cyclophilin A, residues for recognition of calcineurin, contacts at 3.5 A
  • Citation:PMID 8980234
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                              ##    #                
1M63_C      4 PTVFFDIAVDgePLGRVSFELFADKVPKTAENFRALSTGEkg-------fgYKGSCFHRIIPGFMCQGGDFTRHNGTGG- 75  human
AAP73848   37 PVVFFDVTIGsiPAGRIKMELFADIVPKTAENFRQFCTGEhrksg--lpqgYKGCQFHRVIKDFMIQGGDYMKGDGTGC- 113 Japanese rice
1MZW_A     11 PVVFFDVSIGgqEVGRMKIELFADVVPKTAENFRQFCTGEfrkdg--vpigYKGSTFHRVIKDFMIQGGDFVNGDGTGV- 87  human
AAP21373   32 PVVFFDVSIGgiPAGRIKMELFADIAPKTAENFRQFCTGElrkag--kplgYKECQFHRVIKDFMVQSGDFLKNDGSGC- 108 thale cress
NP_610224  17 PVVFFDIAVGttEIGRMIFELFADTVPRTAENFRQFCTGEyrpdg--vpigYKGASFHRVIKDFMIQGGDFVQGDGTGV- 93  fruit fly
B53522    179 PRVFFDISIDkkPAGRIEFELFADVVPKTAENFRALCTGEkgtgrsgkplyYKGCPFHRIIPQFMCQGGDFTRMNGTGG- 257 Toxoplasma gondii
EAL18455   13 PIVFFDISIGdtPAGRIKMELFDDITPKTAENFRQLCTGEhrins--vpqgYKKATFHRVIPQFMVQGGDFVRGDGTGS- 89  Cryptococcus neofo...
1QNG_A      4 SKVFFDISIDnsNAGRIIFELFSDITPRTCENFRALCTGEkigsr-gknlhYKNSIFHRIIPQFMCQGGDITNGNGSGG- 81  malaria parasite P...
1AK4_A      4 PTVFFDIAVDgePLGRVSFELFADKVPKTAENFRALSTGEkg-------fgYKGSCFHRIIPGFMCQGGDFTRHNGTGG- 75  human
CAE76450   12 PLVFFDITLGgePLGRITFELFKDVVPRTAENFRQFCTGEsknnl-grpqgYKGSKFHRIIPNFMCQGGDFLNGDGTGSt 90  Neurospora crassa

Feature 1                                        # #       #                                  
1M63_C     76 KSIYGEKFEDENFILKHtGPGILSMANAGPNTNGSQFFICTAKTEWLDGKHVVFGKVK-EGMNIVEAMERFgsr---ngk 151 human
AAP73848  114 TSIYGTKFDDENFIAKHtGPGLLSMANSGVNSNGSQFFITCAKCEWLDNKHVVFGRVLgDGMLAVRKIENVatgp--nnr 191 Japanese rice
1MZW_A     88 ASIYRGPFADENFKLRHsAPGLLSMANSGPSTNGCQFFITCSKCDWLDGKHVVFGKII-DGLLVMRKIENVptgp--nnk 164 human
AAP21373  109 MSIYGHKFEDENFTAKHtGPGLLSMANSGPNTNGCQFFITCAKCDWLDNKHVVFGRVLgDGLLVMRKIENVaigp--nnr 186 thale cress
NP_610224  94 TSIYGNTFGDENFTLKHdSPGLLSMANSGKETNGCQFFITCAKCNFLDGKHVVFGRVL-DGLLIMRKIENVptgp--nnk 170 fruit fly
B53522    258 ESIYGEKFADENFSYKHsEPFLLSMANAGPNTNGSQFFITTVPCPWLDGKHVVFGKVV-AGQEVVKMMEAEgrs---ngq 333 Toxoplasma gondii
EAL18455   90 FSIYGAQFEDENFKVKHtGPGLLSMANSGPNTNGCQFFITTAPAEFLDGKHCVFGRVI-DGLLTVRKIENVptga--nnr 166 Cryptococcus neofo...
1QNG_A     82 ESIYGRSFTDENFNMKHdQPGLLSMANAGPNTNSSQFFITLVPCPWLDGKHVVFGKVI-EGMNVVREMEKEgak---sgy 157 malaria parasite P...
1AK4_A     76 KSIYGEKFEDENFILKHtGPGILSMANAGPNTNGSQFFICTAKTEWLDGKHVVFGKVK-EGMNIVEAMERFgsr---ngk 151 human
CAE76450   91 CIYGTKSFADENFLLKHdTPGLLSMANAGPNTNGSQFFITTVPTPFLDGKHVVFGKVV-DGMDVVKKMENTktgyrgkdv 169 Neurospora crassa

Feature 1                
1M63_C    152 TSKKITIADCG 162 human
AAP73848  192 PKLACVISECG 202 Japanese rice
1MZW_A    165 PKLPVVISQCG 175 human
AAP21373  187 PKLAVVITECG 197 thale cress
NP_610224 171 PKLPVTISQCG 181 fruit fly
B53522    334 PKCAVEISSCG 344 Toxoplasma gondii
EAL18455  167 PKLQVRIAECG 177 Cryptococcus neoformans var. neoformans B-3501A
1QNG_A    158 VKRSVVITDCG 168 malaria parasite P. falciparum
1AK4_A    152 TSKKITIADCG 162 human
CAE76450  170 PNLDVVIAQCG 180 Neurospora crassa

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