1KKH,2OI2,2X7I,3K17


Conserved Protein Domain Family
ERG12

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COG1577: ERG12 
Mevalonate kinase [Lipid transport and metabolism]
Mevalonate kinase is part of the Pathway/BioSystem: Isoprenoid biosynthesis
Statistics
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PSSM-Id: 441185
Aligned: 256 rows
Threshold Bit Score: 90.6721
Created: 9-Feb-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1KKH_A        10 TPSKVILFGEHAVVYGYRAISMAIDL-TSTIEIK--ETq----EDEIILNL-NDLnk--sLglnlneikNINPNn----- 74 
AKM81032       5 YSGKVILSGEHSVVYGYQAVLASLDL-GISCIAK--EGs---------LSH----------------------------- 43 
WP_011371153   9 TPAKLILTGEHAVLFGAPALSMAVDL-PTQCDMNftPDtgskePSCLEIEL-SDFnhkqiY--------PLSIwqqrvie 78 
WP_011996656  10 TPAKLILSGEHAVVYGHPALSVAINR-YMEATVR--WSl----PLHFSFHF-MGIdfrreV--------TLQALrnlkrk 73 
WP_013835949   8 APAKLILSGEHAVLYDCPALAVAIDL-PTQVSLHfdEQa----PAGLHLEL-ADLqhqawL--------SWDEVisrkqt 73 
WP_014202200   7 YYAKILLFGEYGIINDSQGLSIPYDFyRGAFKQS--DA-----LEGKSEKSnTSL------------------------- 54 
WP_065653749 409 APGKLILSGEHAVVHGAPAIAIAINR-YTTTTVS--KQ-----QQDLSFHF-ESLkhkseY--------SYDKLsdlkqr 471
WP_060774404  10 SPGKIILSGEYSVLYGASALATSISL-RLTASIV--ALe----KPVIRLLG-KEIie-----------kSLEECeklihh 70 
WP_102243451  10 FYSKVILFGEYSMIQHSMGLVIPYTLfDGKLTFR--RD--------NSAIIdPEL------------------------- 54 
WP_130536892  16 SPAKLIVSGEHAVVYGQPALSIPIPL-LSHCQINisAAd----KTHFEIAL-SDLaqsqeF--------SLADVeqltsn 81 
1KKH_A        75 -FGDF-KY------CLCAIK--------Nt-------LDYL---NIEPKtGF--KINISSKIPISCGLGSSASITIGTIK 126
AKM81032      44 -EQKSdLY------LQHILE--------Mf-------SKLA---QIKEI-QL--ALKIKSNLPQKSGLGSSAAFAAAVFS 95 
WP_011371153  79 iETRFaLYekqalsIQSVLQqpvdlillTfq----qfHNAY---RLKPG-HW--GVKLQSHQLTGKGLGSSASVIISLLQ 148
WP_011996656  74 lKKQYhKYslghlsIREVLQkpfelslfTfi----nvLDRLk-nKLP-T-GI--DIVTDSNIPVGCGMGSSAASVVSLIY 144
WP_013835949  74 lDSRYdAFqrgqrpINRLLTrpsdlvvlAl------tSQPLp-nSVLQQ-AC--LLKLSSQSWMGRGLGSSAACLLAMLA 143
WP_014202200  55 --KKYfQY------LKELQE--------SgeiiapldLISLe------A-DIeaGFYFDSSIPEGYGVGSSGALCAAIYD 111
WP_065653749 472 iKRAHqRFmqgelgIRDVLQkpfellqfTas----hsIDMIkpsTLA-H-GV--NIHTESDIPIGCGMGSSAAGIVSLNY 543
WP_060774404  71 iDQQYeKFvsgflpITSVLQkmsdlqfyIl-------GRYFn--SLSRQ-GI--SMKINSEIPIASGFGSSSSIISAIAL 138
WP_102243451  55 --KAFsLY------LKQLIE--------SnqlniqfdVTSFe------F-DIsqGLYFDSTIPQGYGVGSSGALVAAVFD 111
WP_130536892  82 iEMRYkHFqdntltIDQVLKtdfdliliTlk----kfSDFC---KIPTG-RW--QIIISSEIPLERGLGSSASIIVSLLK 151
1KKH_A       127 AVSGFYNK---E----LKDD---EIAKLGYMVEKEIQGKASITDTSTITYKGILEI-KNNKFRKIkgefeE---F-L--- 188
AKM81032      96 ELADFYNY---S----LNQD---RLYKLVLEAENFIHGRSSGADPAIVVYGGLIAFsQGKv-EHL-----------Pdla 153
WP_011371153 149 SLFSHHKL---S----YSDV---ELLSIAQRVESHQHGSSSGLDPTTVLKGGLLRYqQGSPLQQL-----T-----S--- 205
WP_011996656 145 VLTQFLGM---D----LHLE---DYLSLGVESENLQHGYSSGLDVHTVYHGGCLRYeKGQf-EKR-----P---I-P--- 201
WP_013835949 144 AWQTFTAV---DstrpLDRN---RLIQEAQHLENWQHGCSSGLDPSIIAQGGVGRFeRATGLTPL-----S---SwP--- 206
WP_014202200 112 KYAVn-RIdpdTd---IDKNsivELKKILGQMESYFHGKSSGLDPLICYLKLPVLIsSKEELGTV-----A---L-P--- 175
WP_065653749 544 AMSLFFKQ---R----ISDK---EQFELSLTAENMQHGQSSGIDIMLSLHGGCRQFqQGEs-KTL-----P---A-P--- 600
WP_060774404 139 ASATFVEK---Pf---ESKE---QLISEVRYIERLQHGRSGMIDATTIVYGGIVHIrNTI--KKLk----S---L-P--- 196
WP_102243451 112 RYEQ-------Es---HSNLdisKLKRIFAQMESHFHGASSGMDPLISYLNSPILIkNKNDLGPV-----T---L-P--- 169
WP_130536892 152 TLEKVSQS---K----LLDN----FFSLAQAIENYQHGNSSGLDPTTIYQNRPLIYqNQKf-SEL-----NlgkL-P--- 210
1KKH_A       189 -K----NCKFLIVYAeKRK-KKTAELVNEVAKIENKD----EIFKEIDKVIDEALKI---KNKEDFGKLMTKNHELLKK- 254
AKM81032     154 lA----KKSFFLIDS-GIAdESTGEMVAKVAANKSSRp----FIDEIGGISQKMIVDlknSfFN--PQLLNENQALLEE- 221
WP_011371153 206 -H----HFHGWIIDT-GTPeSTTGQAVNQVHREFsh---qhPIWTEFKNVAQLIEQAwqdSDAPQLKQAIKHNQQLLET- 275
WP_011996656 202 ------DFPMQLIQT-GCPqSSTGECISEAAPFFkn----sKIGEDFSAVTNALDQAlqnHNNDSIKGCIRENHRLLRS- 269
WP_013835949 207 -------LNAWLIDT-GAPaSSTGDCVTEVARRFda---saAIWREFKQVTEQMQQAwlsQDLAGLQQQLNANHQLLVN- 274
WP_014202200 176 -KpgqgKGAIFLLNS-GQP-GETQPMVNIFMEKMKNHgfrnVMKEEFTKYNDACIQAflkGDTKPLFSNLKKLSHLVFEy 252
WP_065653749 601 ------TFPLRVINT-GTPeSTTGECVKATRDYFKKNp---ALTEQFALVTNQLEHAiinQDQANFIKAVRANHRLLCE- 669
WP_060774404 197 -------GEWWAVNT-GKPeSSTGECITAVNKAFgn----sTIWDKFNSVTNDIIDTlntGNETALINAIKQNQLLLET- 263
WP_102243451 170 -KfpkgKGGLFLLNT-KRS-RKTEPLVNLFLEKTTNArfndICETQLKPITNNCIENflaADMETLTENFKKLSEFQFEh 246
WP_130536892 211 -Q----PLNAWLIDS-GKSkSSTGDTVSHVRNHFkt---hhDIWQQFSNTTQQLLTAwqtNNAQSLLKCIHSNQQLLCQ- 280
1KKH_A       255 LN-ISTPKLDRIVDIGNRFGf-GAKLTGAGG-----GGCVIILV 291
AKM81032     222 IG-IIADSVKDTIRQLQKLGa-FCKITGAGGlk-sgSGFILAFH 262
WP_011371153 276 IG-VVPPTVQRFIHTLNQSSesAAKICGAGSvsgekAGIVLCIS 318
WP_011996656 270 IG-VVPDKVNNFVIDVEKLGg-AAKICGAGSvvgdnGGIVLVIA 311
WP_013835949 275 LG-VVPSALTEPIAQLQRHG--GVKLCGAGSvsgdaGGVLLYVG 315
WP_014202200 253 FTpMIPSSVHELWKKGIETNayYLKLCGSGG-----GGFVLGFT 291
WP_065653749 670 LG-IVPNKVQTLISALEDTGa-AAKICGAGTvtgqhAGIVLVIS 711
WP_060774404 264 IG-IVPESVRQFIRCVEKKGg-AAKVSGAGSmkgenAGLVIVRG 305
WP_102243451 247 LSpMIPKLYRDVWVEGIKGGdfALKLCGAGG-----GGFLMGIT 285
WP_130536892 281 IG-VVPKTLQTWLTELEQQTagVGKVCGAGAiegdsAGIVLFLS 323
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