Conserved Protein Domain Family
arom_aa_hydroxylase

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cl01244: arom_aa_hydroxylase Superfamily 
Biopterin-dependent aromatic amino acid hydroxylase; a family of non-heme, iron(II)-dependent enzymes that includes prokaryotic and eukaryotic phenylalanine-4-hydroxylase (PheOH), eukaryotic tyrosine hydroxylase (TyrOH) and eukaryotic tryptophan hydroxylase (TrpOH). PheOH converts L-phenylalanine to L-tyrosine, an important step in phenylalanine catabolism and neurotransmitter biosynthesis, and is linked to a severe variant of phenylketonuria in humans. TyrOH and TrpOH are involved in the biosynthesis of catecholamine and serotonin, respectively. The eukaryotic enzymes are all homotetramers.
Statistics
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Accession: cl01244
PSSM Id: 470129
Name: arom_aa_hydroxylase
Created: 8-Feb-2008
Updated: 4-Oct-2023
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