2JC6


Conserved Protein Domain Family
STKc_CaMKI_delta

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cd14168: STKc_CaMKI_delta 
Click on image for an interactive view with Cn3D
Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I delta
STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CaMKs are multifunctional calcium and calmodulin (CaM) stimulated STKs involved in cell cycle regulation. The CaMK family includes CaMKI, CaMKII, CaMKIV, and CaMK kinase (CaMKK). In vertebrates, there are four CaMKI proteins encoded by different genes (alpha, beta, gamma, and delta), each producing at least one variant. CaMKs contain an N-terminal catalytic domain and a C-terminal regulatory domain that harbors a CaM binding site. CaMKI proteins are monomeric and they play pivotal roles in the nervous system, including long-term potentiation, dendritic arborization, neurite outgrowth, and the formation of spines, synapses, and axons. In addition, they may be involved in osteoclast differentiation and bone resorption. The CaMKI-delta subfamily is part of a larger superfamily that includes the catalytic domains of other protein kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.
Statistics
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PSSM-Id: 271070
Aligned: 4 rows
Threshold Bit Score: 593.177
Created: 16-Oct-2012
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 18 residues -Click on image for an interactive view with Cn3D
Feature 1:ATP binding site [chemical binding site]
Evidence:
  • Structure:2JC6: Human CaMKI-delta binds GSK-3 inhibitor Xiii; contacts at 4A.
  • Comment:also based on structures of other members of the CAMK family bound with ATP or ATP analogs or inhibitors
  • Citation:PMID 9362479

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                         ####    #            # #                             #         
2JC6_A        13 WKKQAEDIKKIFEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKgKESSIENEIAVLRKIKHENIVALEDIYESP 92  human
XP_003640379  12 WKKQAEDIKKIFEFKETLGTGAFSEVVLAEERASGKLFAVKCIPKKALKgKESSIENEIAVLRKIKHENIVALEDIYESP 91  chicken
NP_001116532  14 WKKQVDNIKEIFEFKEVLGTGAFSEVVLAEERSTGKMYAVKCIPKKALKgKESSIENEIAVLRKIKHENIVALEDIYESS 93  zebrafish
NP_001086095  13 WKKQVEDIKRMFQFKEVLGTGAFSEVVLAEEKETGKLFAVKCIPKKALKgKESSIENEIAVLRKIKHENIVALEDIYESP 92  African clawed ...
Feature 1              ####   #                                          ## #            ##      
2JC6_A        93 nHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAVYYLHRMGIVHRDLKPENLLYYSqDEESKIMISDFGLSKM 172 human
XP_003640379  92 nHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAVYYLHRMGIVHRDLKPENLLYYSqDEESKIMISDFGLSKM 171 chicken
NP_001116532  94 dHLYLIMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAVNYLHTMGIVHRDLKPENLLYFNpQDGSKIMISDFGLSKM 173 zebrafish
NP_001086095  93 sHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAVSYLHRLGIVHRDLKPENLLYFSqVEESKIMISDFGLSKM 172 African clawed ...
Feature 1                                                                                        
2JC6_A       173 EGKGDVMSTACGTPGYVAPEVLAQkPYSKAVDCWSIGVIAYILLCGYPPFYDEnDSKLFEQILKAEYEFDSPYWDDISDS 252 human
XP_003640379 172 EGKGDVMSTACGTPGYVAPEVLAQkPYSKAVDCWSIGVIAYILLCGYPPFYDEnDSKLFEQILKAEYEFDSPYWDDISES 251 chicken
NP_001116532 174 EGTGDVMSTACGTPGYVAPEVLAQkPYSKAVDCWSIGVIAYILLCGYPPFYDEnDSKLFEQILKADYEFDAPYWDDISDS 253 zebrafish
NP_001086095 173 EGKGDVMSTACGTPGYVAPEVLAQkPYSKAVDCWSIGVIAYILLCGYPPFYDEnDSRLFEQILKADYEFDSPYWDDISES 252 African clawed ...
Feature 1                                                                     
2JC6_A       253 AKDFIRNLMEKDPNKRYTCEQAARHPWIAgDTALNKNIHESVSAQIRKNFAKSKWRQAFNA 313 human
XP_003640379 252 AKDFIRNLMEKDPNKRYTCEQAARHPWIAgDTALNKNIHESVSAQIRKNFAKSKWRQAFNA 312 chicken
NP_001116532 254 AKDFISCLMEKDPSKRNTCEQALRHPWIAgDTALCKNIHESVSRQMRKNFAKSKWRQAFNA 314 zebrafish
NP_001086095 253 AKDFIQNLMEKDPNKRYTCEQALRHPWIAgDTALCKNIHESVSAQIRKNFAKSKWRQAFNA 313 African clawed frog

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