1K1D,1GKP,1NFG,1KCX


Conserved Protein Domain Family
D-HYD

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cd01314: D-HYD 
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D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine or hydantoin. The hydrolysis of dihydropyrimidines is the second step of reductive catabolism of pyrimidines in human. The hydrolysis of 5-substituted hydantoins in microorganisms leads to enantiomerically pure N-carbamyl amino acids, which are used for the production of antibiotics, peptide hormones, pyrethroids, and pesticides. HYDs are classified depending on their stereoselectivity. This family also includes collapsin response regulators (CRMPs), cytosolic proteins involved in neuronal differentiation and axonal guidance which have strong homology to DHPases, but lack most of the active site residues.
Statistics
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PSSM-Id: 238639
Aligned: 29 rows
Threshold Bit Score: 527.171
Created: 6-Mar-2002
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
active sitetetramer
Conserved site includes 6 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:1K1D; Geobacillus stearothermophilus D-Hydantoinase

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                        # #            
1K1D_A        3 KIIKNGTIVTA--------TDTYEAHLLIKDGKIAMIGQNLEekg--aeVIDAKGCYVFPGGIDPHTHLDmplgg----t 68  Geobacillus stea...
NP_769973     8 LIIRGGRVATT--------TDVFEADVAISGETIAAVGRGLPaa---krEIDARGKLVLPGGVDSHAHIEqlsaa---gi 73  Bradyrhizobium j...
AAF69237      6 LIIKNGIICTA--------SDIYAAEIAVNNGKVQLIAASIDpsl-gseVIDAEGAFITPGGIDAHVHVDeplkl---lg 73  Saccharomyces kl...
ZP_00098583   4 LIIKNGTVVSP--------SSSTICDVAIKDDKIVGLGFYEAaeg--irTIDATGKYVMPGVIEAHMHCMapfqg----c 69  Desulfitobacteri...
NP_376926     1 MIFKNARVITP--------KGIIETDFEVEEGKIKKIKKDIVg-----eGKDLSGYYVLPSVIDGHTHFNsrylgakeii 67  Sulfolobus tokodaii
ZP_00005215   5 TVIHGGTIVTP--------TESWQGDLGLVGGRIAGLAERLPgg---arRIDATGRLVLPGGIEAHAHIAqesss---gl 70  Rhodobacter spha...
NP_377042     5 LILKNVKAFTV--------SGPFEGDIAIKDGKIAKIGGDIQeqa--nkVIDLTGKYVVPGLIDGHTHMEfpfmk----e 70  Sulfolobus tokodaii
EAA67040      6 LIITNATIVQPlslpatasDILPNTDIAISGGKIYLLGQNLSslfptapTLSADGAYVLPGGVDSHVHLQqdns------ 79  Aspergillus nidu...
ZP_00028774  73 TVVRNARVVTA--------ADTFTSDIGIRDGRIVALGLTLDag---vrEIDAAGRHVTPGGVDSHVHFDqptgd---gs 138 Burkholderia fun...
NP_769935    23 LAIRGGTIVTA--------SDEFRADIGIRDGRIVSIADHLEga---arEIDATGLLALPGGIDSHVHISqasgp---dv 88  Bradyrhizobium j...
Feature 1                                                                                       
1K1D_A       69 vtkDDFESGTIAAAFGGTTTIIDFCLtnk----gepLKKAIETWHNKAngk-avIDYGFHLMISEitd-dvLEELPKVle 142 Geobacillus stea...
NP_769973    74 mnaDTFESATVSAAFGGTTTVIPFAAqhv----gmkLPQVVEDYHALAkkg-avIDYAFHMIIADatretvEEHIPALvk 148 Bradyrhizobium j...
AAF69237     74 dvvDTMEHATRSAVAGGTTTVVAFSTqdvskkgpsaLAESVKLDVDEYseqtlyCDYGLHLILFQie--kpSVEARELld 151 Saccharomyces kl...
ZP_00098583  70 lgaNTFYQQSVSGAFGGVTMFMDFANvfp----gksVLEAVKERRAEMee--saIDFSVHGKFVKspp-elVEEIPQLae 142 Desulfitobacteri...
NP_376926    68 ptaDDYKSGSEITLAGGITSIINFIDpln-----reVTEAVKDEIEKAkst-agIDYSFHLIIKRkd---qINYLPEIik 138 Sulfolobus tokodaii
ZP_00005215  71 msaDDYYTGSVSAAFGGNSSFIPFAAqhr----gqsVDAVIETYDSRAapn-svLDYSYHLIISDptetvlTEELPRAfa 145 Rhodobacter spha...
NP_377042    71 vtaDDFYYGTRAAVAGGVTTIVDFITpak----gqdLLSAYEQWRSNAdpk-viSDYGLHMIIREsnt-kiLEQIPEIin 144 Sulfolobus tokodaii
EAA67040     80 ptgDTWETGTRSAIAGGTTTVLAFASqkrt---dgsLFPVVEEYHRRAsgn-afCDYGFHLILSNptekilAEELPVLvk 155 Aspergillus nidu...
ZP_00028774 139 imaDDFLSGTTSAACGGTTTVIPFACqqr----ghtLREAIDDYHRRAggk-plIDYAFHLIITDptpqvlKEELPTLia 213 Burkholderia fun...
NP_769935    89 vmaDDFASATRAAAAGGNTMVLPFALqek----gtsLRTCVENYRKLAege-cyIDTAFHLIISDptavvlGQELPALvk 163 Bradyrhizobium j...
Feature 1                      #                                 #                              
1K1D_A      143 --------eeGITSLXVFMAYKnvfq-addgTLYCTLLAAKELGALVMVHAENGDVIDYLTKKAladgNTDPIYHALTRP 213 Geobacillus stea...
NP_769973   149 ---------qGHASIKIFMTYDrlkv--ddePLLDILLAARQSGAMLCAHAENHGIIAWMVKRLlargYTLPKYHAVSHA 217 Bradyrhizobium j...
AAF69237    152 vqlqaayndyGVSSVKMFMTYPglqi--sdyDIMSAMYATRKNGFTTMLHAENGDMVKWMIEALeeqgLTDAYYHGVSRP 229 Saccharomyces kl...
ZP_00098583 143 ---------yGVPTFKMFMTYKkegvmideeTMLKVFEKAKEVGGLPMLHCEDNTMAEDAIEKVkkigDLSWVNFAKTKP 213 Desulfitobacteri...
NP_376926   139 ---------mGIKSIKMFMAYKgsmq-vddeTIYLVMKKAKELGVTVAIHAENGDVIEVLHNEYk--dKKDAIYHALTRP 206 Sulfolobus tokodaii
ZP_00005215 146 ---------rGITSFKVFMTYDlmnl--gdrGMLDILTVARRHGALTMVHAENNDMVKWMNARLaaagLTAPKYHAISRP 214 Rhodobacter spha...
NP_377042   145 ---------kGVVSFKLFMAYKnefm-lsdgELYKLIKRINDFGGVIGIHAENGEIINELIQQFvsegKIEPIYHYYSRP 214 Sulfolobus tokodaii
EAA67040    156 --------eeGISSVKLYMTYQpmrl--rdsELLDVMGTTRSLGMTTMIHAENADMIDWMTKRLesqgRTEPYAHALARP 225 Aspergillus nidu...
ZP_00028774 214 ---------eGYTSFKIYMTYDalkl--sdrEMLDTLSVARNEGAMVMVHAENADCIAWLTERLleagHTAPRYHATSRP 282 Burkholderia fun...
NP_769935   164 ---------dGYTSFKVFMTYDdlvl--sdkQLLEVFDVARREEALVMVHCEGYDAIRFLTTKLeregHIAPYYHGVSRP 232 Bradyrhizobium j...
Feature 1                                  #                                                    
1K1D_A      214 PELEGEATGRACQLTel--agSQLYVVHVTCAQAVEKIAEARNKGLDVWGETCPQYLVLDqsyle--------------- 276 Geobacillus stea...
NP_769973   218 RVSEAEAFTRLIGMAal--idQPIMIFHVSTAEGAKVIRDSRGQGLKVFAETCPQYLFLTaadld--------------- 280 Bradyrhizobium j...
AAF69237    230 SIVEGEATNRAITLAtt--mdTPILFVHVSSPQAAEVIKQAQTKGLKVYAETCPQYALLSdaitrchhhgevesygvgid 307 Saccharomyces kl...
ZP_00098583 214 QKCEAAAFERACRLAey--vdCPVMVVHTTHKEALDVARRAHESGFPIYVETGPHYLTLFddny---------------- 275 Desulfitobacteri...
NP_376926   207 VEVEEEAVNRASMLAyl--tgAKTYIVHISSPTSLDIISYWRKKGAKIFSETCPHYLLFDdsyy---------------- 268 Sulfolobus tokodaii
ZP_00005215 215 ALAEAEAINRAISLArl--vgAGLFIVHVSTPEGADLVARAQASGLPIHAETCPQYLAFTrddld--------------- 277 Rhodobacter spha...
NP_377042   215 DIMEIEATNRIASIAsmlgkdVKMYIVHTSTGEAVDIMSSYRKQGFKFYNETVPHYLTLNtdfl---------------- 278 Sulfolobus tokodaii
EAA67040    226 NIAEDEATYRALSLAel--adVPILIVHMSSSVAAKHVRRAQTKLLPVHAETCPHYLFFTseklk--------------- 288 Aspergillus nidu...
ZP_00028774 283 MLVEREATHRAIAFAel--idVPILIVHVSGREAVEQIRWAQSHGLKVYGETCPQYLFLTadslg--------------- 345 Burkholderia fun...
NP_769935   233 QAVEREATHRAISHAei--vgVPIMIVHVSGREAMEQVRWAQQRGLPVHAETCPQYITLTaddmkg-------------- 296 Bradyrhizobium j...
Feature 1                                                          #                            
1K1D_A      277 ------------kpnfEGAKYVWSPPLRek-whQEVLWNALKngqLQTLGSDQCSFDf--------------------kG 323 Geobacillus stea...
NP_769973   281 ------------kpgaDGAKWMCSPPPRth-adQEALWQALSlgdLQTISSDHAPYRfd-------------------eT 328 Bradyrhizobium j...
AAF69237    308 lssisespftnpddrfIGSKYICSPPIRpe-gtQKSIWKGMNngtFTIVGSDHCSYNyyek---------------tstA 371 Saccharomyces kl...
ZP_00098583 276 -------------ekeEGYLYLCSPPLRtp-qdAEDLWQGLQdgtISVTGSDDCTFDtnekaa----------flekdeN 331 Desulfitobacteri...
NP_376926   269 -------------lrsDGNRFIMSPPLRrk-elREELVRKLHm--VNTLGSDYSGFMs---------------------V 311 Sulfolobus tokodaii
ZP_00005215 278 ------------rpgmEGAKYICSPPLRda-atQAALWNHARrgtFESVSSDHAPYRf--------------------dA 324 Rhodobacter spha...
NP_377042   279 -------------krpDGYRYVMSPPLRsd-eqRTKLWMRLAsgdIFTVGSDHCVYSd---------------------A 323 Sulfolobus tokodaii
EAA67040    289 ------------gedfRGAMCVCSPALRespmdLKAMWDGLVngtFTTFSSDHAPSKyiflpsllhqlptvaptrfdhqL 356 Aspergillus nidu...
ZP_00028774 346 -----------cddsfEGAKCICSPPPRdk-anQQVIWDGLEngtFEVFSSDHAPFRyd------------------gpD 395 Burkholderia fun...
NP_769935   297 -----------lnmdiTGAKYVCSPPPRda-esQQAIWEGITsgvFQTFSSDHCPFRyd------------------dpK 346 Bradyrhizobium j...
Feature 1                                                                                       
1K1D_A      324 QKELGr-------gDFTKIPNGGPIIEDRVSILFSEGVKkGRIT-LNQFVDIVSTRIAKLFglFPKKGTIv-vGSDADLV 394 Geobacillus stea...
NP_769973   329 GKLRAgp-----npNFKQVANGLPGLELRLPLLFDAMVSkGRLG-LEKFVELTATAPAKIYnlHPRKGSIv-vGADADIA 401 Bradyrhizobium j...
AAF69237    372 SKHRAfdpennkngEFRYIPNGLPGVCTRMPLLYDYGYLrGNLTsMMKLVEIQCTNPAKVYgmYPQKGSIlpgVSDADLV 451 Saccharomyces kl...
ZP_00098583 332 GKYIQ---------DFTKVVNGMSGLEVRLPILLSEGAGkGRLT-INQVCALTSTNVAKIYgcYPQKGIIa-pGSDADLV 400 Desulfitobacteri...
NP_376926   312 YKDKAl--------SYIEVPNGVSSTEFLVPTIMSFLFD-NLIT-PEKVAEITSYNQIKLYn-LKEKGFDe--GKDADFT 378 Sulfolobus tokodaii
ZP_00005215 325 SGKFAnga----epAYPAIANGLPGIAMRLPYLFSEGVAaGRIS-LQQFAALSSSNAARLFg-MERKGALl-pGYDADIA 397 Rhodobacter spha...
NP_377042   324 QKKRYree----vpPFHEIPNGVPGTETILPILFYYGVKkGIIG-MERFIEVTSYNPARLFglYPRKGTIm-pGSDADFA 397 Sulfolobus tokodaii
EAA67040    357 GKKKGt-------sSFTQIPNGLPGLETRMPSLFCAGVLtGRLS-VQKFVELTASNPAKLYglSDRKGTIa-pGYDADLV 427 Aspergillus nidu...
ZP_00028774 396 GKRVHgd-----nvSFDKISNGIPGVETRMALLWSEGVRtGRIT-AQSFVALTSTNAAKLYglYPRKGSIa-iGADADLV 468 Burkholderia fun...
NP_769935   347 GKLTPns-----rtSFRWVPNGIPGVETRLPILFSEGVSkGRIS-LQKFVELTATNHARIYglYPRKGSIg-vGFDADIV 419 Bradyrhizobium j...
Feature 1                                                                                  
1K1D_A      395 IFDPNIERVISAethh-----------------mavDYNAFEGMKVTGEPVSVLCRGEFVVRd--KQFVGKPGYG 450 Geobacillus stearothe...
NP_769973   402 IWDPNRETVIADemmh-----------------dlaGYTPFAGRKVKGWPVSVLSRGRVIVEg--NKCLASAGSG 457 Bradyrhizobium japoni...
AAF69237    452 IWYPDDSKKEYNskpklitn---------klmehncDYTPFEGIEIKNWPRYTIVKGKIVYKe--GEILKENADG 515 Saccharomyces kluyveri
ZP_00098583 401 IVDMAQEVTLSKdilh-----------------nniSYCLHEGFKVKGYPIMTIARGKVIVEn--GEFRGEKGAG 456 Desulfitobacterium ha...
NP_376926   379 VIKREEWIVKDWhg--------------------kmDYSIYEGVKFKAKVIQTYLRGELTFD---EDYKGSRGKL 430 Sulfolobus tokodaii
ZP_00005215 398 IWNPEETREVSLadqh-----------------damDYTPFEGMRLTGWPEHVLSRGETVVEa--GELKAARGRG 453 Rhodobacter sphaeroides
NP_377042   398 VIDPNRKVRISAdvlh-----------------sniNYTIYEGMEVEGWNIMTIRRGEIVYEe--GQVIGKKGSG 453 Sulfolobus tokodaii
EAA67040    428 IWYPTAEQAEAMqagsssrvtmksfqlknemlhhdiDYTPFEGMEFTNWPRYTILRGKLVWDrdgGGVIGGKGDG 502 Aspergillus nidulans ...
ZP_00028774 469 IWNEGGEYPVENtrlh-----------------hnvDYTPYEGMRLTAWPAITLSRGDIVWDg--DRPCGETGRG 524 Burkholderia fungorum
NP_769935   420 LWDPKLKKPIQQadlh-----------------hgaDYTPWEGFDVTGWPVTTVARGRVVYEh--GRIVGDKGAG 475 Bradyrhizobium japoni...

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