4HI0


Conserved Protein Domain Family
UreG

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cd05540: UreG 
Click on image for an interactive view with Cn3D
urease accessory protein UreG
UreG is one of the four accessory proteins of urease. Urease is an enzyme which catalyzes the decomposition of urea to form ammonia and carbon dioxide. Bacterial urease is a trimer of three subunits which are encoded by genes ureA, ureB, and ureC. Up to four accessory proteins (ureD, ureE, ureF, and ureG) are required for urease catalytical function. UreG may play an important role in nickel incorporation of the urease metallocenter. UreG is a member of the Fer4_NifH superfamily which contains an ATP-binding domain. Proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion.
Statistics
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PSSM-Id: 349776
Aligned: 25 rows
Threshold Bit Score: 314.972
Created: 17-Sep-2007
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 16 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Comment:The active site is located in dimer interface
  • Structure:4HI0; Helicobacter pylori UreG with bound GDP, contacts at 4A

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1            ########                     #                                           
4HI0_E      2 VKIGVCGPVGSGKTALIEALTRHMskd-ydMAVITNDIYTKEDAEFMckn-----svMPRERIIGVETGGCPHTAIREDA 75  Helicobacter pylor...
AAN76660    8 LRVGIGGPVGSGKTALCEVLSKKMrdr-yeMAVITNDIYTKEDMEILlra-----eaLPAERLMGVETGGCPHTAIREDA 81  Nitrosospira sp. NpAV
NP_285635   4 LKIGVGGPVGSGKTALLEVLCRELrdr-ydLAVITNDIYTFEDQRILtra-----aaLAPERIRGVQTGGCPHTAIREDS 77  Deinococcus radiod...
Q03287      8 LRIGVGGPVGSGKTALLEVLCKAMrdt-yqIAVVTNDIYTQEDAKILtra-----eaLDADRIIGVETGGCPHTAIREDA 81  Escherichia coli
ABK77085    5 PRVGIGGPVGAGKSMLIERVVPVLaargyhVSIVSNDVISKEDADRMraslaterglLPEDLVVGVATGGCPHTAVREDP 84  Cenarchaeum symbio...
NP_216368  26 LRIGVGGPVGSGKTALVAALCRQLrge-lsLAVLTNDIYTTEDADFLrth-----avLPDDRIAAVQTGGCPHTAIRDDI 99  Mycobacterium tube...
Q8DMQ4      5 LRVGVAGPVGSGKTALVDALCKALrdr-yrLAVVTNDIYTQEDAQFLvrs-----qaLPPERILGVETGGCPHTAIREDA 78  Thermosynechococcu...
A9KJR6      4 IKIGVGGPVGAGKTMLVEKLTRYMsdd-ysMAVVTNDIYTKEDAKFLmen-----gvLPSDRIIGVETGGCPHTAIREDA 77  Clostridium phytof...
Q98CZ5      8 LRIGIGGPVGSGKTTLTEKLCKALrde-fsIAVVTNDIYTREDAMMLarl-----qaLPEDRIVGVETGGCPHTAIREDA 81  Mesorhizobium loti
B1ZNZ7      9 PRVGIGGPVGSGKTMLCLKLCQRLrer-lsMAVVTNDIYCSEDAQFLirq-----saLPAARIAGVETGGCPHTAIRDDT 82  Opitutus terrae
Feature 1                           #                                              ## #       
4HI0_E     76 SMNLEAVEEMhgrfpnlELLLIESGGDNLSATFNPELADFTIFVIDVAEGDKIPRKGGPGITRSDLLVINKIDLAPYVGA 155 Helicobacter pylor...
AAN76660   82 SINLEAIARMtadfpnlDLILVESGGDNLASTFSPELSDLTIYVIDVAAGEKIPRKGGPGITRSALLVINKIDLAPYVGA 161 Nitrosospira sp. NpAV
NP_285635  78 SLNQETVEALqgefpglELLFIESGGDNLASSFSPELVDAWLFVLDVAGGEKVPRKGGPGIRHSDLLVINKTDLAPLVGA 157 Deinococcus radiod...
Q03287     82 SMNLAAVEELairhknlDIVFVESGGDNLSATFSPELADLTIYVIDVAEGEKIPRKGGPGITHSDLLVINKIDLAPYVGA 161 Escherichia coli
ABK77085   85 SMNISIIEEIeaghpelDLVIIESGGDNITTTFSPALADYFIYMIDVAGGDKYPRKGGLGIESCDLLLINKTDLAGMVGA 164 Cenarchaeum symbio...
NP_216368 100 TANLDAIDELmaahdalDLILVESGGDNLTATFSSGLVDAQIFVIDVAGGDKVPRKGGPGVTYSDLLVVNKTDLAALVGA 179 Mycobacterium tube...
Q8DMQ4     79 SLNLAAIQQLetafrplDLIFVESGGDNLAATFSPELVDLTIYVIDVAAGDKIPRKGGPGITKSDLLVINKIDLAPYVGA 158 Thermosynechococcu...
A9KJR6     78 SMNFAAVNELvqrhpdvQIVFVESGGDNLAATFSPELADFSIYIIDVAQGEKIPRKGGQGMIKSDLFVINKTDLAPYVGA 157 Clostridium phytof...
Q98CZ5     82 SINLQAIAELnrkfpdlDIIFIESGGDNLAATFSPDLADLTLYVISVCQGEEIPRKGGPAITRSDFLIINKSDLAPYVNV 161 Mesorhizobium loti
B1ZNZ7     83 TMNEQACRALeatfpelDLLLVESGGDNLTATFSPELVDAFIYVIDVAEGDKIPRKGGPAIRFSDLLIINKVDLAPLVGA 162 Opitutus terrae
Feature 1                          ###             
4HI0_E    156 DLKVMERDSKKMRGEKPFIFTNIRaKEGLDDVIAWIK 192 Helicobacter pylori G27
AAN76660  162 NLEVMARDAKRMRGERPFVFTNLHtGEGVEQIIEFIV 198 Nitrosospira sp. NpAV
NP_285635 158 DLRVMDADARAQRRAGDEVRPYVFtNLKSGAGVDEII 194 Deinococcus radiodurans R1
Q03287    162 SLEVMEADTARMRPVKPYVFTNLKkKVGLETIIEFII 198 Escherichia coli
ABK77085  165 DLGVMRADAERIRGERPFGFVNCMtDEGITEVAERII 201 Cenarchaeum symbiosum A
NP_216368 180 DLAVMARDADAVRDGRPTVLQSLTeDPAASDVVAWVR 216 Mycobacterium tuberculosis H37Rv
Q8DMQ4    159 DLEVMKRDTLKMRGDRPYVMTNLKtGLGLDQVIAFLT 195 Thermosynechococcus elongatus BP-1
A9KJR6    158 NLDIMASDTRKFRGNKPFVFTNLKkDEGLPDVISWIR 194 Clostridium phytofermentans
Q98CZ5    162 NLDVMESDAARMRGKRPFGFTDLSrGKGLREVIDFIV 198 Mesorhizobium loti
B1ZNZ7    163 DLEVMARDATAQRGGRPFLLCDLKrEHNLDAVIGWLE 199 Opitutus terrae

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