1D2F


Conserved Protein Domain Family
MalY
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COG1168: MalY (this model, PSSM-Id:224090 is obsolete and has been replaced by 440782)
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Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism, General function prediction only]
linked to 3D-structure
Links
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Statistics
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PSSM-Id: 224090
Aligned: 21 rows
Threshold Bit Score: 410.137
Created: 7-Oct-2002
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1D2F_B     1 MFDFS------KVVDRHGT-WCTQWDYVAdrfGTADLLPFTISDMDFATAPCIIEALNQRLMHGVFGYSrWKNDEFLAAI 73  Escherichia coli
19553506   1 -MRFP------ELEELKNR-RTLKWTRFP-----EDVLPLWVAESDFGTCPQLKEAMADAVEREVFGYPpDATG-LNDAL 66  Corynebacterium glu...
15806468   8 PSDFSheffgsLDPQALAHpDSIKWQHYG-----EGVIPMWIADMDFPVAPPILRALEDRLTRG-LGYPlGRDDRLIADL 81  Deinococcus radiodu...
15214402   5 PLEQL------TIEQLQCR-TSMKWRAHP-----EDVLPLWVAEMDVLLAPTVAEAVHRAVDNGDTGYP-YGTT-FAEAI 70  Mycobacterium leprae
15839454   5 IFNLL------TEEQLRGR-NTLKWNYFG-----PDVVPLWLAEMDFPTAPAVLDGVRACVDNEEFGYPpLGEDSLPRAT 72  Mycobacterium tuber...
15841785   1 ----------------------MKWRAHP-----ADVLPLWVAEMDVKLPPTVADALRRAIDDGDTGYP-YGTE-YAEAV 51  Mycobacterium tuber...
17546559     --------------------------------------------------------------------------------     Ralstonia solanacearum
15607217   5 IFNLL------TEEQLRGR-NTLKWNYFG-----PDVVPLWLAEMDFPTAPAVLDGVRACVDNEEFGYPpLGEDSLPRAT 72  Mycobacterium tuber...
2492850    5 PLEEL------TLEQLRSQrTSMKWRAHP-----ADVLPLWVAEMDVKLPPTVADALRRAIDDGDTGYP-YGTE-YAEAV 71  Mycobacterium tuber...
126717     1 MFDFS------KVVDRHGT-WCTQWDYVAdrfGTADLLPFTISDMDFATAPCIIEALNQRLMHGVFGYSrWKNDEFLAAI 73  Escherichia coli

1D2F_B    74 AHWFSTQHYTAIDSQT-VVYGPSVIYMVSELIRQWSETGEGVVIHTPAYDAFYKAIEGNQRTVMPVALEK-QADGWFCDM 151 Escherichia coli
19553506  67 TGFYERRYGFGPNPES-VFAIPDVVRGLKLAIEHFTKPGSAIIVPLPAYPPFIELPKVTGRQAIYI-----DAHEY--DL 138 Corynebacterium glu...
15806468  82 QTKWASQGLTDVPADG-IHFTPSVVPGLYAGVHGLTEPGDRVVTMTPIYHPFHLAINDLGREVAAAPLRE-GDTRWEIDW 159 Deinococcus radiodu...
15214402  71 SEFASQRWQWHDLDVSrTAIVPDVMLGVVEMLRLITDRGDGVIVSPPVYPPFYAFVTHDGRRVLEAPLG--RDGRL--DL 146 Mycobacterium leprae
15839454  73 ADWCRQRYGWCPRPDW-VRVVPDVLKGMEVVVEFLTRPESPVALPVPAYMPFFDVLHVTGRQRVEVPMVQqDSGRYLLDL 151 Mycobacterium tuber...
15841785  52 REFACQRWQWHDLEVSrTAIVPDVMLGIVEVLRLITDRGDPVIVNSPVYAPFYAFVSHDGRRVIPAPLR--GDGRI--DL 127 Mycobacterium tuber...
17546559   1 ------------------MTGHAGMPPMKIDLQRIRRNRKGRRIDR------QRKRAAQCQGDAPAPLVL-EDGRYRFDA 55  Ralstonia solanacearum
15607217  73 ADWCRQRYGWCPRPDW-VRVVPDVLKGMEVVVEFLTRPESPVALPVPAYMPFFDVLHVTGRQRVEVPMVQqDSGRYLLDL 151 Mycobacterium tuber...
2492850   72 REFACQRWQWHDLEVSrTAIVPDVMLGIVEVLRLITDRGDPVIVNSPVYAPFYAFVSHDGRRVIPAPLR--GDGRI--DL 147 Mycobacterium tuber...
126717    74 AHWFSTQHYTAIDSQT-VVYGPSVIYMVSELIRQWSETGEGVVIHTPAYDAFYKAIEGNQRTVMPVALEK-QADGWFCDM 151 Escherichia coli

1D2F_B   152 GKLEAVLAKPE-------CKIMLLCSPQNPTGKVWTCDELEIMADLCERHGVRVISDEIHMDMVWGEQ-PHIPWSNVARG 223 Escherichia coli
19553506 139 KEIEKAFADGa--------gSLLFCNPHNPLGTVFSEEYIRELTDIAAKYDARIIVDEIHAPLVYEG--THVVAAGVSEN 208 Corynebacterium glu...
15806468 160 DALERAAEGAR---------LLMLCHPHNPCGRVWDADELARLRELVLAHDLYVISDELHADLRFTD--APFEAFAADPR 228 Deinococcus radiodu...
15214402 147 AALQDAFSRARrssgpngKVAYLLCNPHNPTGSVHTVAELHGVAELARRFGVRVISDEIHAPLVLSG--ARFTPY-LSIP 223 Mycobacterium leprae
15839454 152 DALQAAFVRGa--------gSVIICNPNNPLGTAFTEAELRAIVDIAARHGARVIADEIWAPVVYGS--RHVAAASVSEA 221 Mycobacterium tuber...
15841785 128 DALQEAFSSARassgssgNVAYLLCNPHNPTGSVHTADELRGIAERAQRFGVRVVSDEIHAPLIPSG--ARFTPY-LSVP 204 Mycobacterium tuber...
17546559  56 AIFEQAIRDDT--------RLFILSNPHNPTGNVWSEDDLRTMGEICLRHGILVIADEIHQDFVLAPSrRHIPFAALDPR 127 Ralstonia solanacearum
15607217 152 DALQAAFVRGa--------gSVIICNPNNPLGTAFTEAELRAIVDIAARHGARVIADEIWAPVVYGS--RHVAAASVSEA 221 Mycobacterium tuber...
2492850  148 DALQEAFSSARassgssgNVAYLLCNPHNPTGSVHTADELRGIAERAQRFGVRVVSDEIHAPLIPSG--ARFTPY-LSVP 224 Mycobacterium tuber...
126717   152 GKLEAVLAKPE-------CKIMLLCSPQNPTGKVWTCDELEIMADLCERHGVRVISDEIHMDMVWGEQ-PHIPWSNVARG 223 Escherichia coli

1D2F_B   224 --DWALLTSG-SKSFNIPALTGAYGIIENSSSRDAYLSALKgRDGLSSPSVLALTAHIAAYQQGAPWLDALRIYLKDNLT 300 Escherichia coli
19553506 209 aaNTCITITAtSKAWNTAGLKCAQIFFSNEAD-VKAWKNLS-DITRDGVSILGLIAAETVYNEGEEFLDESIQILKDNRD 286 Corynebacterium glu...
15806468 229 vrDRTLTVTGpCKAFNTAGLGIGVMVTHDPELLARVQRRVA--GLGGHPSALSFTMWRVALEDGGPWLARTVEYLRGNRD 306 Deinococcus radiodu...
15214402 224 gaENAFALMSaTKGWNLCGLKAAIAIAGREA--AADLRRIP-KEVSHGPSHLGIIAHTAAFRTGSSWLDALLQGLEANRA 300 Mycobacterium leprae
15839454 222 aaEVVVTLVSaSKGWNLPGLMCAQVILSNRRD-AHDWDRIN-MLHRMGASTVGIRANIAAYHHGESWLDELLPYLRANRD 299 Mycobacterium tuber...
15841785 205 gaENAFALMSaSKAWNLGGLKAALAIAGREA--AADLARMP-EEVGHGPSHLGVIAHTAAFRTGGNWLDALLRGLDHNRT 281 Mycobacterium tuber...
17546559 128 faAHSLTCTSaSKTFNLAGLQCANLIISDRRLRDTFIRQLE-RNQFNVVNLLGMVATEAAYAQGEPWLEAMLAYIRANQQ 206 Ralstonia solanacearum
15607217 222 aaEVVVTLVSaSKGWNLPGLMCAQVILSNRRD-AHDWDRIN-MLHRMGASTVGIRANIAAYHHGESWLDELLPYLRANRD 299 Mycobacterium tuber...
2492850  225 gaENAFALMSaSKAWNLGGLKAALAIAGREA--AADLARMP-EEVGHGPSHLGVIAHTAAFRTGGNWLDALLRGLDHNRT 301 Mycobacterium tuber...
126717   224 --DWALLTSG-SKSFNIPALTGAYGIIENSSSRDAYLSALKgRDGLSSPSVLALTAHIAAYQQGAPWLDALRIYLKDNLT 300 Escherichia coli

1D2F_B   301 YIADKMNAAFPELNWQIPQSTYLAWLDLRPLNIDD----------------NALQKALIEQEKVAIMPGYTYGEEG---- 360 Escherichia coli
19553506 287 FAAAELEKL--GVKVYAPDSTYLMWLDFAGTKIE-----------------EAPSKILREEGKVMLNDGAAFGGFT---- 343 Corynebacterium glu...
15806468 307 FMTAFLRERLPWVRFTVPEATYLAWLDLREHPEAG-----------------RIQEFLLEEAKVAVHNGPTFAPGEqgaa 369 Deinococcus radiodu...
15214402 301 LLRDLVTKHLPGVRYQRPQGTYLTWLDCRHLGFDeqinegl----aaisdlSGPARWFLDHSRVALTSGHAFGTGG---- 372 Mycobacterium leprae
15839454 300 HLARALPELAPGVEVNAPDGTYLSWVDFRALALP-----------------SEPAEYLLSKAKVALSPGIPFGAAVg--- 359 Mycobacterium tuber...
15841785 282 LLGALVDEHLPGVQYRWPQGTYLAWLDCRELGFDDaasdemteglavvsdlSGPARWFLDHARVALSSGHVFGIGG---- 357 Mycobacterium tuber...
17546559 207 HFAATVNAADWGLRVHEMDALYLAWIDCRPLGLSA----------------EALEHFMLTRARIWFDKGQKFGAEG---- 266 Ralstonia solanacearum
15607217 300 HLARALPELAPGVEVNAPDGTYLSWVDFRALALP-----------------SEPAEYLLSKAKVALSPGIPFGAAVg--- 359 Mycobacterium tuber...
2492850  302 LLGALVDEHLPGVQYRWPQGTYLAWLDCRELGFDDaasdemteglavvsdlSGPARWFLDHARVALSSGHVFGIGG---- 377 Mycobacterium tuber...
126717   301 YIADKMNAAFPELNWQIPQSTYLAWLDLRPLNIDD----------------NALQKALIEQEKVAIMPGYTYGEEG---- 360 Escherichia coli

1D2F_B   361 -RGFVRLNAGCPRSKLEKGVAGLINAIRAVR 390 Escherichia coli
19553506 344 --TCARLNFACSRETLEEGLRRIASVL---- 368 Corynebacterium glutamicum ATCC 13032
15806468 370 yQGFIRVNFATSRAILTEALERMARALDTRQ 400 Deinococcus radiodurans
15214402 373 -VGHVRVNFATSQAILIEALSRMGRALVNFR 402 Mycobacterium leprae
15839454 360 -SGFARLNFATTRAILDRAIEAIAAALRDII 389 Mycobacterium tuberculosis CDC1551
15841785 358 -AGHVRINFATSRAILIEAVSRMSRSLLERR 387 Mycobacterium tuberculosis CDC1551
17546559 267 -HGFLRANLGCPRAVVDDALARLAGAM---- 292 Ralstonia solanacearum
15607217 360 -SGFARLNFATTRAILDRAIEAIAAALRDII 389 Mycobacterium tuberculosis H37Rv
2492850  378 -AGHVRINFATSRAILIEAVSRMSRSLLERR 407 Mycobacterium tuberculosis
126717   361 -RGFVRLNAGCPRSKLEKGVAGLINAIRAVR 390 Escherichia coli
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