Conserved Protein Domain Family
FtsH_fam

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TIGR01241: FtsH_fam 
ATP-dependent metalloprotease FtsH
HflB(FtsH) is a pleiotropic protein required for correct cell division in bacteria. It has ATP-dependent zinc metalloprotease activity. It was formerly designated cell division protein FtsH. [Cellular processes, Cell division, Protein fate, Degradation of proteins, peptides, and glycopeptides]
Statistics
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PSSM-Id: 273520
Aligned: 17 rows
Threshold Bit Score: 769.144
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
P72991   107 FWFRIASTLFLpILLLVGIFFLFRRAQSGP----Gs-------qAMNFGKSKARVQMEP-QTQVTFGDVAGIEQAKLELT 174 Synechocystis sp. P...
O83746    84 YLIETFQYLFP-LLILFFVWRFFFKRMASNvsglGs-------sIFSAGHARSAAVEEG-KVTTRFADVAGVDEAKEELM 154 Treponema pallidum ...
P71408   117 FFTDMLGWLMP-ILVILGLWMFMANRMQKNm---Gg-------gIFGMGSAKKLINAE--KPNVRFNDMAGNEEAKEEVV 183 Helicobacter pylori...
P75120   171 DVLNIFFGLLP-IIIFVIFFLLFWRSARGI----SgggrseednIFSIGKTQAKLAKS----SVRFDNIAGLQEEKHELL 241 Mycoplasma pneumoni...
P47695   175 DVLNGLFGLLP-IIIFVVFFLLFWRSARGI----Saggr-eednIFSIGKTQAKLAKS----TVKFTNIAGLQEEKHELL 244 Mycoplasma genitali...
O67077   100 WLVNVFLSWLP-ILFFIGIWIFLLRQMSGG----Gnv-----nrAFNFGKSRAKVYIEE-KPKVTFKDVAGIEEVKEEVK 168 Aquifex aeolicus VF5
Q55700   116 MVWGFVGNLIFpVLLIASLFFLFRRSSNMP----Ggp-----gqAMNFGKSKARFQMDA-KTGVMFDDVAGIDEAKEELQ 185 Synechocystis sp. P...
P96942   110 SILGELLVYVLpLLLLVGLFVMFSRMQGGA----Rm--------GFGFGKSRAKQLSKD-MPKTTFADVAGVDEAVEELY 176 Mycobacterium tuber...
P37476   108 GWVTFLTTIIPfVIIFILFFFLLNQAQGGG----Sr--------VMNFGKSKAKLYTEE-KKRVKFKDVAGADEEKQELV 174 Bacillus subtilis s...
AAA62606 290 NWAKAMFQILPtVLMIAGIIWLTRRSAQAA----Ggsr----ggIFGLSRSKAKKFNTEtDVKIKFKDVAGCDEAKEEIM 361 baker's yeast
P72991   175 EVVDFLKNADRFTELGAKIPKGVLLVGPPGTGKTLLAKAVAGEAGVPFFSISGSEFVEMFVGVGASRVRDLFEQAKANAP 254 Synechocystis sp. P...
O83746   155 EVVDFLKFPKKYTEIGGKIPRGVLLVGPPGTGKTLLARAVAGEASVPFFRISGSDFIEMFVGIGASRVRDLFKQAREKAP 234 Treponema pallidum ...
P71408   184 EIVDFLKYPERYANLGAKIPKGVLLVGPPGTGKTLLAKAVAGEAHVPFFSMGGSSFIEMFVGLGASRVRDLFETAKKQAP 263 Helicobacter pylori...
P75120   242 EIVDYLKNPLKYAQMGARSPRGVILYGPPGTGKTLLAKAVAGEAGVPFFQSTGSGFEDMLVGVGAKRVRDLFNKAKKAAP 321 Mycoplasma pneumoni...
P47695   245 EIVDYLKNPLKYAQMGARSPRGVILYGPPGTGKTLLAKAVAGEAGVPFFQSTGSGFEDMLVGVGAKRVRDLFNKAKKAAP 324 Mycoplasma genitali...
O67077   169 EIIEYLKDPVKFQKLGGRPPKGVLLYGEPGVGKTLLAKAIAGEAHVPFISVSGSDFVEMFVGVGAARVRDLFETAKKHAP 248 Aquifex aeolicus VF5
Q55700   186 EVVTFLKQPERFTAVGAKIPKGVLLVGPPGTGKTLLAKAIAGEAGVPFFSISGSEFVEMFVGVGASRVRDLFKKAKENAP 265 Synechocystis sp. P...
P96942   177 EIKDFLQNPSRYQALGAKIPKGVLLYGPPGTGKTLLARAVAGEAGVPFFTISGSDFVEMFVGVGASRVRDLFEQAKQNSP 256 Mycobacterium tuber...
P37476   175 EVVEFLKDPRKFAELGARIPKGVLLVGPPGTGKTLLAKACAGEAGVPFFSISGSDFVEMFVGVGASRVRDLFENAKKNAP 254 Bacillus subtilis s...
AAA62606 362 EFVSFLKEPSRYEKMGAKIPRGAILSGPPGTGKTLLAKATAGEAGVPFYFVSGSEFVEMFVGVGAARVRDLFKTARENAP 441 baker's yeast
P72991   255 CIVFIDEIDAVGRQRGAg-LGGGNDEREQTLNQLLTEMDGFEGNTG-IIIVAATNRPDVLDSALMRPGRFDRQVVVDRPD 332 Synechocystis sp. P...
O83746   235 GIIFIDELDAIGKSRLN--AIHSNDEREQTLNQLLVEMDGFDNTTG-LILLAATNRPDVLDPALLRPGRFDRQVCVDRPD 311 Treponema pallidum ...
P71408   264 SIIFIDEIDAIGKSRAAggVVSGNDEREQTLNQLLAEMDGFGSENApVIVLAATNRPEILDPALMRPGRFDRQVLVDKPD 343 Helicobacter pylori...
P75120   322 CIIFIDEIDSVGSKRGRveLSS-YSVVEQTLNQLLAEMDGFTSRTG-VVVMAATNRLDVLDDALLRPGRFDRHIQINLPD 399 Mycoplasma pneumoni...
P47695   325 CIIFIDEIDSVGSKRGRveLSS-YSVVEQTLNQLLAEMDGFTSRTG-VVVMAATNRLDVLDDALLRPGRFDRHIQINLPD 402 Mycoplasma genitali...
O67077   249 CIIFIDEIDAVGRARGAipVGGGHDEREQTLNQLLVEMDGFDTSDG-IIVIAATNRPDILDPALLRPGRFDRQIFIPKPD 327 Aquifex aeolicus VF5
Q55700   266 CLIFIDEIDAVGRQRGAg-IGGGNDEREQTLNQLLTEMDGFEGNTG-IIIIAATNRPDVLDSALMRPGRFDRQVMVDAPD 343 Synechocystis sp. P...
P96942   257 CIIFVDEIDAVGRQRGAg-LGGGHDEREQTLNQLLVEMDGFGDRAG-VILIAATNRPDILDPALLRPGRFDRQIPVSNPD 334 Mycobacterium tuber...
P37476   255 CLIFIDEIDAVGRQRGAg-LGGGHDEREQTLNQLLVEMDGFSANEG-IIIIAATNRADILDPALLRPGRFDRQITVDRPD 332 Bacillus subtilis s...
AAA62606 442 SIVFIDEIDAIGKARQKgnFSGANDERENTLNQMLVEMDGFTPADH-VVVLAGTNRPDILDKALLRPGRFDRHINIDKPE 520 baker's yeast
P72991   333 YAGRREILNVHARGKTLS-QDVDLD-KIARRTPGFTGADLSNLLNEAAILAARRNLTEISMDEVNDAIDRVLAGPEKKNR 410 Synechocystis sp. P...
O83746   312 LKGREAILRIHAQNVKLA-PEVDLK-AVARITGGYSGADLANVVNEAALLAVRSGRAQVIETDLDEAVEKTMIGLQKKSR 389 Treponema pallidum ...
P71408   344 FNGRVEILKVHIKGVKLA-NDVNLQ-EVAKLTAGLAGADLANIINEAALLAGRNNQKEVRQQHLKEAVERGIAGLEKKSR 421 Helicobacter pylori...
P75120   400 IKEREGILQVHAKNKNLS-SKISLL-DVAKRTPGFSGAQLENVINEATLLAVRDNRTTINMNDIDEAIDRVIAGPAKKSR 477 Mycoplasma pneumoni...
P47695   403 IKEREGILKVHAENKNLS-SKISLL-DVAKRTPGFSGAQLENVINEATLLAVRDNRTTININDIDEAIDRVIAGPAKKSR 480 Mycoplasma genitali...
O67077   328 VRGRYEILKVHARNKKLA-KDVDLE-FVARATPGFTGADLENLLNEAALLAARKGKEEITMEEIEEALDRITMGLERKGM 405 Aquifex aeolicus VF5
Q55700   344 YSGRKEILEVHARNKKLA-PEVSID-SIARRTPGFSGADLANLLNEAAILTARRRKSAITLLEIDDAVDRVVAGMEGTPL 421 Synechocystis sp. P...
P96942   335 LAGRRAVLRVHSKGKPMA-ADADLD-GLAKRTVGMTGADLANVINEAALLTARENGTVITGPALEEAVDRVIGGPRRKGR 412 Mycobacterium tuber...
P37476   333 VIGREAVLKVHARNKPLD-ETVNLK-SIAMRTPGFSGADLENLLNEAALVAARQNKKKIDARDIDEATDRVIAGPAKKSR 410 Bacillus subtilis s...
AAA62606 521 LEGRKAIFAVHLHHLKLAgEIFDLKnRLAALTPGFSGADIANVCNEAALIAARSDEDAVKLNHFEQAIERVIGGVERKSK 600 baker's yeast
P72991   411 VMSEKRKTLVAYHEAGHALVGALMPDYDPVQKISIIPRGR-AGGLTWFTPSEdrmESGLYSRSYLQNQMAVALGGRIAEE 489 Synechocystis sp. P...
O83746   390 VIREEERRIIAYHETGHALAGTFTKGADKVHKITIIPRGTsALGYTFHIPED---DRHIVTEQQLLAEVDVLLSGRAAEF 466 Treponema pallidum ...
P71408   422 RISPKEKKIVAYHESGHAVISEMTKGSARVNKVSIIPRGMaALGYTLNTPEE---NKYLMQKHELIAEIDVLLGGRAAED 498 Helicobacter pylori...
P75120   478 VVSDADRKLVAYHEAGHALVGLHVHSNDEVQKITIIPRGQ-AGGYTLSTPKSg--DLNLKRKSDLLAMIATAMGGRAAEE 554 Mycoplasma pneumoni...
P47695   481 VISDEDRKLVAYHEAGHALVGLHVHSNDEVQKITIIPRGQ-AGGYTLSTPKSg--DLNLKRKSDLLAMIATAMGGRAAEE 557 Mycoplasma genitali...
O67077   406 TISPKEKEKIAIHEAGHALMGLVSDDDDKVHKISIIPRGM-ALGVTQQLPIE---DKHIYDKKDLYNKILVLLGGRAAEE 481 Aquifex aeolicus VF5
Q55700   422 VDS-KSKRLIAYHEVGHAIVGTLLKDHDPVQKVTLIPRGQ-AQGLTWFTPNE---EQGLTTKAQLMARIAGAMGGRAAEE 496 Synechocystis sp. P...
P96942   413 IISEQEKKITAYHEGGHTLAAWAMPDIEPIYKVTILARGR-TGGHAVAVPEE---DKGLRTRSEMIAQLVFAMGGRAAEE 488 Mycobacterium tuber...
P37476   411 VISKKERNIVAYHEGGHTVIGLVLDEADMVHKVTIVPRGQ-AGGYAVMLPRE---DRYFQTKPELLDKIVGLLGGRVAEE 486 Bacillus subtilis s...
AAA62606 601 LLSPEEKKVVAYHEAGHAVCGWYLKYADPLLKVSIIPRGQgALGYAQYLPGD----VFLLTEQQLKDRMTMSLGGRVSEE 676 baker's yeast
P72991   490 IIFGeeEVTTGASNDLQQVARVARQMVTRFGMSDRLGPVALGr-QGGGVFLGRDiASDRDFSDETAAAIDEEVSQLVDQA 568 Synechocystis sp. P...
O83746   467 VAFG--EVSTGAGNDISRATDIVRKMITDYGMSEKFQNVALT--RRGTGYLAEP-QLAREYSECTQQYVDEEVARVLAER 541 Treponema pallidum ...
P71408   499 VFLE--EISTGASNDLERATDIIKGMVSYYGMSSVSGLMVLE--KQRNAFLGGGyGSSREFSEKTAEEMDLFIKNLLEER 574 Helicobacter pylori...
P75120   555 EIYGplEITTGASSDFYKATNIARAMVTQLGMSK-LGQVQYVpsQG--TVPPG----TKLFSEQTAKDIDFEINAIIEEQ 627 Mycoplasma pneumoni...
P47695   558 EIYGnlEITTGASSDFYKATNIARAMVTQLGMSK-LGQVQYVpsQG--TLPSN----VKLYSEQTAKDIDNEINFIIEEQ 630 Mycoplasma genitali...
O67077   482 VFFGkdGITTGAENDLQRATDLAYRMVSMWGMSDKVGPIAIRr-VANPFLGGMT--TAVDTSPDLLREIDEEVKRIITEQ 558 Aquifex aeolicus VF5
Q55700   497 EVFGddEVTTGAGGDLQQVTEMARQMVTRFGMSN-LGPISLEs-SGGEVFLGGGlMNRSEYSEEVATRIDAQVRQLAEQG 574 Synechocystis sp. P...
P96942   489 LVFR--EPTTGAVSDIEQATKIARSMVTEFGMSSKLGAVKYGs-EHGDPFLGRTmGTQPDYSHEVAREIDEEVRKLIEAA 565 Mycobacterium tuber...
P37476   487 IIFG--EVSTGAHNDFQRATNIARRMVTEFGMSEKLGPLQFGqsQGGQVFLGRDfNNEQNYSDQIAYEIDQEIQRIIKEC 564 Bacillus subtilis s...
AAA62606 677 LHFP--SVTSGASDDFKKVTSMATAMVTELGMSDKIGWVNYQkrD--------DsDLTKPFSDETGDIIDSEVYRIVQEC 746 baker's yeast
P72991   569 YQRAKQVLVENRGILDQLAEILVEKETVDSEELQTLLA 606 Synechocystis sp. PCC 6803 substr. Kazusa
O83746   542 YRAVVALLTEKKELLEYIATRLLERETIERDEFEEVIR 579 Treponema pallidum subsp. pallidum str. Nichols
P71408   575 YKHVKQTLSDYREAIEIMVKELFDKEVITGERVREIIS 612 Helicobacter pylori 26695
P75120   628 YKKARTIIKTNRKELELLVEALLIAETILKSDIDYIHE 665 Mycoplasma pneumoniae M129
P47695   631 YKKAKTIIKSNRKELELLVEALLIAETILKSDIDFIHK 668 Mycoplasma genitalium G37
O67077   559 YEKAKAIVEEYKEPLKAVVKKLLEKETITCEEFVEVFK 596 Aquifex aeolicus VF5
Q55700   575 HQMARKIVQEQREVVDRLVDLLIEKETIDGEEFRQIVA 612 Synechocystis sp. PCC 6803 substr. Kazusa
P96942   566 HTEAWEILTEYRDVLDTLAGELLEKETLHRPELESIFA 603 Mycobacterium tuberculosis
P37476   565 YERAKQILTENRDKLELIAQTLLKVETLDAEQIKHLID 602 Bacillus subtilis subsp. subtilis str. 168
AAA62606 747 HDRCTKLLKEKAEDVEKIAQVLLKKEVLTREDMIDLLG 784 baker's yeast
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