Conserved Protein Domain Family
THRAP3_BCLAF1
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pfam15440: THRAP3_BCLAF1 (this model, PSSM-Id:406009 is obsolete and has been replaced by 464718)
THRAP3/BCLAF1 family
This family includes thyroid hormone receptor-associated protein 3 (THRAP3), which is a spliceosome component and a subunit of the TRAP complex which plays a role in pre-mRNA splicing and in mRNA decay. It also includes the transcriptional repressor Bcl-2-associated transcription factor 1 (BCLAF1).
Links
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Statistics
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PSSM-Id: 406009
Aligned: 31 rows
Threshold Bit Score: 294.376
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_014352806 126 RSRSRSPKRRSV-TPRSRSCSRNSD-----------------------RSSSGrs--rsSSSGSSSHHSRSGS-SKRRSV 178  coelacanth
XP_006007788 108 RSRSRTPKRRSVsSPRSRSRSHHSD-----------------------RSSvsr---gsSSSRSSSCYSQSPVpSKLRSS 161  coelacanth
XP_015204121 112 RSRSRSPKRRST-SQRSRSKSHHSA-----------------------RSSasr---rsSSSRSSSLYSRSPApAKSRGS 164  spotted gar
XP_008112728 109 RSRSRSPKRRSRsSQRSRSRSRRSY-----------------------RSSrsp---rsSSSRSSSPYSKSPVsSKRRGS 162  green anole
XP_008526466 115 RSRSRSPKRRSVsSQRSRSRSRRSY-----------------------RSSrsp---rsSSSRSSSPYSKSPV-SKRRGS 167  Przewalski's h...
XP_012818154 103 RSRSRSPKRRSAsSPRSRSRSGHSY-----------------------KSSpsp---rsSSSRSSSKHSKSPV-IKIHTT 155  tropical clawe...
XP_011479419 142 RSRSRTPKKRSP----SRSRSRYSD-----------------------RSSSGpsrhsrRSSYSSRSHSSSPR-HRSSKG 193  Japanese medaka
XP_011483948 111 QNRSGSP---------PQGQSHRTD-----------------------RSFSPlsr-hsHHSSSS-THSSPPK-ARQATG 155  Japanese medaka
XP_015204191 133 RSRSRSPKRRSG-TPRSRSRSRysdrsssgrsrrtrgssssdsrsssthsRSGssk-----rnAAKELKESGR-PDSAAK 205  spotted gar
XP_007484673  63 nnrgmrrpygyrgrgrgyyqggggryhrggyxskrrsvssqrsrsrsrrsyrssrsprssssrssspyskspvssKRRGS 142  gray short-tai...

XP_014352806 179 KQHNAAQKEARASLPPAQVSQGAESKAKppadatsndskdpeaiskpwkgltaydsspkhpssvvhsvnasglnSPP-HP 257  coelacanth
XP_006007788 162 LEKQPKKTEGVLSEDKASGSRQQEEKKDlgkfepdqsklhdefskv-----------stlggdswpglsayndnSPRsHQ 230  coelacanth
XP_015204121 165 QDKASKKSEGGKEEGS---GRQLEEEKGdgkaeqpaiatsaksdlkr---------tpaviteswigisayndtSP--HR 230  spotted gar
XP_008112728 163 SEKQAKKTEAATLQESPLKNKSQEEEKSafehdpseplddfnks--------------aaasgdiwpglsaydnSPRsPH 228  green anole
XP_008526466 168 QEKQTKKAEGEPQEESPLKSKSQEEPKDtfehdpsesidefnks--------------satsgdiwpglsaydnSPRsPH 233  Przewalski's h...
XP_012818154 156 QDKPGQKTEDYNKSESPA-NKSCDEQKDafdpsepldelgkel----------------dlhgdtwaglsaydnSPRsPC 218  tropical clawe...
XP_011479419 194 RRSSKDVKDKRTEGSAEKpgqvgeggniek---------------------------------asggkwidfdaSPK-RG 239  Japanese medaka
XP_011483948 156 LASQTSEDVKDGELTSKQVQKGGEEDEEpeehvelleenpt--------------------egagsgksdgnwqSPK-KN 214  Japanese medaka
XP_015204191 206 EAQRAGSRDEEAAGAAGGegapdrasgs-------------------------------------wqglidydtSPK-RT 247  spotted gar
XP_007484673 143 LEKQTKKPEGAPPEDSPLKNKSQDEQKDtfehdpsepiddfnks--------------saasgdiwpglsaydnSPRsPH 208  gray short-tai...

XP_014352806 258 SPiqk-------------spLQSVAVKRSPPQKSPQSHSPAGPSSLRQSPVPPipp-------------lrtVPRQSPQA 311  coelacanth
XP_006007788 231 SP---------------------------SPVPTPTSHSSSRSDVALQSIAHSasgsskigaptqrshsiqrSPERAGS- 282  coelacanth
XP_015204121 231 SP---------------------------SPIPTPPSQSSSRSDTAAHQVASKisppslpa---lrlhslqhSPD----- 275  spotted gar
XP_008112728 229 SP---------------------------S-IASPPSQSSSCSDAHLLSTVHSakdtpqh------shsiqhSPERSGSG 274  green anole
XP_008526466 234 SP---------------------------SPIATPPSQSSSCSDAPMLSTVHSakntpsq-----hshsiqhSPERSGSG 281  Przewalski's h...
XP_012818154 219 SP---------------------------SPVTSPPSHSSSHSACPVMNVVRCakdtlse-----nihsivhSPEISGSG 266  tropical clawe...
XP_011479419 240 SP---------------------DRKKEGTPSTSEGRGGGASMWKSVGSPSPP--------------------------- 271  Japanese medaka
XP_011483948 215 S-------------------LGPSSVGQKSPSPGQTINTKISNDTSNGAPV----------------------------- 246  Japanese medaka
XP_015204191 248 SPavrsaiivsqgtahpspsLQSVAVKR----PSPAVKG--------GSPSPSrssaaaqskslgnapwqssGP------ 309  spotted gar
XP_007484673 209 SP---------------------------SPVATPPSQSSSCSDAPMLSTAHSakntpsq-----hshsiqhSPERSGSG 256  gray short-tai...

XP_014352806 312 ---HSPKRSSPAERSPV-----RKsppiistsynnaqkeesr-------agestsplvssylkryleEQKNKATTQDREN 376  coelacanth
XP_006007788 283 ----NTSRYSPSQDSPLhhmssRKspvksvtgqslsreeargrssfysdteekelpksgkylkrytdEEETGAYLLDKSN 358  coelacanth
XP_015204121 276 ---DPLGHYSPSHDSPPyqtspRRspakafstvqssrgffpn-------sdeqdlpkvgkylkryteEDGGRAYLHERGN 345  spotted gar
XP_008112728 275 slgNGSSRYSPSQNSPLhhipsRRspakavasqnatreetrvrsf--ypeagepesskgakflkrytdEESRVYLLDRSN 352  green anole
XP_008526466 282 svgNGSSRYSPSQNSPIhhipsRRspaktitpqnaprdeargrssf-ypdggdqetaktgkflkrftdEESRVFLLDRGN 360  Przewalski's h...
XP_012818154 267 g--NGLKRYSPSQNSPLqm-stCKspaksvliqnpleeshyhysf---yadttkehanntkffdrytdEENKLFPIEKCI 340  tropical clawe...
XP_011479419 272 ------------PKSPA-----KSgqsatfsgfgffskdda---------kpadnsaisaafkkflaENKSKKQAAEKES 325  Japanese medaka
XP_011483948 247 ---WQSSGGTCSTRKPS-----REglnpmlssfdffsteef---------qdedkkaisiafrkfleEQSKKANTTA-EI 308  Japanese medaka
XP_015204191 310 ---------APTSKSPP-----QQsptavfsgfgffskddvr--------agekpssvstafkkfleEHKNKIQVAEWEN 367  spotted gar
XP_007484673 257 slgNGSSRYSPSQNSPIhhipsRRspaktippqnvpreetrirsf--ypdggdqetaktgkflkrytdEESRVYLLDRGN 334  gray short-tai...

XP_014352806 377 GREKDqk-akNEEREKVKERSGVSEMGV--PFFKSDYLAPKNESESLYRGIPSPRRYRYSNELEKsmSAEFQE--EALHS 451  coelacanth
XP_006007788 359 VKEKDgqkdrGLDKGRVEQDSEWEDQEAleYFEQKDSDKLPFLGDSEGEGGEKPDTYR---QFKVssQVEQVKsyLAETR 435  coelacanth
XP_015204121 346 GRDKEhqkdrLQEKGRGEG--DWGDQGGidPGVKKESEKVPFLGDSPDPEEDESQAYRQPYQFKVttQAEQVKnyPVESR 423  spotted gar
XP_008112728 353 VREKDaqkerGPEKGRTEGEREWEDQDAleYYMDKDSGKQKFI-DSEGEDAEETEDYR---QFRKsvLADQGKg-fSASH 427  green anole
XP_008526466 361 TRDKEtpkekGSEKGRAEG--EWEDQEAldYFSDKESGKQKFN-DSEGDDTEETEDYR---QFRKsvLADQGKnfATTSH 434  Przewalski's h...
XP_012818154 341 NKEKGtckerGTEKTKKGSSNVWDEHVAldYFLEKEPGNSQFLANSNSEDLEEAEDYR---QFRKsvLADQGKslSSVSN 417  tropical clawe...
XP_011479419 326 SREKEal-aaDREQEKSSKSAEIFSV-----------------SSSAYADSKDDKSLPFFDPEEE----EFLK--SQGLK 381  Japanese medaka
XP_011483948 309 SPKTEae-dgGLEKGNMNGKTSAM-------------------VSDCASGKCKEKTKG-----EVs-LKSFLKtpPFLST 362  Japanese medaka
XP_015204191 368 GREKEqk-maELERDKGNGKAGSFDKGAaySGLKPDYYSKNEE-----------EKYGYDDEFELgsAAEFLKgpQFGSA 435  spotted gar
XP_007484673 335 TREKEaqkekGTEKGRAEG--EWEDQETldYFsdkeagk-rkfndsEGDDTEETEDYR---QFRKsvLADQGKnfATASH 408  gray short-tai...

XP_014352806 452 MDMQ--ESEkkhrvkgl--kdskledePKCKSKVIVpSTAKNQDTYEERLSKWEE---LAYFPSAKEKSWEDE------- 517  coelacanth
XP_006007788 436 WNDD--DEG------------------NKFKTKIVLkGDRDYDRFGEDRAFKLKGs-gFGADRPSTSKEKYREd------ 488  coelacanth
XP_015204121 424 WNVEsqEEG------------------SKYKIKTSk-GERDYERFGEDRMFKFKNp-gYMLDR--LNKDKYGEe------ 475  spotted gar
XP_008112728 428 RNAE--EEG------------------SKYKSKISMkVNRESEGFREDKNYKLKEpasYVVERPNIPKDKHKEd------ 481  green anole
XP_008526466 435 RNTE--EEG------------------PKYKSKVSLkGNRESDGFREEKNYKLKEt-gYVVERPSTTKDKHKE------- 486  Przewalski's h...
XP_012818154 418 WNCE--EED------------------SKYKTKGLTrFSKEGEKFKVVRGSKSAE---------QVAKEKHK-------- 460  tropical clawe...
XP_011479419 382 ERVIp-DDA------------------D--AQRTP-----TARDIF----GKWGDepsISTSYSSKEKARREAadp---s 428  Japanese medaka
XP_011483948 363 EGEE--EDEilhrpslkflfkdlhngdESCKPKIS------AQKLFGEAFRKQQN--------AAYSQFTNGEf------ 420  Japanese medaka
XP_015204191 436 EAGE--DQEkrhkvrnq--keremedePKHKSKITI---TANRDMFDERFNKWDE---LAYFPSAKEKLRKEEdageddi 505  spotted gar
XP_007484673 409 RNAE--EEG------------------AKYKSKVSLkGNRESDGFREDKNYKLKEt-gYVverpsttkdk---------- 457  gray short-tai...

XP_014352806 518 -DMEDEVYPGR--AKREE--------VKRAELGGyrgpipdknprsgsykvvherspsppprrSAE---GKE-REKMATK 582  coelacanth
XP_006007788 489 -----DKFLERimIKREPvspeqvksEKLSERFDcs-------------------------plLQK---TLDlREKAASR 535  coelacanth
XP_015204121 476 -GKGTDKYDERitIKRETvspqqakaERFRELFDqs-------------------------plLQK---TLDmREKAALR 526  spotted gar
XP_008112728 482 -----EKISERt-MKKETqspeqvksEKLKELFDys-------------------------ppLHK---NPDsREKSTFR 527  green anole
XP_008526466 487 ----DDKSSERitVKKETqspeqvksEKLKDLFDys-------------------------ppLHK---NLDaREKSTFR 534  Przewalski's h...
XP_012818154 461 -----DKVTQRhsVMKDLlssdelkiEKTKDLFSyn-------------------------ltLHE---S-NvIEKNIFR 506  tropical clawe...
XP_011479419 429 dAMEDEMYQVRklSKKEEkskkkekkEKEKQ--R-----------------------------RSA---SPQmKERPLFP 474  Japanese medaka
XP_011483948 421 dSREEERWVER----KQDkaaaisavLAKRELTEkfedlspemsfk-----kkmmagspsvlaSAA---VSSnREMFMIR 488  Japanese medaka
XP_015204191 506 dDVEEELY--R--SRKQEraaaaaaaAKKAEASGyrgfspdkapkasrkkekqgqspspparkSSE---NRE-REMFNVR 577  spotted gar
XP_007484673 458 -hkeddksseRimVKKETqspeqvksEKLKELFDys-------------------------ppLHKnleA---REKStfr 508  gray short-tai...

XP_014352806 583 EENPpisk-ttfSVYRGSEINVRMdale-ddfgSS---VAHERRLSRDLVHGNKKDLGFRSIFQHIQSSQSRRSPSELFA 657  coelacanth
XP_006007788 536 EENLpkik-mvpSESYRPDVKLKMppvsfddpvRPgtsLTSDRLLASALVHSGKKEQGFRSIFDHIKLPQMYKSSAESFI 614  coelacanth
XP_015204121 527 DESPprvk-ivpGEASRPEVKVKIasla-yddpSPgtsLTSDRSLASALVHSTKREQGFRSIFDHIKRPQAYKNSAESFI 604  spotted gar
XP_008112728 528 EESPlrik-miaSDSHRPEVKLKMapvplddsnRPa-sLTKDRLLASTLVHSVKKEQEFRSIFDHIKLPQASKSTSESFI 605  green anole
XP_008526466 535 EESPlrik-miaSDSHRPEVKLKMapvplddsnRPa-sLTKDRLLASTLVHSVKKEQEFRSIFDHIKLPQASKSTSESFI 612  Przewalski's h...
XP_012818154 507 EESPvkmr-ivaTESPLPEVKLRIitvplddgrAPc--LDNERLLGSTLIHSVKKVQAFRTIFDHLKVPFTSRTSPESFM 583  tropical clawe...
XP_011479419 475 GAFPpsdp-spvRPLSASREDFELkfss--leeLPsssLSKDRLIPRDLPNSSKKDPEFRSIFQHVQSAQLRRSPSELFA 551  Japanese medaka
XP_011483948 489 EQDPap----vsSQKPEAKFHVRMgflg-dslmSSsdiLAEERQLSQDLVLSSKKDPEFRSIFQHVQTAQSQRSPSELFA 563  Japanese medaka
XP_015204191 578 RDDSpprstpaySGKRSAEVSVRMdpfh-edyaSSsgvLANERRFSRDLVHPSKKDQEFRSIFQHIQSTQLRRSPSELFA 656  spotted gar
XP_007484673 509 eesp-lrikmiaSDSHRPEVKLKMapvplddsnRPa-sLTKDRLLASTLVHSVKKEQEFRSIFDHIKLPQASKSTSESFI 586  gray short-tai...

XP_014352806 658 QHIVTIVHHVKEHHFESPEMTLSERFTMYQRRAMeqGAARSKKSPEFHRRIDISPSAFRKHPFLQDEMKGSREsssykge 737  coelacanth
XP_006007788 615 QHIVSLVHHVKEHYFKSTGMTLNERFTVYQKAt--eGQVPRQKSPEIHRRIDISPSALRKHTRLTDEDRLFKEesqkqgd 692  coelacanth
XP_015204121 605 QHIVSLVHHVKEHYFKSTGMSLHERFTAYQKAa--eGHEVRQKSPEIHRRIDISPSAFRK-------DRILKEdshk-ge 674  spotted gar
XP_008112728 606 QHVVSLVHHVKEQYFKSAAMTLSERFTAYQKSp--eEHSTRQKSPEIHRRIDISPSALRKHTRLAGEERAFKEetqk-gd 682  green anole
XP_008526466 613 QHIVSLVHHVKEQYFKSAAMTLNERFTSYQKAt--eEHSARQKSPEIHRRIDISPSALRKHTRLAGEERVFKEenqk-gd 689  Przewalski's h...
XP_012818154 584 YHVVSLVHHVKEHYFKGCGKTLNERFTDCLKDt--lDHVSHLRRPEIHRVIDIPPNIPKKHIRIQDEDKAIKKetak-ve 660  tropical clawe...
XP_011479419 552 QHIVSIVHYIKAQHFPSSDISLSERFAMYQRKAAeaEMMKPRKSPEIHRRIDVSPSAFKRHPHLFEDLDEssyk---dpg 628  Japanese medaka
XP_011483948 564 QHIVTIVHHVKTQHFPSSGLTLNERFTLYQREAAeqEMKKSRKSPEIHRRIDVLPSAFKKPPQLFGGVKSSEEgtyksag 643  Japanese medaka
XP_015204191 657 QHIVTIVHHIKAQHFESSGMTLNERFAMYQRRAA--EMMKPRKSPEIHRRIDVSPSAFRKHSHLFEEMKSSREssskdeg 734  spotted gar
XP_007484673 587 QHIVSLVHHVKEQYFKSAAMTLNERFTSYQKAt--eEHSTRQKSPEIHRRIDISPSALRKHTRLSGEERVFKEenqk-gd 663  gray short-tai...

XP_014352806 738 gKYKEDPVDLRLDIERRKKY--KERDHKRDGSRESVDSRDSSQSRERsTEKAQR---EHKESKKR-KKQkKIRSR----- 806  coelacanth
XP_006007788 693 kKLRCDSADLRHDIDRRRKErsRER-------EGSRGSRESSGSRKH--EKSTKdymDYKEYKPYkDESkPKNREg---- 759  coelacanth
XP_015204121 675 kKSRCDAADLRHDIDRRRKErsRDR-------DDSRGSREPSPSRKL--DKLGKefkDYKDYKSYkDDSkHKSKEre--- 742  spotted gar
XP_008112728 683 kKLKCDAADLRHDIDRRRKErsKER-------GDSKGSRESSGSRKQ--EKMPK---DYKDFKPYkDDSkQKREQdrsrs 750  green anole
XP_008526466 690 kKLRCDSADLRHDIDRRRKErsKER-------GDSKGSRESSGSRKQ--EKTPK---EYKEYKSYkDDSkHKSREqdhsr 757  Przewalski's h...
XP_012818154 661 kKKKSSLSDQRCDVQ-HKKEhsKER-------VDLTCSRESSNSQKK--EKPQK---ELKEFKIFkEESkRKKDL----- 722  tropical clawe...
XP_011479419 629 kKFKGDVMDLRLDIERRKRFagRERDYKREGGRSPEGSRGP--SREQsTEKSGK---HQKKSKKSk----KKRDRspsss 699  Japanese medaka
XP_011483948 644 eKVKGDTMDLRLDIERRKKYscFQNQNQE---RDVGDSADF--SKELcEQNLSK---HSNKLNGQk----RRRSS----- 706  Japanese medaka
XP_015204191 735 kKMKTDSMDLRLDIERRKKYssKEREHKRDGMRDSGESRGSSLSRERsTEKSSK---HHKKTKKRk----KTRER----- 802  spotted gar
XP_007484673 664 kKLRCdsadlrhdidrrrKErsKER-------GDSKGSRESSGSRKQ--EKT-K---DYKEYKSYkDDSkHKSReqdrsr 730  gray short-tai...

XP_014352806 807 --SKSSSTSSHSSQSYK 821  coelacanth
XP_006007788 760 -dHSRSSSSSSASRDDK 775  coelacanth
XP_015204121 743 -rSRSSSSSSLSREDNK 758  spotted gar
XP_008112728 751 ssTSSPSSSSSSSREEK 767  green anole
XP_008526466 758 ssSSSASPSSPSSREEK 774  Przewalski's horse
XP_012818154 723 --GPPHSPSSGSSHEEK 737  tropical clawed frog
XP_011479419 700 ssssspspypppfrgke 716  Japanese medaka
XP_011483948 707 -----SSSSSSSSKSPK 718  Japanese medaka
XP_015204191 803 --SRSSSESSSSSHSFK 817  spotted gar
XP_007484673 731 ssssssssssassreek 747  gray short-tailed opossum
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