1OCO,1V55


Conserved Protein Domain Family
Cyt_c_Oxidase_IV

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cd00922: Cyt_c_Oxidase_IV 
Click on image for an interactive view with Cn3D
Cytochrome c oxidase subunit IV. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of prokaryotes. It catalyzes the reduction of O2 and simultaneously pumps protons across the membrane. The number of subunits varies from three to five in bacteria and up to 13 in mammalian mitochondria. Subunits I, II, and III of mammalian CcO are encoded within the mitochondrial genome and the remaining 10 subunits are encoded within the nuclear genome. Found only in eukaryotes, subunit IV is the largest of the nuclear-encoded subunits. It binds ATP at the matrix side, leading to an allosteric inhibition of enzyme activity at high intramitochondrial ATP/ADP ratios. In mammals, subunit IV has a lung-specific isoform and a ubiquitously expressed isoform.
Statistics
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PSSM-Id: 238462
Aligned: 32 rows
Threshold Bit Score: 109.283
Created: 11-Apr-2003
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
  next features
Conserved site includes 12 residues -Click on image for an interactive view with Cn3D
Feature 1:Subunit IV/I interface [polypeptide binding site]
Evidence:
  • Structure:1OCO_Q: Interface with 1OCO_N (subunit I), defined using 3.5A contacts
  • Citation:PMID 8638158

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                         ###                                                         
1OCO_Q      4 SVVKSEDY-----ALPSYVDRRDYPLPDVAhv-knLSASQKALKEKEKASWSSLSIDEKVELYRLKFKESFAEMNRSTn- 76  cow
O74988     24 QPSGEAMI-----ARPRLVDLDKRWGIMSQe---eKDGLITDLYARQKQPWTTLSIEEKKAAYWIAFGEHGPRAFSHI-- 93  fission yeast
O93980     51 RAASEHAI-----SNPTLAGIEKRWEAMPPq---eQAELWMQLRDRMKVDWHQMTLQEKKAAYWISFGPHGPRSVPPKg- 121 Aspergillus niger
P06810     26 RAASTMPI-----SNPTLANIEKRWEQMPMq---eQAELWMALRDRMKGNWADLTLQEKKAAYYIAFGPHGPRALPPPg- 96  Neurospora crassa
P00425     11 RLTGTRFVqtkalSKATLTDLPERWENMPNl---eQKEIADNLTERQKLPWKTLNNEEIKAAWYISYGEWGPRRPVHGkg 87  baker's yeast
AAC47845    3 KIFFRRYVa----SQPLGINIPDPPPREYLpngepKTYRLNQRYYNHKYDWERWTLRPAGVFHTYVYGEFAKDHKPLL-- 76  malaria parasite P...
XP_761612  41 GAFIEGPNkv--qLSHVVPNIEASWKTLSKe---eQYGVFRQLEELQRKDWKELSLDEKKAAYFVSFGPHGPRKPLTSpg 115 Ustilago maydis 521
AAW46234   26 SVTSTRSNa----SAPLLGNIEASWKTLPAe---eQYEVYQQLEQLQKKNWKELTIDEKKAAYFVAFGPHGPRTPANEpg 98  Cryptococcus neofo...
XP_504953  18 STRAAHVI-----STPTLINIEKRWEFMPAe---eREDIVHQLTERQKVNWSDLTLAEKQAAWYISYGPWGPRKPVHNpg 89  Yarrowia lipolytic...
EAT90926   23 TRQSSHAI-----SNPTLANIEKRWEDMPPq---eQADLWMSLRDRMKVDWKEMTMQEKKAAYYIAFGPHGPRRPPPPd- 93  Phaeosphaeria nodo...
Feature 1     #      #   #      #   #          # #  ##                             
1OCO_Q     77 EWKTVVGAAMFFI---GFTALLLIWEKHYv--yGPIPHTFEEEWVAKQTKRMLDMKVAPiQGFSAKWDY 140 cow
O74988     94 SQKTVFWGTVAGL---TIGVVLFGLIRTQa---APSPRTMTREWQEKSNEYMKENKINPiSGEASEGFK 156 fission yeast
O93980    122 ENLKIFFKVAQLT---LVSFGIFYVIHLFa---KPQPKTMTKEWQEASNEYAKQEKINPiYGISAEGYE 184 Aspergillus niger
P06810     97 EQKKVLAYTVAGV---FLSFVIFATMRAFa---KPPPATMTKEWQEATNEFLKAQKSDPlTGLTSEGYN 159 Neurospora crassa
P00425     88 DVAFITKGVFLGL---GISFGLFGLVRLLa--nPETPKTMNREWQLKSDEYLKSKNANPwGGYSQVQSK 151 baker's yeast
AAC47845   77 AWLLQYPIPLAFIpyfLFAFGLSFAFHHIsy-lGIKPKRFTVEWVEANKERERAENTNPiTRYLDRRRK 144 malaria parasite P. falciparum
XP_761612 116 QGAKTLGGVLAAL---GITSGIFYLMRANg---GAPVKTMTKEWQEASNELALEQKQNPiTGIASENYK 178 Ustilago maydis 521
AAW46234   99 HSLKVFVGVAALV---GTAYAVFELARSQa---APPPRTMTTEYQEQMNEYMRSQNMNPiSGVSSEGYK 161 Cryptococcus neoformans var. ...
XP_504953  90 DQTKIFVGIGIGL---AASVAIFGLCLALqpadNVALRTQSFEWQEKSNEILKEVGANPfTTYNQIQSP 155 Yarrowia lipolytica CLIB122
EAT90926   94 EGRNVFFLSAGVI---CAAFAIFAFTRMFa--sPIRPRTMTKEWQEASEEYLKSQGTEPiTGYKGMLVQ 157 Phaeosphaeria nodorum SN15

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