?cl40727: CagE_TrbE_VirB Superfamily (this model, PSSM-Id:424358 is obsolete and has been replaced by 454818)
CagE, TrbE, VirB family, component of type IV transporter system This family includes the Helicobacter pylori protein CagE, which together with other proteins from the cag pathogenicity island (PAI), encodes a type IV transporter secretion system. The precise role of CagE is not known, but studies in animal models have shown that it is essential for pathogenesis in Helicobacter pylori induced gastritis and peptic ulceration. Indeed, the expression of the cag PAI has been shown to be essential for stimulating human gastric epithelial cell apoptosis in vitro. Similar type IV transport systems are also found in other bacteria. This family includes the TrbE and VirB proteins from the respective trb and Vir conjugal transfer systems in Agrobacterium tumefaciens. homologs of VirB proteins from other species are also members of this family, e.g. VirB from Brucella suis. |
Jiyao W et al.(2023). "The conserved domain database in 2023.",