Conserved Protein Domain Family
tankyrase_like
?
cd01438: tankyrase_like 
Tankyrases interact with the telomere reverse transcriptase complex (TERT). Tankyrase 1 poly-ADP-ribosylates Telomere Repeat Binding Factor 1 (TRF1) while Tankyrase 2 can poly-ADP-ribosylate itself or TRF1. The tankyrases also contain multiple ankyrin repeats that mediate protein-protein interaction (binding TRF1 and insulin-responsive aminopeptidase) and may function as a complex. Overexpression of Tank1 promotes increased telomere length when overexpressed, while overexpressed Tank2 has been shown to promote PARP cleavage- independent cell death (necrosis).
Links
?
Statistics
?
PSSM-Id: 238718
Aligned: 5 rows
Threshold Bit Score: 375.007
Created: 10-Jan-2006
Updated: 2-Oct-2020
Structure
?
Aligned Rows:
Download Cn3D
PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
O95271    1091 QGTNPYLTFHCVNQGTi----------LLDLAPEDK--EYQSVEEemqstiREHRDGGNAGGIFn---RYNVIRI--QKV 1153 human
CAG12585   976 QGANPYLTFHCASQGTi----------LIDLAPDDK--EYQSVEEemqstiREHRDGGNAGGVFs---RYNIIKI--QKV 1038 Tetraodon nigrov...
NP_651410  948 QLRSTTGIGNNVNLCTl----------LVDLLPDDK--EFVAVEEemqatiREHRDNGQAGGYFt---RYNIIRV--QKV 1010 fruit fly
NP_989671 1030 QGTNPYLTFHCVSQGTi----------LLDLAPDDK--EYQSVEEemqstiREHRDGGNAGGIFn---RYNVIRI--QKV 1092 chicken
CAG04910   800 RLRPPAQADQGHREAAgrtarwkpvpdLPLLRPGNRpdRPGSRRQ------GVPVCGGGAAEHHprapRWRERRRslQPL 873  Tetraodon nigrov...

O95271    1154 VNKKLRERFCHR-QKEVSEENHNHHNERMLFHGSPFINAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGT 1232 human
CAG12585  1039 VNKKLRERYTHR-QKEIADENHNHHNERMLFHGSPFINAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGT 1117 Tetraodon nigrov...
NP_651410 1011 QNRKLWERYAHR-RQEIAEENFLQSNERMLFHGSPFINAIVQRGFDERHAYIGGMFGAGIYFAEHSSKSNQYVYGIGGGI 1089 fruit fly
NP_989671 1093 VNKKLRERFCHR-QKEVSEENHNHHNERMLFHGSPFINAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGT 1171 chicken
CAG04910   874 QHHQGVKAGCFRaADRDEPALTKVCFLLADSEGSPFINAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGT 953  Tetraodon nigrov...

O95271    1233 GCPTHKDRSCYIC------------HRQMLFCRVTLGKSFLQFSTMKMAHAPPGHHSVIGRPSVNGLAYAEYVIYRGEQA 1300 human
CAG12585  1118 GCPTHKDRSCYLC------------HRQMLFCRVTLGKSFLQFSAMKMAHAPPGHHSVIGRPSVNGLAYAEYVIYRGEQA 1185 Tetraodon nigrov...
NP_651410 1090 GCPSHKDKSCYVC------------PRQLLLCRVALGKSFLQYSAMKMAHAPPGHHSVVGRPSAGGLHFAEYVVYRGEQS 1157 fruit fly
NP_989671 1172 GCPTHKDRSCYIC------------HRQMLFCRVTLGKSFLQFSTMKMAHAPPGHHSVIGRPSVNGLAYAEYVIYRGEQA 1239 chicken
CAG04910   954 GCPAHKDRSCYVChrsadvnggclcARQMLFCRVTLGKSFLQFSAMKMAHAPPGHHSVIGRPSVNGLAYAEYVIYRGEQA 1033 Tetraodon nigrov...

O95271    1301 YPEYLITYQIMKP 1313 human
CAG12585  1186 YPEYLITYQILKP 1198 Tetraodon nigroviridis
NP_651410 1158 YPEYLITYQIVKP 1170 fruit fly
NP_989671 1240 YPEYLITYQIVKP 1252 chicken
CAG04910  1034 YPEYLITYQIVKP 1046 Tetraodon nigroviridis
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap