1I7X


Conserved Protein Domain Family
Cadherin_C
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pfam01049: Cadherin_C (this model, PSSM-Id:395833 is obsolete and has been replaced by 460041)
Cadherin cytoplasmic region
Cadherins are vital in cell-cell adhesion during tissue differentiation. Cadherins are linked to the cytoskeleton by catenins. Catenins bind to the cytoplasmic tail of the cadherin. Cadherins cluster to form foci of homophilic binding units. A key determinant to the strength of the binding that it is mediated by cadherins is the juxtamembrane region of the cadherin. This region induces clustering and also binds to the protein p120ctn.
Links
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Statistics
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PSSM-Id: 395833
Aligned: 99 rows
Threshold Bit Score: 105.761
Created: 22-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1I7X_B          2 RRTVVKEPLL---PPDDDTRDNVYYYDEEGGGEEDQD-FDLSQLHRGLD------------------------------- 46  
XP_022529863 2507 RGVYHIPAEH---ESWEDIRENILNYNEEGGGEQDQNaYDITELKRPLCsslsqsss----------------------- 2560 Mexican tetra
XP_006641429  609 RKRYRKDALVnlsKGSGEIHEQLVSYDEEGGGEMDTNgYDVSVLNSA--------------------------------- 655  spotted gar
NP_001100877  613 RRRLRKQAHAh-sKSALEIHEQLVTYDEEGGGEMDTTsYDVSVLNSV--------------------------------- 658  Norway rat
XP_006941627  620 RLRKQARAHG---KSVPEIHEQLVTYDEEGGGEMDTTsYDVSVLNSVRQgga---------------------------- 668  domestic cat
BAG62074       60 RRRLRKQARAh-gKSVPEIHEQLVTYDEEGGGEMDTTsYDVSVLNSV--------------------------------- 105  human
XP_008112170  611 RKRHKKDLNVl-kKNVEEIHEQLVAYDEEGGGEMDTNsYDVSVLTSA--------------------------------- 656  green anole
XP_009873729  150 RKRHKKDLSGl-gRNVAEIHEQLVTYDEEGGGEMDTTsYDVSVLNSA--------------------------------- 195  bar-tailed tr...
KAE8608348    618 RRMQKKNTNIl-gKNTAEIHEQLVTYDEEGGGEMDTNsYDVSVLNSV--------------------------------- 663  tropical claw...
XP_029694384 2188 RGVYHIPAEH---ESWEDVRENILNYNEEGGGEQDQKgYDITELKRPLCsslsqssscttapliksspgsqeevhpsgss 2264 torafugu

1I7X_B         47 ---------ARPEVTRNDvaptlmsvpqyr---------------prpanpdeignFIDENLKAADSDPTAPPYDSLLVF 102 
XP_022529863 2561 --cttapliKSSQGSQEEvlpggllpyhhnp-------------gcsthcamdfknYVARIIWEADNDNLALPMDTYHVY 2625 Mexican tetra
XP_006641429  656 ---------------RHNnvrpepslyakv---------------qkptgkadmaiMIEVKKDEADHDKDGIPYDTLHIY 705  spotted gar
NP_001100877  659 ---------------RTGsnkplrstmdarpavytqvqkpprlapslhggprematMIEVKKEEADNDGGGPPYDTLHIY 723  Norway rat
XP_006941627  669 ------kppRPALEARPSvyaqvqkpprhg---------------avhggpgemaaMIEVKKDEADHDGAGPPYDTLHIY 727  domestic cat
BAG62074      106 ---------------RRGgakpprpaldarpslyaqvqkpprhapgahggpgemaaMIEVKKDEADHDGDGPPYDTLHIY 170  human
XP_008112170  657 ---------------RQKgmmsprmtmepmpctysq---vqkvpehglsgtgemgiMIEMKKDDADNDGGLLPFDTLHIY 718  green anole
XP_009873729  196 ---------------RKNgikpeavpspyaqvq--------kppgntisgagememMIEVKKDEADNDRDLLPYDTLHIY 252  bar-tailed tr...
KAE8608348    664 ---------------RRNvqrprqemeaspyly---------ahvqkptrngdmsfMIEVKKDEADNDGEGLPYDTLHIF 719  tropical claw...
XP_029694384 2265 cssgapylsMAHQHPSLGaysdyaavvsra--------------gpephshahfktYVSRIVWEADNDFQAFPPDSYHVW 2330 torafugu

1I7X_B        103 DYEGSGSEAASLSSLNS------------SES-DQDQDYDYLNEWGNRFKKLADMYGGG 148 
XP_022529863 2626 CIEGEGSGAGSLSSLSS------------AIP-EEEFSYDCLRNWGPKFEGLSEMYRRP 2671 Mexican tetra
XP_006641429  706 GYEGPESLAGSLSSLET------------SSS-DSNLDYDFLNDWGPRFKTLAELYGVD 751  spotted gar
NP_001100877  724 GYEGTESIAESLSSLST------------NSS-DSDIDYDFLNDWGPRFKMLAELYGSD 769  Norway rat
XP_006941627  728 GYEGSESIAESLSSLGT------------DSS-DSDVDYDFLNDWGPRFKMLAELYRSD 773  domestic cat
BAG62074      171 GYEGSESIAESLSSLGT------------DSS-DSDVDYDFLNDWGPRFKMLAELYGSD 216  human
XP_008112170  719 GYEGAESIAESLSSLGS------------GSS-DSDLDYDFLNDWGPRFKMLAELYGLE 764  green anole
XP_009873729  253 GYEGAESIAESLSSLES------------GSS-DSDIDYDFLNDWGPRFKMLAELYGSE 298  bar-tailed trogon
KAE8608348    720 GYEESESIVESLSSIES------------GSS-ESDIDYDVLNNWGPRFKMLADLYGLE 765  tropical clawed frog
XP_029694384 2331 CVEGSGSLAGSLSSLGSvtscrdidrggeEEKdNGGFVCNRLSQWGPKFRILSDMYDRP 2389 torafugu
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