2MXZ,2VO9


Conserved Protein Domain Family
L-Ala-D-Glu_peptidase_like
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cd14845: L-Ala-D-Glu_peptidase_like 
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L-Ala-D-Glu peptidase, also known as L-alanyl-D-glutamate endopeptidase
This L-Ala-D-Glu peptidase family includes L-alanyl-D-glutamate peptidase (bacteriophage T5) (also known as L-alanoyl-D-glutamate endopeptidase), and Ply118 and Ply500 L-Ala-D-Glu peptidase. Bacteriophage endolysin degrades the peptidoglycan of the bacterial host from within, leading to cell lysis and release of progeny virions. The bacteriophage endolysin Ply118 cleaves between L-Ala and D-Glu residues of Listeria cell wall peptidoglycan. This family belongs to the MEROPS peptidase M15 subfamily C.
Links
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Statistics
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PSSM-Id: 350620
Aligned: 66 rows
Threshold Bit Score: 69.6985
Created: 13-Jan-2014
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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active siteZn binding site
Conserved site includes 5 residues -Click on image for an interactive view with Cn3D
Feature 1: active site [active site], 5 residue positions
Conserved feature residue pattern:R H D [ED] HClick to see conserved feature residue pattern help
Evidence:
  • Comment:based on structures of Bacteriophage T5 L-alanoyl-d-glutamate peptidase, Enterococcus faecalis D,D-dipeptidase VanXYg, and Enterococcus faecium VanX, and on mutagenesis studies
  • Citation:PMID 9702193
  • Citation:PMID 9265630
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                     #                                  
2MXZ_A         9 SEKQLATVK----PELQKVARRALELSPy--------dFTIVQGIRt--vAQSAQNIANGTsf----------------- 57  Escherichia pha...
WP_020064836 181 NNKFLDTLYd--gTSERSMVKHISTKSIlgyk--vrvhDYVYEPLSn--vSVEVKLIAQTNqevenfldslkivsgyvwk 254 Brachyspira hyo...
WP_002950805 459 NYELLDKIYganeAEVKVNLTEVVWLKNhgsk---tfkFNSKNGAAaalqAVSNELDALALqkpellkfld-npsgtfnw 534 Campylobacter s...
WP_007922476  33 SGFNIDEVE----PLIIPQLKSIPGAAQgklkvhkrahAQLLKAFIl--iENYDLLHHVKTcagtlnlr------lrkpt 100 Pseudomonas sp....
WP_017696942   6 YTRNMDNINkl-aDNTKAAAKKLLAYAEknk-----igVLIYETIRt--eAQQRQNVNKGV------------------- 58  Bacillus subtilis
WP_005985971  89 AHQGQIVVD----RDLAADVAQIFELILes-------gFPVHTVLP----IAHAEIQAKAPfglspdtdn---ssgfafr 150 Desulfovibrio a...
WP_019999595  66 RHQGQVVIH----KGLEQDIKKIFNVILen-------rFPVESVIP----IAHPTIQKKGPyglssdtnn---tsayvwr 127 Desulfovibriona...
WP_017373442   9 SEKNLANIH----PDLIRVVRRCLEISRd--------dFCVIEGLRs--pERQKQLVREGL------------------- 55  Enterobacteriac...
WP_004641729   6 SQKSLSKLEgv-dPRLVKVIKRAIEVTEv--------dFTITEGLRt--kATQALYVKQGK------------------- 55  Acinetobacter h...
NP_353494      6 SQRSLARLDgv-hPDLVRVVRRAIQITEi--------dFVVTEGVRt--lEKQKDMVARGA------------------- 55  Agrobacterium f...

Feature 1                   #           #                                                        
2MXZ_A        58 -lKDP--SKSKHi-----TGDAIDFAPyingki------------------dwndleAFWAVKKAFEQAgkel------- 104 Escherichia pha...
WP_020064836 255 iiSKSa-SRSYHs-----YGVAFDTLPkknngkqiywawtrvnnkawyavpydkrwhPPKEVIKVFEKYg---------- 318 Brachyspira hyo...
WP_002950805 535 rvVEGtkRKSAHs-----YGIAIDINTdksdywrws-------------kdgryrnqIPEEIVRIFEKHg---------- 586 Campylobacter s...
WP_007922476 101 sgALSk-IPSNHa-----FGIAIDLNEedpg-----------------------ygdSVAPLAPIFQSLg---------- 141 Pseudomonas sp....
WP_017696942  59 --SQT--MKSYHl-----VGQALDFVPt----------------------------gGYSKSDTKWNGYgaadikkf-ia 100 Bacillus subtilis
WP_005985971 151 pqAGSa-KLSMHa-----RGWAVDLNPrlnpyikgeamlpp---rsaydpsmpgtltADHPVVLKFKELg---------- 211 Desulfovibrio a...
WP_019999595 128 piVKSh-KLSLHa-----LGLAIDINPrlnpyikgslvlpp---nasynplksgtlvSNSPVVQEFKRLg---------- 188 Desulfovibriona...
WP_017373442  56 --SQT--QNSRHl-----TGHAVDIAPvvh-------------------------gkIPWNHWQSFEVLadsmkks---a 98  Enterobacteriac...
WP_004641729  56 --SQT--MNSKHl-----EGLAVDLAAwvngtinwnfdyyf--kiadavrkasielgIKVKWGGAWRYLndydsskkayd 124 Acinetobacter h...
NP_353494     56 --SKT--MNSRHlkaangYSHAVDLAAlv--------------------------ggSVVWDWPLYAKLakamkqa---a 102 Agrobacterium f...

Feature 1                                    #  #    
2MXZ_A       105 ---gikLRFGadwnasgdyhdeikrgtyDGGHVELV 137 Escherichia phage T5
WP_020064836 319 ------FIWGgkw------------hnyDTIHFEYR 336 Brachyspira hyodysenteriae
WP_002950805 587 ------FIWGgrw------------vsfDTMHFEYR 604 Campylobacter showae
WP_007922476 142 ------FTWGks--------------fnDPMHFEVN 157 Pseudomonas sp. GM17
WP_017696942 101 yaksigFEWGgdwk-----------gfvDQPHLQFN 125 Bacillus subtilis
WP_005985971 212 ------WEWGgdwt-----------slkDYMHFEKV 230 Desulfovibrio africanus
WP_019999595 189 ------WEWGgdwk----------qgtmDYMHFQKI 208 Desulfovibrionaceae
WP_017373442  99 qelginIIWGgdwk-----------tfkDGVHFELE 123 Enterobacteriaceae bacterium LSJC7
WP_004641729 125 ayiaerKKLGkks-------------flDGVHFEID 147 Acinetobacter haemolyticus
NP_353494    103 kelgipLEWGgdwk-----------sfkDGPHFQLP 127 Agrobacterium fabrum str. C58

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