Q5RD58        41 SHLHGRLMLLHSLPC--FIEKD--LKEA-LTQFIEEESLSDYDRDA----EASLEAVKSGEVDL-HQLASTWAKAYAETT 110 Sumatran orangutan
1_pfamImport   1 KELVARVMNYHDIPC--FVETG--LNNK-LKNFVDNERQNLHDDQA----ALLLQKIRDDPTLI-DHVADVVAEKYKNTW 70 
AAI25951      41 SDLHGRIMLLHRIPC--FVETD--LKNR-LGSFIESETLADYDRDA----EAALQKLTSGEVDI-NKLTNLWAKAYSETT 110
XP_002608482  35 RDLRGRLVAAHNLPC--YVEDD--LLRQ-LEEFIAVETSKLQDESA----ESSLKALDTGGKSA-GDKAESWAHAFTREC 104
XP_011445727  35 SDLVGRLVNAHNLPC--YVEED--LKNK-LEKFMTEETNKLFDENS----QKALQRLKNGDINI-DDVVTKWHNAFSEEV 104
EEC12362      42 keivFRLMQEEQLPC--YVEDD--LTTS-LSDFIAHETEQFFDQTS----STAIEKFQRDG-DV-EALTARWTRDFREAS 110
XP_002118317  15 NELAHRLITAHNLPC--YLLGK--LQAS-LKEFVSSTLCQLQVDKA----EQSIHHLKQFGPDViKDISDHWCKCLQDEV 85 
XP_008183385  43 DELSHRIINGFNLPL--NVIEE--LSSE-LQKFVEKCTIDFYDCQT----VDAIESIRNESIEV-EDIVKYWEKAFQEET 112
XP_008200044  30 GELVHVLILKNNLPI--YVEKD--LAEN-LSQFVNDWSIKHNNEHT----ASLIDDARNDKTNI-DEITKEWEKLMREEM 99 
Q7QB80        38 AELSHQIVAVRMDPImkFLKADreLLPT-LQAFVERENQSFYDERD----ELLLDKFRHGSPDV-DGLALDTEKLYREEI 111 Anopheles gambi...
EEB17831      41 REFTYRILYNNKIPH--YLFDD--VYSQ-LEKFVETETLRYYDEVA----EEKLKEFKNDDFDV-DSVVKYWEKLFKNET 110
Q54R54       250 lektkddldeiesfnsqqqQQQ--QQQQ-QQQTPQKQQPPPPQQTP----QQSQQSQPQSSGGIiDSIGQNLDKGVA--- 319 Dictyostelium d...
NP_001256329  49 EDWVGKLRAQ---PSgkFLDYE--GAKEaLRKFIYSETINHQNRRTisniECAVKKKREMGMPL-------FQPSRNRRL 116 Caenorhabditis ...

Q5RD58       111 LEHARPEEp---------SWDEDFADVYHDLIHS-PASETLLNLEHNYFVSISELIGERDVELKKLRE----------RQ 170 Sumatran orangutan
1_pfamImport  71 QEYAPPIS----------TQPNNFPLSYHYLIHS-PAMQILMQLEKKYHSAVAKLLSDKEQSLTKMCE----------RH 129
AAI25951     111 LEHARPEEa---------SWDEDFASVYHELIHS-PASETLLNLEHNYFVSVSELISERDMELKKLQE----------RQ 170
XP_002608482 105 TRYSDPEAa---------NKDHQFAMMYHALIHS-SALETLLNLEHTYAVANGDVINHRENARKNLED----------KQ 164
XP_011445727 105 KRYAKPESv---------TEQQVFSEVYHSLIHS-PALDTLLNLEHTYALTIEDLIQQRDKDLEYLDD----------RQ 164
EEC12362     111 LAEEE-------------TPDSRFPHMYHTLIHS-PALDTVLNLEHTYAVAVGDMVRERDETLGRLQK----------RQ 166
XP_002118317  86 AHWSDHSNkrnavqsiqlDNGQSVAQVYHALIHS-PAMEAILQLEYTYASVVKEIVKQRNTELEQFEI----------QH 154
XP_008183385 113 FSFTDNKGp---------SNDQLFGTAFHKLAHSgPSLDAILHIEYGYAQAVQDIMSRKCRQVTSLTK----------TQ 173
XP_008200044 100 AEYGERRCa---------SDEELFATAYHKMVHS-PALETMLQLEHMYSKTVRAKTEEKNRCIQNLSM----------KQ 159
Q7QB80       112 LEFADRVGp---------TDEEIFAQSYHQLVHS-SLLPEILAKEREYARTIASLTTQMTQQITTMNT----------LH 171 Anopheles gambi...
EEB17831     111 VEYCEPTGt---------TDEELFSMVYHKLVHS-GALESILKKEQMYGATATSLAHKRKKEIKELSEkqvfiyvkinKQ 180
Q54R54       320 ------------------RASSFFSFGFNKKNNQtPPINSPPSTPQLSSDDPNNVNNNSNNNNNNNNNn---------NN 372 Dictyostelium d...
NP_001256329 117 LEPRRKPVv---------PFEEKFTYVVEQ--SSsENLLTLMRMEVFMKKQMTDMIRARNWEVDQLS-----------KQ 174 Caenorhabditis ...

Q5RD58       171 GIEMEKVMQEL-------GKSLTDQDVNSLAAQHFESQQD------------LENKWSNELKQSTAIQKQEYQEWVIKLH 231 Sumatran orangutan
1_pfamImport 130 RGEMSRACDHV-------GFEYTTEDVSILATKQLADTDR------------MQKHWEDNYRRLTEEQKQEYCDLVIRLA 190
AAI25951     171 AVEMNKVMQEL-------GKTLCDQDVNTVAAQHFEAQQV------------LESKWASELKQVTGIQKQEYQEWVMKLH 231
XP_002608482 165 HQEMESAMQGL-------GVTHTDEQVNTLAQKHFDSTQAswyqylfvvvqkLEVQWDHEVCNLQKTQRDEYREWVKQVH 237
XP_011445727 165 REEMEDAMKNA-------GTKYTDAQVNQLAQRHIDNSQL------------ISGKWSSELSNLRDTQKREFREWVLKVH 225
EEC12362     167 TSEMERCVQQV-------GLTLTDRDINDIAARHFEETQAs----------rLMDQWDKRIGSLKQTQRKEFWEWVRTVH 229
XP_002118317 155 QQQLEIAIQ---------SGIASDRKVSRLAAQHMEELQF------------KNAKWNSTLSDLMENQKREFYAWMVRVY 213
XP_008183385 174 TEEMNYAMDGL-------NKYTTEDDINALALKHFDDQTL------------LQGKWNSRLDTLKQEQRTGYREWVMKTV 234
XP_008200044 160 TEEMNHAVDRL-------EQDMTESKINELVARHYEAHSL------------LKVKLTSELDTIKEAQRREYREWLMQML 220
Q7QB80       172 QEEIESKIKLL-------DISITPENINHMLAKQYGMQNM------------IRKQCESELESTRGHQKHEYRNWVTQHV 232 Anopheles gambi...
EEB17831     181 NDEMTVAMQDLhsmtiesEIRVSEKDINDLAAKHFEEQCL------------TSGRLNSEVEALHQSQRKEYRAWLMAMY 248
Q54R54       373 TQSKPIGINNNnnnnssnNRQRTDSQVSPPNSLNSSSPNKppqpttplnnnnSNNNNNNNNNNNNSIQRKS--------- 443 Dictyostelium d...
NP_001256329 175 CEKLVAETG---------DPDMHPHKISMLNEKLRQ----------------VHTTYSFQVADLSDTQKSKYRKAVDSLY 229 Caenorhabditis ...

Q5RD58       232 QDLK-----------NPNNS-SLSEEIKVQPSQFRESVEAIGRIYEEQRK----------------LEESFTIHLGAQLK 283 Sumatran orangutan
1_pfamImport 191 EEMK-----------QSDNKlNENGPVHNEVQRLLDHNRGRSLVSTRDPSedvesessvtvscgilMEESFTINLGAQLK 259
AAI25951     232 RDLQ-----------NPNNS-TINEEIKVQPGQLGEAGEAADRLFEEQRQ----------------LEESFTIHLGAQLK 283
XP_002608482 238 QDMKhsngnrttmyaSPNSV--------------------SNSVSKELPR----------------LEESFTIHLGAQMK 281
XP_011445727 226 EDTQ-----------SPSKStSYLNRVRALSSSLPEAEE--NERGPNTIR----------------MEESFTIHLGAQMK 276
EEC12362     230 EDYT-----------TSKGDrGFGARMRAASRSLAGHEVDNWTPPPPRPS------------------ESFTIHLGSQLK 280
XP_002118317 214 NSMVenngvptertlS-----MPHSIVATLSRAAPDSHLNHESNNHVDNR----------------MEESFTIYLGTQKK 272
XP_008183385 235 EEMQgvdglyspignSPINIvTNGFTISNM--SLYD------------------------------MEESFTIHLGSQMK 282
XP_008200044 221 EQNQ----------------------------ATSSLPTPNSPLTPHTPQpaiyssecarsidtpiLEESFTIHLGSQLK 272
Q7QB80       233 DESFlgq------seSPTQIgNRWSMISTQAPS---------------------------------MEESFTIHLGSQLK 273 Anopheles gambi...
EEB17831     249 ENEAl----------SPTLHlTSTSPKVLDNSSLDSGISSQPEPWPH-------------------FEESFTIHLGSQLK 299
Q54R54       444 ---------------------STGSSSTNLQPTLQRKQSGGAGNIPIINSgss-----------ssKFEDFTIGVGVQKK 491 Dictyostelium d...
NP_001256329 230 SRGS-------------------------IPAELLDDVILDEHAIPRPVAtttgg-------yadgVNESFTIYIGSQLK 277 Caenorhabditis ...

Q5RD58       284 TMHNLRLLRADML-DFCKH--KRNHRsg----vKLHRLQTALSLYSTSLCGLVLLVD-NRINSYSGIKRDFATVCQECTD 355 Sumatran orangutan
1_pfamImport 260 TMHNIRLVVADML-YFCRY--SDDGEm------EAQRFQTAMSLYSNSLSAIVLITD-KNLNECSGIEKEFRTVCESSTE 329
AAI25951     284 TMHNLRLVRSDVL-DFCKH--RRHSSsg----vKLRRLQTALSLYSTSLCGLVLLVD-NRVNSYSGIKRDFATVSQECTD 355
XP_002608482 282 TMHNIRLMRAHPL-DLCRH--KPNKIgg----tKPQRLQTALSLYSNTLCGLVLLVD-NRVNAYTGIKRDFSSACQQSTD 353
XP_011445727 277 TTHNLRLLCTDIL-DLCRH--KTHTVggm-vipQPQRLQTAMSLYSNDLCALIMMVD-NRLNSYTGLKRDFSKVCEQSTD 351
EEC12362     281 VMHNLRLLSANVL-DLCRHttyg------mgvpAPQRLQMAMSLHSNSLSGLVLLVD-NRINSYVGIKREFAAICHESTE 352
XP_002118317 273 TMHNIRLMIGHPL-DLCRS--AYTGSigsgigpPPQRIQTALSLYSSTLNGLILLVD-DKPNCYTGIKNEFAMICEESSE 348
XP_008183385 283 STHNIRIMSADTL-NLLSLtlEENGTvv----hHPQRLQTVLELYSQDLKGLVLFIDtNNLDFYSGLAKEFFDICDGSTE 357
XP_008200044 273 QMHNIRILSANVM-ELCAV--EDNDQss---epKPQLLQTALALYSSDLSGLVLMTD-NKIG--SRLTQDFQEICQRTTE 343
Q7QB80       274 HMHNIRILSTRVA-DLCSP--LYGDA-------SFGGPNVALGLYSSSLCGIVVLTPsGTITPDREIRRN----ANMSTE 339 Anopheles gambi...
EEB17831     300 QMHNVRILSANAL-DFCKIklPPEGVsh----vEPRRSETALSLYSSSLSGIVLLVDvGSFDGFAGLAKDFVDVCQQTTE 374
Q54R54       492 KIFNFKLIEESPL-QLCRPitslt-----gdykKSKRVDYIKTLYSDSLSAVILIID-PSLQFNTENEKKFIKYCNMSTE 564 Dictyostelium d...
NP_001256329 278 SMHNVCLVTVDRLtDLCQTleg--------dwtTSSRLEMATKLYSRNLSGTTLLVP-RDPMMHINSSSDFFKICEQSTD 348 Caenorhabditis ...

Q5RD58       356 FHFPRIEEQLEVVQQVVLYARTQRRSKlkesldsgnQNGGNDDKTKNAERNYLN-------VLPGEFYITRHSNLSEIHV 428 Sumatran orangutan
1_pfamImport 330 FHFETLQDQTTKVKEHALEASERRNRS---------LSSEETIEYKQNIDEMDGtg----tLNEGDFYITKHSNLSQVHL 396
AAI25951     356 FHFPRVDEQLEIVQQVVLYARAQRNSKqreq-pempRNGGNEDKNKILDRNSSN-------ILQGEFYITRHSNLSEVHI 427
XP_002608482 354 FHFPALQDQFSSIQEDLVRANSCRLARqaareeegnGSNGSADSEKSKSKSFSDln----rLQAGDFYITRHSNLAEVHV 429
XP_011445727 352 FHFPDLEQQFAIIEQELALANEHRQQH---------KHSEDADKVSLKSSSSTSseeknknLRSGDFYLTKHSNLSEVHV 422
EEC12362     353 LHFADIDDQLETVRAKAREVAEIRTAAs--------LSGSDGSSSQSSRRSSFSgq----dHSPGDFYVTRHSNLSEAHV 420
XP_002118317 349 FHFLSHPEQLHHIRRSIQKSQSTRAKRq-------dSEDNDIDSLEIFWDEDDDsv----vLALGDFYSTHHSNLSDIHV 417
XP_008183385 358 FHFNSLQDQLEIIKSDLKVAVENRKCK---------GPVSNFLSPELQARRNKSk-----lLQCGDVYITKHSNLASVHL 423
XP_008200044 344 FHFPHIDDQLDKISNTAQLYLKSQKEN---------------------SNRNINse----lLQAGDFYITRHSNLAQVHV 398
Q7QB80       340 FHFEQIDRQIEKIQEDLRNLQHGHAVE---------AGGAQSLAAAAGRRPDRTvv----tVKPGDAFITRHSNLSHSHV 406 Anopheles gambi...
EEB17831     375 FHFNNIESQLEAIKIQVKDAVQWRSEK------------AKNSSGYQNSKMSSGgk----sLQAGDLYITKHSNLSQVHV 438
Q54R54       565 LHFDSIDSQIHTFKQSLLKEEEREKEE---------------------NNNNNNni----kLSNGDFFITKHSNLSDVQV 619 Dictyostelium d...
NP_001256329 349 LHFDSLAEQLKKTLAANRERNSWKADKideetskliAEGKTPPEQLVPSSALRQdp----tCTVGDVYITRHSNLHKVQI 424 Caenorhabditis ...

Q5RD58       429 AFHLCVDD----HVKS-GNITARDPAIMGLRNILKVCCTHDITTISIPLLLVH-DMSEEMTIPWCLRRAELVFKCVKGFM 502 Sumatran orangutan
1_pfamImport 397 VFHLVAEEnqlrTKASlTTVTSRHSVILGLRHILKVASSHDIRHITIPLLLSH-ELTEEITFQWCVKRAELVMKCIKGFM 475
AAI25951     428 VFHLCVDD----NVRS-GNITARDPAIMGLRNILKVCCTHDITTITIPLLLVH-DMSEEMTIPWCLKRAELVFKCVKGFM 501
XP_002608482 430 VFHLVADD----SLRS-TNINARNPTILGLRSILKVACRHDILTLTVPLLLVH-EMGEEMTVQWCLKRAELIFKCIKGFM 503
XP_011445727 423 VFHLVADD----SIKQ-SDISSRHPVILSIRNIIKLCFRYDINTITIPLLLFN-EMTEEMTIPWCQKRVELMFKCVKGFM 496
EEC12362     421 VFHVVGDE----SLRG-ADVGSRHPVILGLRNVLRVAHERDVCGVTLPLLLSH-ELYEEMTIPWCLRRAELVFKCIKGFM 494
XP_002118317 418 VYHLVVND----DVKS-DRLPNRHPILTGLRNALNTAASNDVTTITIPLLLVN-EMTEEMTISWCVKRAELIFKCVKGFM 491
XP_008183385 424 VFHMVIDD----SLKS-GDINSRHPVILGLRNILKTACSYDITMITIPLFLTH-EMTEDMTVPWCQKRAELVLKCVKGFM 497
XP_008200044 399 IFHMVSDD----SLRG-SDINSRHPVVLGLRNILKTACSNDITSLTIPLLLQY-EMTEEMTISWCEKRAELVFKCVKGFM 472
Q7QB80       407 IFHLISDE----TFQSpSEINSRHPVILGLRNILKIASRHDITTLTIPALLRH-EMSEDMTVSWCIRRAELVFKCAKGFM 481 Anopheles gambi...
EEB17831     439 VFHLLVDD----SVKN-SDVNSRHPVILGLRNILKTAASYDITTITLPLLLTN-EMSEGMTVAWCSKRAELVFKCVKGFM 512
Q54R54       620 VFHLVIDSknrtPLGGdNQLSTTSDIAKGLRNILLTASKYGIGNITIPICLTEsELDLNVTNSNLLSRCVSVLSVTRASL 699 Dictyostelium d...
NP_001256329 425 VYHLVVDE----TLQS-LEINSRHPCLAGVRNIIRTAARYNTSTIHIPLLLID-RPDESTTIAWCLKRAEMLFKCVKGYL 498 Caenorhabditis ...

Q5RD58       503 MEMASWDGGISRT-----VQFLVPQSISEE--MFYQLSNMLPQIFRVSSTL 546 Sumatran orangutan
1_pfamImport 476 MEMATWDGGISRT-----IQFVIPPGVSEE--AFDRLRYTLPEVFRTTSTR 519
AAI25951     502 MEMASWDGGISRT-----VQFLVPQSISEE--MFYQLSNMLPQIFRVSSTL 545
XP_002608482 504 MEMASWGGTESRT-----IQFMVPEGISDE--MFHQFSNMLPQIFRVSTPL 547
XP_011445727 497 MEMAAYGGYKSRT-----IQFLVPPGISED--VFSGISSMLTNIFRLSNPL 540
EEC12362     495 IEMASLVGEETRT-----VQFLVPQGISED--LFASLSAMLSSIFRVSNPL 538
XP_002118317 492 MENEMWSNNQACI-----VQFLIPKGISEE--MFNTFTGMLPGIFRMAAAL 535
XP_008183385 498 IESVSLGGSELKT-----IQFLVPKGISEE--VFGILATMVPTIFRVSTPL 541
XP_008200044 473 IEMASWGGSELKN-----LQFMLPQGISSR--VFQSLTEMLPRIFKVSNPK 516
Q7QB80       482 IESASWGGAELNT-----LQLLLPHDISEE--LFRTLADMVPHVFRVANPK 525 Anopheles gambiae str. PEST
EEB17831     513 IEAAGVGGADIIN-----LQFLVPSGISAE--VFSTLATMLPTIFRVCNPL 556
Q54R54       700 TSLQEM--TSIKT-----VQFSLPSQLDSGntIFK---GPIAQKWKSAINP 740 Dictyostelium discoideum AX4
NP_001256329 499 MEVC--SGMDVESlphynVHFVLPSGLSPT--IYTAITNMFPSIFHLVPGV 545 Caenorhabditis elegans