Conserved Protein Domain Family
TraB
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pfam01963: TraB (this model, PSSM-Id:396512 is obsolete and has been replaced by 426534)
TraB family
pAD1 is a haemolysin/bacteriocin plasmid originally identified in Enterococcus faecalis DS16. It encodes a mating response to a peptide sex pheromone, cAD1, secreted by recipient bacteria. Once the plasmid pAD1 is acquired, production of the pheromone ceases--a trait related in part to a determinant designated traB. However a related protein is found in C. elegans, suggesting that members of the TraB family have some more general function. This family also includes the bacterial GumN protein. The family has a conserved GXXH motif close to the N-terminus, a conserved glutamate and a conserved arginine that may be catalytic. The family also includes a second conserved GXXH motif near the C-terminus. This family also contains the Tiki proteins that regulate Wnt signalling.
Links
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Statistics
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PSSM-Id: 396512
Aligned: 196 rows
Threshold Bit Score: 80.0851
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
ADY45725      40 FLWSIESsdGAK----N-YMFGTIHVPFTEVWeHVSERVKEAFK--KANSIVFELDL-------------HNPSTIETLV 99  pig roundworm
Q82YU8        10 VEKIIVS--NKT----Y-YLVGTSHISENSVK-LVKEVIERV----QPDTVSIELDKkr----------yEKYTNSNQWG 67  Enterococcus fa...
Q82YN8         4 dIVRLFYk--GS----EiILIGTSHISAESAD-LVRKTIQE--E--NPDTICIEWDQkr----------yKKNIHPDEWD 62  Enterococcus fa...
WP_010785299   3 lVRRVFIk--DK----EiILVGTAHISSESAE-LVKNIIEE--E--NPDVVCLEWDQsr----------yDKYLNPDEWS 61  eubacteria
Q3JDP0         9 PLSIIKF--ADR----QiTLLGTAHVSRASAE-HVKALLAT--G--DYDAVAVELCPsr----------yQALINPNALS 67  Nitrosococcus o...
Q8GXY6        95 vVILTCEs-TADggscDvYLVGTAHVSKQSCL-----EVEAIISilKPEVVFVELCS----------------------S 146 thale cress
CAN73376      81 pAWRTEFv-EPE----EiWLLGTTHISS-----FSAADVERVVEvvNPDNVVVELCRs-----------rQLMTDGLIWI 139 wine grape
XP_001633823   5 tVTKLETp-EGC----VvYVIGTAHFSKESQE-DVAKTIQAV----QPDRVLVELCKsridilkydeeflLREAKNIDMQ 74  starlet sea ane...
Q9VG01       241 tVTLLNTp-FGS----KvYLVGTAHFSEESQD-DVSYVIRN--V--RPDVVMVELCPsrih------ilkLDEKTLLEEA 304 fruit fly
Q16YA2       222 tVTLLTTp-FGS----KvYLVGTAHFSENSQN-DVSLVMRN--V--QPNVVMLELCPsrvhil--kydekALLEEAKDIN 289 yellow fever mo...

ADY45725     100 K------CKNMP--T-GDDVSCYLPAKLYARLKHYIRKyrQRLASwsnrvvsnkiEAKKRarhiynsvaggweqrRPvWL 170 pig roundworm
Q82YU8        68 N------TDIIKiiK-EKKLVVLISNIVYSAYQKKLAN---T---------------------------------KGtTQ 104 Enterococcus fa...
Q82YN8        63 D------TDIVKiiK-NKQFPVFIFGVIYKLFQKKVSQ-----------------DMN--------------------SL 98  Enterococcus fa...
WP_010785299  62 D------TDIVQviK-QKRLTVLISSVIYKLIQKHLAK--------------------IN---------------DS-VA 98  eubacteria
Q3JDP0        68 R------MDLLEvlR-KGKAAMVTASLALGAYQQRIAE---QFGI------------------------------EPgAE 107 Nitrosococcus o...
Q8GXY6       147 R------LSVLK----PQTLKIPTMSDMIESWKQKQNT----FGI----------LYG--------------------WF 182 thale cress
CAN73376     140 HgrirqnCLFFL--HiAGGQTALALRLLLAVFSSKISS-----------------DVN-----------------RP--- 180 wine grape
XP_001633823  75 K------LKLAI--K-QSGVVGGIMQVLLLSMSAHITQ---QLGM------------------------------AP--- 109 starlet sea ane...
Q9VG01       305 K------SINIPkiRgILHTHGYINGIFFILLLQMSAQiaKDLGM------------------------------AP--- 345 fruit fly
Q16YA2       290 L------AKIQSivK-TNGTINGLFYILLLNMSAKITK---KLGM------------------------------AP--- 326 yellow fever mo...

ADY45725     171 LFLLYQLSEKfaQSEHi------------PM-LDLYLAQYAIESNKRLLSIETPI---EQCNPLs-S---VDREQLLFAI 230 pig roundworm
Q82YU8       105 AGELIQAIKSakEIGAn------------IQlIDRDIQVTFKRMWRHLSFLEKPK---LFMTFFt-E---FDDIEQDKLE 165 Enterococcus fa...
Q82YN8        99 VGKEFVVAVDesKKLNi-----------kFYlIDRDSSLTFKRAWRMLNFREKVKlpyAFGKIF------EGAEETEEEV 161 Enterococcus fa...
WP_010785299  99 GAEFFEAVSSaeKV-Ga-----------kIAlVDRDSQVTFKRFWRLIPLRKKAL---LPYA-Fg-SvleGAEESEEEML 161 eubacteria
Q3JDP0       108 MRAAVDSAHSakLPVLl---------------IDREVGTTLKRIYRNVPWWQRFN---LIGGLFasL---ISRDTVSEEE 166 Nitrosococcus o...
Q8GXY6       183 LAKIASHLEVfpGAEFrvayeeaikyggkVIlGDRPVQITLKRTWAKMPLWHKVK---FLYSILfqa-vfLPGAEELEKM 258 thale cress
CAN73376     181 FGDEFRAARKasEKVGa-----------qIVlGDRPIEITLERAWNSLEWNEKLS---LVISVIrg---iTSSELSTNEM 243 wine grape
XP_001633823 110 -GGEFRAAYReaRKLGc-----------qVHlGDRPIQVTLSRAMAALTVWQKVK---LAWHLL--T---TKEPISPEDV 169 starlet sea ane...
Q9VG01       346 GGEFRRAFEEihKLPGc-----------iLHlGDRPIRITLYRALRALSMWQTMK---LVWRLT------FTDSISIEEV 405 fruit fly
Q16YA2       327 GGEFRRAVDEasRIPNc-----------lIQlGDRQINITLQRALRGLSLWQTVK---LIPKLLi-----MDDDISAEEV 387 yellow fever mo...

ADY45725     231 NYTLSYLEfEQdrlskrsTDDgntgLPDLIHhyncgsleastfsldskrfnhlgfslsPDLDRKAQQIdiqlREDIIVKR 310 pig roundworm
Q82YU8       166 E----YLE----------SDS----FDKVFI----------------------------SLSKKYPSL----YQDMITDR 195 Enterococcus fa...
Q82YN8       162 Q---NLLE----------SEN----FEPVFE----------------------------ELKESYPNL----WEVFVTER 192 Enterococcus fa...
WP_010785299 162 K----LLN----------SEN----FEPIFE----------------------------QLQEAYPEL----WKVLLVER 191 eubacteria
Q3JDP0       167 VERL-----KE-------GDV----LETTFS----------------------------QFAMEAENL----YLPLIDER 198 Nitrosococcus o...
Q8GXY6       259 LKDMDNVD-----------------MVTLVI---------------------------QEMSKEFPTL----MDTIVHER 290 thale cress
CAN73376     244 K----XLStDD-------STF------QLYD----------------------------QLSVAYPSL----LQPLIHER 274 wine grape
XP_001633823 170 E---RCKQ----------KDL----LAEMLA----------------------------EMTGDFPLL----YKVFVTER 200 starlet sea ane...
Q9VG01       406 E---ECKQ----------SDL----LEKLMQ----------------------------EMAGEFPAF----SDVFVRER 436 fruit fly
Q16YA2       388 E---QCKQ----------KDL----LEEIML----------------------------EMAGEFPAF----GRVFVEER 418 yellow fever mo...

ADY45725     311 NVRMAKRIA--S--------LLr-RADtNH-----YFFALGAGHFLGENSVLELLKEHGFTIRA 358 pig roundworm
Q82YU8       196 DKYMSTKLK--N------------NSS-QV-----NVVVVGKAHMKGIK--EKLEKRTEFSLdn 237 Enterococcus faecalis
Q82YN8       193 DDYLATKIQ--N------------TAN-GK-----TVAVLGKAHLKGVSDRLKNNQKSDLqkle 236 Enterococcus faecalis
WP_010785299 192 DQYLAQKIS--D------------QEA-GK-----IVVVIGQAHLRGVE--KNLKSNQQINIke 233 eubacteria
Q3JDP0       199 DRYMAARLR--E--------EInqNEY-RH-----LLGVIGAGHLRGVTRYLEQDDATPAKKTI 246 Nitrosococcus oceani ATCC 19707
Q8GXY6       291 DQYMASSLL-----------RVasDH--SS-----VVAVIGKGHINGIKKNWKQPITMNDLMEI 336 thale cress
CAN73376     275 DTYLAWSLKrsK--------AV--NGG-KR-----VVGVIGKGHMNGV------------IYAL 310 wine grape
XP_001633823 201 DQYLARSLRlsAvp-----nIL--SNEiGGiipsvTVGVVGIGHVAGIVENFHKFEEIDIqelm 257 starlet sea anemone
Q9VG01       437 DVFLCHSLQlaAlpqaapggQQ--VRP-VR-----VVGVVGIGHANGIAKMWGTVDPKKIpail 492 fruit fly
Q16YA2       419 DLYLCHSLQvaAlpqe-lpnGL--LRP-VN-----VVGVVGIGHAAGIVKHWGKVESSAIasiv 473 yellow fever mosquito
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