1BLE


Conserved Protein Domain Family
PTS_IIB_man

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cd00001: PTS_IIB_man 
Click on image for an interactive view with Cn3D
PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family is one of four structurally and functionally distinct group IIB PTS system cytoplasmic enzymes, necessary for the uptake of carbohydrates across the cytoplasmic membrane and their phosphorylation. The active site histidine receives a phosphate group from the IIA subunit and transfers it to the substrate.
Links
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Statistics
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PSSM-Id: 237975
Aligned: 25 rows
Threshold Bit Score: 168.178
Created: 4-Sep-2001
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
 
active sitephosphorylation
Conserved site includes 3 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Comment:residues essential for phosphoryl transfer
  • Citation:PMID 9575172

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1         #   #  #                                                                    
1BLE        4 IVLARIDDRFIHGQiLTRWIKVHAADRIIVVSDDIAQDEMRKTLILSVAPs-nVKASAVSVSKMAKAFHSpryEGVTAML 82  Bacillus subtilis
1172733     6 ILLTRIDNRLVHGQvGVTWTSTIGANLLVVVDDVVANDDIQQKLMGITAEtygFGIRFFTIEKTINVIGKa-aPHQKIFL 84  Escherichia coli
NP_563548   3 IVHFRVDGRLIHGQvALAWSKMTNPNHIIVANDMVASDPNQQAILKLAAPk-qVRISMQPVDKVIAYLNRglaPNERVFL 81  Clostridium perfri...
NP_561237   3 IEFLRIDDRLLHGQvVTTWIKKYEIEQAIIVSEDVYKDKLRQTILKTAAPa-gIKVVFFNPEKFISAYHKv-pIKRRTML 80  Clostridium perfri...
NP_458163   4 IVLCRIDSRLIHGQvVTKWVGQSQANRIAVVSDELDADPFMKNIYLMAAPp-nIKVDCFGNQSFAAAWKEnqlGDGNVLV 82  Salmonella enteric...
NP_463395   2 IVFLRVDHRLLHGQvAFSWTQYVGADCILIANDSVPNDDLRKTTIKMAKPp-aVKLVIKNIADSIEAIKSgvtDKYKLFI 80  Salmonella typhimu...
14973674    3 IEFVRIDDRLVHGQvVTTWLKKYDIEQVIIVNDRISEDKTRQSILKISAPv-gLKIVFFSVKRFVEVLNSv-pIKKRTML 80  Streptococcus pneu...
NP_603528   2 ILLLRVDHRLLHGQvVFSWIQNLKADCILIANDSVATDELRKSTLKLAKPq-eIKLVIKNINDAISSINSgitDKYKLLI 80  Fusobacterium nucl...
NP_465526   2 IQFLRVDHRLLHGQvAVSWFNALDVNTILVANDGVAADDFRKSAIRLAKPe-aAKLVMKSIDESIEAINSgvtDKYNMLI 80  Listeria monocytog...
NP_459568   2 IKLVRIDYRLLHGQvVFAWTRALDIDHIIVANANAAGDAFVSMSLSLAKPa-gVSLDIITVEQAAEKLASgklDHKKVMV 80  Salmonella typhimu...
Feature 1                                                                              
1BLE       83 LFENPSDIVSLIEA-GVPIKTVNVGGMRFENHRRQITKSVSVTEQDIKAFETLSDKGVKLELRQLPSDASEDF 154 Bacillus subtilis
1172733    85 ICRTPQTVRKLVEG-GIDLKDVNVGNMHFSEGKKQISSKVYVDDQDLTDLRFIKQRGVNVFIQDVPGDQKEQI 156 Escherichia coli
NP_563548  82 LVKDVVDANRIYEG-GFKYMDLNIGNMTHKPNAKKLSEKLFVTEKEFEALKSLLDKNVNCYFQMIPTDSKQDI 153 Clostridium perfringens
NP_561237  81 LFTNPKEVFECLEG-KVKFDYLNVGNMSKTSLNEKITAGVAVTDEDRKYFKEIINSGVKVEIQMVPNDKSEDM 152 Clostridium perfringens
NP_458163  83 LFPSLAAVQDAIQL-GFDVTRIQVGGLGGGPNRKAVFQNITLDEKDVGILNDLKNRGVQVFFQTIPEDKPQPL 154 Salmonella enterica subsp...
NP_463395  81 VVESVADAYRLARE-LPDIKSINLGGTKVREGSQNIAKAINLLADEMTQLRELAAGGVEIEIRLVPNDRKQLF 152 Salmonella typhimurium LT2
14973674   81 IYTNPKDVYDSIEG-NLKLEYLNVGQMSKTEENEKVTGGVALGEEDKYYFKKIVDKGTRVEIQMVPNDKVTML 152 Streptococcus pneumoniae ...
NP_603528  81 IVESIEDAYKITKE-TNEIKQINLGGIKPRENSKNISKTINLLENEELMLKDLIKNGIEIEIRQLATDNKILY 152 Fusobacterium nucleatum s...
NP_465526  81 VVESVEDAYKLIHGtNGKIPMLNLGGTKQREGTANFSKAVNLTPEEVEKLKELQKEKVDVFMQQVPNEKKVTF 153 Listeria monocytogenes EGD-e
NP_459568  81 VLGNTAETLAFVEK-VPGISVINYGGIAQKEGAQQFGKAIYLTEQEIADSQALKAKGIRLEMRQVPAHSAELL 152 Salmonella typhimurium LT2

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