1KO9


Conserved Protein Domain Family
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TIGR00588: ogg 
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8-oxoguanine DNA-glycosylase (ogg)
All proteins in this family for which functions are known are 8-oxo-guanaine DNA glycosylases that function in base excision repair. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). This family is distantly realted to the Nth-MutY superfamily. [DNA metabolism, DNA replication, recombination, and repair]
Statistics
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PSSM-Id: 211589
Aligned: 7 rows
Threshold Bit Score: 450.132
Created: 7-Oct-2014
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1KO9_A    11 MGHRtlastpalWASIPCPRSELRLDLVLPSGQSFRWR-EQSPAHWSG--VLADQ----VWTLTQTEE-QLHCTVYRGDK 82  human
CAA72117  11 MRHRtlssspalWASIPCPRSELRLDLVLASGQSFRWK-EQSPAHWSG--VLADQ----VWTLTQTED-QLYCTVYRGDD 82  house mouse
AAC77525  11 MRHRtltsspalWASIPCPRSELRLDLVLASGQSFRWR-EQSPAHWSG--VLADQ----VWTLTQTED-QLYCTVYRGDK 82  Norway rat
AAB84013   1 MGHRtlastpalWASIPCPRSELRLDLVLPSGQSFRWR-EQSPAHWSG--VLADQ----VWTLTQTEE-QLHCTVYRGDK 72  human
P53397     1 MSYK--------FGKLAINKSELCLANVLQAGQSFRWIwDEKLNQYSTtmKIGQQekysVVILRQDEEnEILEFVAVGDC 72  Saccharomyces cerev...
O27397     1 ---------------MRIPVGDFDLEMTQRSGQTSQPPwREVEGAFREllIIEGVp---CPVEVRNEA-GVLRVRPYVDV 61  Methanothermobacter...
AAB68615  11 MGHRtlastpalWASIPCPRSELRLDLVLPSGQSFRWR-EQSPAHWSG--VLADQ----VWTLTQTEE-QLHCTVYRGDK 82  human
1KO9_A    83 sqasrP-----TPDELEA-VRKYFQLDVTLAQLYHH-WGSVDSHFQEVAQKFQGVRLLRQ-DPIECLFSFICSSNNNIAR 154 human
CAA72117  83 -----SqvsrpTLEELET-LHKYFQLDVSLAQLYSH-WASVDSHFQRVAQKFQGVRLLRQ-DPTECLFSFICSSNNNIAR 154 house mouse
AAC77525  83 -----GqvgrpTLEELET-LHKYFQLDVSLTQLYSH-WASVDSHFQSVAQKFQGVRLLRQ-DPTECLFSFICSSNNNIAR 154 Norway rat
AAB84013  73 -----SqasrpTPDELEA-VRKYFQLDVTLAQLYHH-WGSVDYHFQEVAQKFQGVRLLRQ-DPIECLFSFICSSNNNIAR 144 human
P53397    73 -----G-----NQDALKThLMKYFRLDVSLKHLFDNvWIPSDKAFAKLSP--QGIRILAQ-EPWETLISFICSSNNNISR 139 Saccharomyces cerev...
O27397    62 -----P------QKTLREkIEYIFDLKFDIEDFYTF---LEDKNLSYTLDSSRGLRLFLAkDPFECVISSIASANCSVVR 127 Methanothermobacter...
AAB68615  83 -----SqasrpTPDELEA-VRKYFQLDVTLAQLYHH-WGSVDSHFQEVAQKFQGVRLLRQ-DPIECLFSFICSSNNNIAR 154 human
1KO9_A   155 ITGMVERLCQAFGPRLIQLDDVTYHGFPSLQALAG---------PEVEA---------HLRKLGLGYRARYVSASARAIL 216 human
CAA72117 155 ITGMVERLCQAFGPRLIQLDDVTYHGFPNLHALAG---------PEAET---------HLRKLGLGYRARYVRASAKAIL 216 house mouse
AAC77525 155 ITGMVERLCQAFGPRLVQLDDVTYHGFPNLHALAG---------PEVET---------HLRKLGLGYRARYVCASAKAIL 216 Norway rat
AAB84013 145 ITGMVERLCQAFGPRLIQLDDVTYHGFPSLQALAG---------PEVEA---------HLRKLGLGYRARYVSASARAIL 206 human
P53397   140 ITRMCNSLCSNFGNLITTIDGVAYHSFPTSEELTS---------RATEA---------KLRELGFGYRAKYIIETARKLV 201 Saccharomyces cerev...
O27397   128 WTRSIEDIRRLWG-QANTFNGETFHTFPSPHVLTGvaegsledlQRAEDnlpsdfsfnDLRSCGVGYRAPYIRETSRILA 206 Methanothermobacter...
AAB68615 155 ITGMVERLCQAFGPRLIQLDDVTYHGFPSLQALAG---------PEVEA---------HLRKLGLGYRARYVSASARAIL 216 human
1KO9_A   217 EEQGGL------AWLQQL-RESSYEEAHKALCILPGVGTKVADCICLMALDKPQAVPVDVHMWHIAQRDYSW-----HPT 284 human
CAA72117 217 EEQGGP------AWLQQL-RVAPYEEAHKALCTLPGVGAKVADCICLMALDKPQAVPVDVHVWQIAHRDYGW-----HPK 284 house mouse
AAC77525 217 EEQGGP------AWLQQL-RVASYEEAHKALCTLPGVGTKVADCICLMALDKPQAVPVDIHVWQIAHRDYGW-----QPK 284 Norway rat
AAB84013 207 EEQGGL------AWLQQL-PQSSYEEAHKALCILPGVGTKVADCICLMALDKPQAVPVDVHMWHIAQRDYSW-----HPT 274 human
P53397   202 NDKAEAnitsdtTYLQSIcKDAQYEDVREHLMSYNGVGPKVADCVCLMGLHMDGIVPVDVHVSRIAKRDYQIsanknHLK 281 Saccharomyces cerev...
O27397   207 EEMDIR----------RI-DGMDYDDARELLLELSGVGPKVADCILLYGFRKTEAFPVDVWIRRIMNHIHPG-----RNF 270 Methanothermobacter...
AAB68615 217 EEQGGL------AWLQQL-RESSYEEAHKALCILPGVGTKVADCICLMALDKPQAVPVDVHMWHIAQRDYSW-----HPT 284 human
1KO9_A   285 TSQAK-GPSPQTNK----ELGN----FFRSLWGPYAGWAQA----------VLFSADLRQSR-H 328 human
CAA72117 285 TSQAK-GPSPLANK----ELGN----FFRNLWGPYAGWAQA----------VLFSADLRQPS-L 328 house mouse
AAC77525 285 TSQTK-GPSPLANK----ELGN----FFRNLWGPYAGWAQA----------VLFSADLRQQN-L 328 Norway rat
AAB84013 275 TSQAK-GPSPQTTK----ELGN----FFRSLWGPYAGWAQAtpp----slqVLFSADLRQCR-H 324 human
P53397   282 ELRTKyNALPISRKkinlELDHirlmLFKK-WGSYAGWAQG----------VLFSKEIGGTSgS 334 Saccharomyces cerevisiae S288c
O27397   271 NDRSM---VEFARR----------------EYGEMADYVQL----------YLFNHARRSGLld 305 Methanothermobacter thermautotrophi...
AAB68615 285 TSQAK-GPSPQTNK----ELGN----FFRSLWGPYAGWAQAgllgnafdghQLLRPLIFCQD-H 338 human
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