1WHR


Conserved Protein Domain Family
R3H_encore_like
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cd02642: R3H_encore_like 
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R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H domain is a potential regulator of DBF1 activity in stress responses. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the domain is predicted to bind ssDNA or ssRNA in a sequence-specific manner.
Links
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Statistics
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PSSM-Id: 100071
Aligned: 32 rows
Threshold Bit Score: 51.4493
Created: 28-Mar-2005
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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RxxxH motif
Conserved site includes 2 residues -Click on image for an interactive view with Cn3D
Feature 1:RxxxH motif
Evidence:
  • Comment:The RxxxH motif gives R3H domain its name.
  • Citation:PMID 9787637
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                 #   #  
1WHR_A        29 DRMMLLKLEQEILEFINDnn---------------------nQFKKFPQ-------------------MTSYHRMLLHRV 68  human
XP_502744    190 ARNHVLKIEQSILSLVATsteegtpadpknegtpevtnnaedEPSSFQSpsplpnlp----shvtvegPTPYHRLLIYKL 265 Yarrowia lipoly...
XP_502744     16 SRLLVLKIEKQLQQFLDAq----------------------kNASLLPPtapvaqqqqhkppsltldsMNSFNRLLTHRI 73  Yarrowia lipoly...
CAN65177      16 CKHLVLSIEEALVNFLQDdns-------------------ldGVMELEP-------------------MNPYERLLVHRL 57  wine grape
EAY72159     114 SKHLVLSTEETLVGILQNqyhnsdddeded-divaayrgtnrNILELQP-------------------ASSYQRLLLHRL 173 Indian rice
XP_973748    171 SLEQVKQSEDDLIAFFKSt----------------------pSQVYVKCp------------------ASYFERLLLHAI 210 red flour beetle
XP_653901    118 QNSFVQTIDKLILNYIKNkd---------------------sDILEFKL-------------------ENNYERLLCHAI 157 Entamoeba histo...
XP_001767100 257 DRLTILRLEQEVERFIRNps---------------------lQILEFQPm------------------PSSYLRLAAHRV 297 Physcomitrella ...
CAO64134      81 ERLSILRMEQDIEKFIHDpt---------------------qQQLEFQQl------------------PTSYLRLAAHRV 121 wine grape
NP_001105871  52 HRLMVLRMELDIQNFMQNpq---------------------lQEFEFQNf------------------PTSYLRCAAHRV 92  maize

Feature 1                                          
1WHR_A        69 AAYFg-----MDHNVDQt-------gKAVIINKT 90  human
XP_502744    266 VQYYn-----FTYDVDEk-------tHKITIYRP 287 Yarrowia lipolytica CLIB122
XP_502744     74 AEYYg-----LDHVVVDg--------HAVKIFYR 94  Yarrowia lipolytica CLIB122
CAN65177      58 ADIFgpsilvSDIIWQYqesq-pptmSHQLLRRN 90  wine grape
EAY72159     174 ADIYg-----FVHESVGeg-----edRHLVLQRC 197 Indian rice
XP_973748    211 AQYHd-----LQSLGMNed-----gnKRVEIYNT 234 red flour beetle
XP_653901    158 ADYYn-----LNSYSTGng-----kfRVTRVNTS 181 Entamoeba histolytica HM-1:IMSS
XP_001767100 298 AQHYn-----LQSMVVDggs---aegTRIVAKKT 323 Physcomitrella patens subsp. patens
CAO64134     122 AQHYs-----LQSMVLLdnnlpdgsgSKIIVRKT 150 wine grape
NP_001105871  93 AQHYg-----LETIVADslve--gsvSRIVARKT 119 maize

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