Conserved Protein Domain Family
2A0106

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TIGR00883: 2A0106 
metabolite-proton symporter
This model represents the metabolite:H+ symport subfamily of the major facilitator superfamily (pfam00083), including citrate-H+ symporters, dicarboxylate:H+ symporters, the proline/glycine-betaine transporter ProP, etc. [Transport and binding proteins, Unknown substrate]
Statistics
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PSSM-Id: 273320
Aligned: 14 rows
Threshold Bit Score: 430.156
Created: 7-Oct-2014
Updated: 25-Oct-2021
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
P44610        19 GTAIEFFDYYIYAAAAVLVFNTQFFh-SDDPLSNDLLSLSTLALAFFARPIGSALFGHFGDKIGRKKTLVASLVLMGGST 97  Haemophilus inf...
P24115        23 GNFLEQFDFFLFGFYATYIARTFFP--AESEFASLMLTFAVFGSGFLMRPVGAIVLGAYIDRIGRRKGLMVTLAIMGCGT 100 Salmonella typh...
P16482        36 GNFLEQFDFFLFGFYATYIAHTFFP--ASSEFASLMMTFAVFGAGFLMRPIGAIVLGAYIDKVGRRKGLIVTLSIMATGT 113 Klebsiella pneu...
P17448        30 GNLVEWFDFYVYSFCSLYFAHIFFP--SGNTTTQLLQTAGVFAAGFLMRPIGGWLFGRIADKHGRKKSMLLSVCMMCFGS 107 Escherichia coli
AAA90923      24 GNLVEWFDFYVYAFCAIYFAPAFFP--SDDPTVQLLNTAGVFAAGFLMRPIGGWIFGRLADRHGRKNSLMISVLMMCFGS 101 Pseudomonas putida
AAA79280      26 GHTVESHDWYVYTFLAVYFSDDIFPesSGDPLVPLLNTFAVFALAFAARPVGATVMGWYADRYGRRSALIVTILLMGLGS 105 Streptomyces hy...
P76350        30 GAVVDWYDFLLYGITAALVFNREFFp-QVSPAMGTLAAFATFGVGFLFRPLGGVIFGHFGDRLGRKRMLMLTVWMMGIAT 108 Escherichia col...
P77228         1 ------MDFQLYSLGAALVFHEIFFp-ESSTAMALILAMGTYGAGYVARIVGAFIFGKMGDRIGRKKVLFITITMMGICT 73  Escherichia col...
CAA57718      34 GNAMEWFDFGVYGFVAYALGQVFFP---GDPGVQSIAALATFSVPFLM-PLGGVFFGALGDKYGRQKILAITIIIMSIST 109 Erwinia chrysan...
WP_004596777  11 GNAAEWFDYALYAQFAYIIGQHFFP----NSSMRDTLTFAVFAAGFIVRPLGGIIFGNIGDRLGRRAALVIGIITMTVPT 86  Rickettsia prow...
P44610        98 VVIGLLPNYAQIGIWAPILLCVCRVGQGIGLGGEWGGAALVATENAPEGKRAWYGTFPQLGAPIGLFVANGTFFLVSYLL 177 Haemophilus inf...
P24115       101 LLIALVPGYQTIGLAAPALVLLGRLLQGFSAGVELGGVSVYLSEIATPGNKGFYTSWQSASQQVAIVVAALIGYSLNITL 180 Salmonella typh...
P16482       114 FLIVLIPSYQTIGLWAPLLVLIGRLLQGFSAGAELGGVSVYLAEIATPGRKGFYTSWQSGSQQVAIMVAAAMGFALNAVL 193 Klebsiella pneu...
P17448       108 LVIACLPGYETIGTWAPALLLLARLFQGLSVGGEYGTSATYMSEVAVEGRKGFYASFQYVTLIGGQLLALLVVVVLQHTM 187 Escherichia coli
AAA90923     102 LMIACLPTYGSIGTWAPALLLLARLIQGLSVGGEYGTTATYMSEVALRGQRGFFASFQYVTLIGGQLLAVLVVVILQQLL 181 Pseudomonas putida
AAA79280     106 LMIGLTPSYATAGPVAPVVLIAARLVQGFSLGGEYGAATTFLVESAAPGRRALFSSFQYVASSVGHILAGLSTLAASQ-I 184 Streptomyces hy...
P76350       109 ALIGILPSFSTIGWWAPILLVTLRAIQGFAVGGEWGGAALLSVESAPKNKKAFYSSGVQVGYGVGLLLSTGLVSLISMMT 188 Escherichia col...
P77228        74 TLIGVLPTYAQIGVFAPILLVTLRIIQGLGAGAEISGAGTMLAEYAPKGKRGIISSFVAMGTNCGTLSATAIWAFMFFIL 153 Escherichia col...
CAA57718     110 FCIGLIPSYERIGIWAPILLLLAKMAQGFSVGGEYTGASIFVAEYSPDRKRGFMGSWLDFGSIAGFVLGAGVVVLISTLI 189 Erwinia chrysan...
WP_004596777  87 AGIGLLPSYNTIGIAAPIILTIIRLIQGFSLGGEFSGCISYIVEHAAIEKRGLAGSASFVSMCGGMLLGLLTASGFSYFM 166 Rickettsia prow...
P44610       178 GHNALVEWAWRIPFVSSILLVAVGLYVRLTLHESHVFVEAeqKGKkl---------naPVSVVFTKHLKPMVIGTFIMVA 248 Haemophilus inf...
P24115       181 GHDAISEWGWRIPFFIGCMIIPLIFVLRRSLQETEAFLQR--KHRpd---------trEIFATIAKNWRIITAGTLLVAM 249 Salmonella typh...
P16482       194 EPSAISDWGWRIPFLFGVLIVPFIFILRRKLEETQEFTAR--RHHla---------mrQVFATLLANWQVVIAGMMMVAM 262 Klebsiella pneu...
P17448       188 EDAALREWGWRIPFALGAVLAVVALWLRRQLDETSQQET---RALke---------agSLKGLWRNRR-AFIMVLGFTAA 254 Escherichia coli
AAA90923     182 TEDELRAWGWRIPFVVGAIAALISLMLRRSLHETSSAET---RNDkd---------agTIKGLFRNHAAAFITVLGYTAG 249 Pseudomonas putida
AAA79280     185 SGDGMDRWGWRLPFIWGAVICLAGLALRSTAEETLPTGTEggRKKtr---------tgAFAALRSHPR-QTLLVVGLTIG 254 Streptomyces hy...
P76350       189 TDEQFLSWGWRIPFLFSIVLVLGALWVRNGMEESAEFEQQqhYQAaak-------kriPVIEALLRHPGAFLKIIALRLC 261 Escherichia col...
P77228       154 SKEELLAWGWRIPFLASVVVMVFAIWLRMNLKESPVFEKVndSNQpta-------kpaPAGSMFQSKS--FWLATGLRFG 224 Escherichia col...
CAA57718     190 GEQAFLAWGWRLPFFLALPLGLIGLYL-ATLEETPAFRQHveKLEqndrdglkagpgvSFREIATHHWKSLLVCIGLVIA 268 Erwinia chrysan...
WP_004596777 167 SDDILFEWGWRVPFIVGLFIGSIGLYIRKNLAESPIYKKAkeRGRla---------rfPLRETLTQYPKELMIALGLYIT 237 Rickettsia prow...
P44610       249 TYSLFYIMTAFAQAYSRTAPKlseagyalglgIPANTFTGLLLISAIVFGIFISISGFYADKIGRRKWLIWVTIAIGVLG 328 Haemophilus inf...
P24115       250 TTTTFYFITVYTPTYGRTVLN-----------LSARDSLIVTMLVGVSNFIWLPIGGAISDRIGRRAVLMGITLLALITT 318 Salmonella typh...
P16482       263 TTTAFYLITVYAPTFGKKVLM-----------LSASDSLLVTLLVAISNFFWLPVGGALSDRFGRRSVLIAMTLLALATA 331 Klebsiella pneu...
P17448       255 GSLCFYTFTTYMQKYLVNTAG-----------MHANVASGIMTAALFVFMLIQPLIGALSDKIGRRTSMLCFGSLAAIFT 323 Escherichia coli
AAA90923     250 GSLIFYTFTTYMQKYLVNTAG-----------MTAKNASYVMTGALFLFMVVQPFFGMLSDRIGRRNSMLLFGALGTLCT 318 Pseudomonas putida
AAA79280     255 GNVAFYTWTTYLPTYATVSTG-----------ADKDSAVLAGTVSLIFFGLIQPLGGLLCERIGGRAMMIGFGVAAAVLT 323 Streptomyces hy...
P76350       262 ELLTMYIVTAFALNYSTQNm-----------gLPRELFLNIGLLVGGLSCLTIPCFAWLADRFGRRRVYITGTLIGTLSA 330 Escherichia col...
P77228       225 QAGNSGLIQTFLAGYLVQTl-----------lFNKAIPTDALMISSILGFMTIPFLGWLSDKIGRRIPYIIMNTSAIVLA 293 Escherichia col...
CAA57718     269 TNVTYYMLLTYMPSYLSHSLH-----------YSENHGVLIIIAIMIGMLFVQPVMGLLSDRFGRKPFVVIGSVAMFFLA 337 Erwinia chrysan...
WP_004596777 238 VTAPFYTLTVFIGNFM-QTLG-----------YSNQQSTIVNSIILIVMMIVFPISAYVSDKVGRRPVLICAIILLILLV 305 Rickettsia prow...
P44610       329 -LAMPLFLENGt-PVSVFAFLVIGMAIMG-MTFGPMAALLPELFPTEVRYSGASLAYNLASIIGATIAAMISLKINASFG 405 Haemophilus inf...
P24115       319 wPVMQWLTAAP--DFTRMTLVLLWFSFFFgMYNGAMVAALTEVMPVYVRTVGFSLAFSLATAIFGGLTPAISTALVKLTG 396 Salmonella typh...
P16482       332 wPALTMLANAP--SFLMMLSVLLWLSFIYgMYNGAMIPALTEIMPAEVRVAGFSLAYSLATAVFGGFTPVISTALIEYTG 409 Klebsiella pneu...
P17448       324 vPILSALQNVS--SPYAAFGLVMCALLIVsFYTSISGILKAEMFPAQVRALGVGLSYAVANAIFGGSAEYVALSLKSIGM 401 Escherichia coli
AAA90923     319 vPLLMALKTVT--SPFMAFVLISLALCIVsFYTSISGLVKAEMFPPQVRALGVGLAYAVANAAFGGSAEYVALGLKTLGM 396 Pseudomonas putida
AAA79280     324 vPLLTAMT--G--WFWSVLAVQCAGMLVLtAYTSVSGAINAELFPQELRGRGIGLPYAASVALFGGTAPYVGTWLKSMGL 399 Streptomyces hy...
P76350       331 fPFFMALEAQS--IFWIVFFSIMLANIAHdMVVCVQQPMFTEMFGASYRYSGAGVGYQVASVVGGGFTPFIAAALITYFA 408 Escherichia col...
P77228       294 wPMLSIIVDKSyaPSTIMVALIVIHNCAVlGLFALENITMAEMFGCKNRFTRMAISKEIGGLIASGFGPILAGIFCTMTE 373 Escherichia col...
CAA57718     338 vPSFM-LINSD--IIGLIFLGLLMLAVILnAFTGVMASTLPALFPTHIRYSALASAFNISVLI-AGLTPTVAAWLVESSQ 413 Erwinia chrysan...
WP_004596777 306 yPIFVAL-GSM--NITLAIISQVIFAGIIaTYMGPIPTVLVEIFPTRVRFTGVALSYNLAAAIFGGTAPMVAMILTRITG 382 Rickettsia prow...
P44610       406 --VMGVGIYLAINALMTF 421 Haemophilus influenzae Rd KW20
P24115       397 d-KSSPGWWLMCAALCGL 413 Salmonella typhimurium
P16482       410 d-KASPGYWMSFAAICGL 426 Klebsiella pneumoniae
P17448       402 e-TAFFWYVTLMAVVAFL 418 Escherichia coli
AAA90923     397 e-NTFYWYVTAMMAIAFL 413 Pseudomonas putida
AAA79280     400 n-DFFPWYVAVLCLLTAL 416 Streptomyces hygroscopicus
P76350       409 gnWHSVAIYLLAGCLISA 426 Escherichia coli K-12
P77228       374 s-WYPIAIMIMAYSVIGL 390 Escherichia coli K-12
CAA57718     414 n-LYMPAYYLMVIAVIGL 430 Erwinia chrysanthemi
WP_004596777 383 d-NYAISYYLIALSLLSs 399 Rickettsia prowazekii
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