2ISQ,4LHG


Conserved Protein Domain Family
cysK

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TIGR01139: cysK 
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cysteine synthase A
This model distinguishes cysteine synthase A (CysK) from cysteine synthase B (CysM). CysM differs in having a broader specificity that also allows the use of thiosulfate to produce cysteine thiosulfonate. [Amino acid biosynthesis, Serine family]
Statistics
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PSSM-Id: 273465
Aligned: 14 rows
Threshold Bit Score: 472.622
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2ISQ_A         7 VTELIGNTPLVYLNnvA---EGcVGRVAAKLEMMEPCSSVKDRIGFSMISDAEKKGLIKPGEsVL-IEPTSGNTGVGLAF 82  thale cress
CAA58893       9 VTELIGNTPLVYLNnvA---EGcVGRVAAKLEMMEPCSSVKDRIGFSMISDAEKKGLIKPGEsVL-IEPTSGNTGVGLAF 84  thale cress
P37887         8 ITELIGNTPIVKLNrlA---DEnSADVYLKLEYMNPGSSVKDRIGLAMIEAAEKEGKLKAGN-TI-IEPTSGNTGIGLAM 82  Bacillus subtil...
WP_002221210  23 ITELIGNTPLVKLNrlT---EGlKAEVAVKLEFFNPGSSVKDRIAEAMIEGAEKAGKINKNT-VI-VEATSGNTGVGLAM 97  Neisseria menin...
WP_000034403   8 NSLTIGHTPLVRLNr-I---G--NGRILAKVESRNPSFSVKCRIGANMIWDAEKRGVLKPGV-EL-VEPTSGNTGIALAY 79  Escherichia coli
WP_010872080  26 ITELIGRTPLVRLNr-IpllEGcGAKIVVKLEGMNPAASVKDRIGINMINRAEQEGLIEPGK-TLlIEPTSGNTGIALAM 103 Synechocystis s...
WP_010887435   2 IESFIGHTPLVQLRr-Vv--TPdMADVFIKLEGQNPGGSIKDRTALGLVQDAERRGVLKPGG-TI-VEPTSGNTGIGLAQ 76  Deinococcus rad...
WP_002858759   7 VSELIGNTPIIHLK-------KfGINVFAKCEFLNPSHSIKDRAAFEMIKDALDSKKINQDT-TI-VEATSGNTGISLAM 77  Campylobacter j...
WP_010893351  20 ILDTIGHTPVVKLNr-I---APaHVDLYIKVESFNPSGSVKDRLALAIILDAEQQGLLKPGD-TI-VEATSGNTGVALAM 93  Xylella fastidiosa
WP_010895923   8 NSLTIGNTPLVRLNr-Ig-----NGNILVKIESRNPSFSVKCRIGANMIWHAEKNNNINKNV-KL-IEATSGNTGIALAY 79  Buchnera aphidi...
2ISQ_A        83 TAAAKGYKLIITMPASMSTERRIILLAFGVELVLTDPAKGMKGAIAKAEEILAKTPNGY-MLQQFENPANPKIHYETTGP 161 thale cress
CAA58893      85 TAAAKGYKLIITMPASMSTERRIILLAFGVELVLTDPAKGMKGAIAKAEEILAKTPNGY-MLQQFENPANPKIHYETTGP 163 thale cress
P37887        83 VAAAKGLKAILVMPDTMSMERRNLLRAYGAELVLTPGAEGMKGAIKKAEELAEKHG-YF-VPQQFNNPSNPEIHRQTTGK 160 Bacillus subtil...
WP_002221210  98 VCAARGYKLAITMPESMSKERKMLLRAFGAELILTPAAEGMAGAIAKAKSLVDAHPDTYfMPRQFDNEANPEVHRKTTAE 177 Neisseria menin...
WP_000034403  80 VAAARGYKLTLTMPETMSIERRKLLKALGANLVLTEGAKGMKGAIQKAEEIVASNPEKYlLLQQFSNPANPEIHEKTTGP 159 Escherichia coli
WP_010872080 104 VAAAKGYQLILTMPETMSQERRAMLKAYGAKLELTPGSEGMGGCIRRAQELAESLPNAY-MLQQFDNPANPQIHQQTTAL 182 Synechocystis s...
WP_010887435  77 VAAAKGYKLILCMPAQMSEERKRTLRAYGAELILTDPERRMLAAIEEAEKIAAETG--AvMMNQFANPANPATHEASTGP 154 Deinococcus rad...
WP_002858759  78 ICADLGLKFIAVMPESMSLERRKMITLFGARLELTPANLGMKGAVDKANEILLNTPNSf-MVSQFENISNKNAHRKNTAL 156 Campylobacter j...
WP_010893351  94 IAAARGYTFVATMVETFSIERRKLMRAYGAKVILTPAAERGSGMVRKAKELAEQHG--WfLASQFSNPANPAYHRNTTAA 171 Xylella fastidiosa
WP_010895923  80 VAASRNYRLTLTMPETMSIERKKILKSLGAELILTDGRYGMKGAISKANDIISRNPSKYfLLKQFENPANPEIHQITTGP 159 Buchnera aphidi...
2ISQ_A       162 EIWKGTGGK-IDGFVSGI--GTGGTITGAGKYLKEQNA--NVKLYGVEPVESAILSGG------KPGPHKIQGIGAGFIP 230 thale cress
CAA58893     164 EIWKGTGGK-IDGFVSGI--GTGGTITGAGKYLKEQNA--NVKLYGVEPVESAILSGG------KPGPHKIQGIGAGFIP 232 thale cress
P37887       161 EIVEQFGDDqLDAFVAGI--GTGGTITGAGEVLKEAYP--SIKIYAVEPSDSPVLSGG------KPGPHKIQGIGAGFVP 230 Bacillus subtil...
WP_002221210 178 EIWRDTDGK-VDVFVAGV--GTGGTITGVGEVLKKYKP--EVKVVAVEPEASPVLSGG------EKGPHPIQGIGAGFIP 246 Neisseria menin...
WP_000034403 160 EIWEDTDGQ-VDVFIAGV--GTGGTLTGVSRYIKGTKGktDLISVAVEPTDSPVIAQAlageeiKPGPHKIQGIGAGFIP 236 Escherichia coli
WP_010872080 183 EIWQDTDGA-IDFLVAGV--GTGGTITGVASVLKEKKP--SFQAIAVEPQNSPVLSGG------KPGPHKIQGIGAGFIP 251 Synechocystis s...
WP_010887435 155 ELWEQMEGR-VDAFVYGT--GTGGTITGTGRYLKRQDP--NIQVIACEPARSNVLSGG------ERGNHGFQGMGPGFIP 223 Deinococcus rad...
WP_002858759 157 EILRDLDNE-LDIFVAGF--GTGGTISGVGEILKEKLE--KVHIVGVEPLNSPLLSKG------EAGSHKIQGIGANFIP 225 Campylobacter j...
WP_010893351 172 EILRDFAGRrLDHFVSGW--GTGGTLTGVGEVLKIARP--DITITASEPASAALLQGK------EWQPHKIQGWTPDFVP 241 Xylella fastidiosa
WP_010895923 160 EIWNDTNGN-LDILISAVgtGGTITGITRYIKKIKRKK--NLISIAVEPSESPVITQFlagkaiEPGPHKIQGIGPGFIP 236 Buchnera aphidi...
2ISQ_A       231 SVLNVDLIDEVVQVSSDESIDMARQLALKEGLLVGISSGAAAAAAIKLAQRPEnAGKLFVAIFPSFGERYLSTVLF 306 thale cress
CAA58893     233 SVLNVDLIDEVVQVSSDESIDMARQLALKEGLLVGISSGAEAAAAIKLAQRPEnAGKLFVAIFPSFGERYLSTVLF 308 thale cress
P37887       231 DILNTEVYDEIFPVKNEEAFEYARRAAREEGILGGISSGAAIYAALQVAKKLG-KGKKVLAIIPSNGERYLSTPLY 305 Bacillus subtilis s...
WP_002221210 247 TVLNTKIYDSITKVSNEAAFETARAIAEKEGILVGISSGAAVWSALQLAKQPEnEGKLIVVLLPSYGERYLSTPLF 322 Neisseria meningitidis
WP_000034403 237 ANLDLKLVDKVIGITNEEAISTARRLMEEEGILAGISSGAAVAAALKLQEDESfTNKNIVVILPSSGERYLSTALF 312 Escherichia coli
WP_010872080 252 EVLDVNLIDEVIAVTDEEAIAYGRRLAREEGILSGISTGAALAAAIKVAKRPAnKDKLIVMIQPSFGERYLSTPLF 327 Synechocystis sp. P...
WP_010887435 224 DNLDRSLLDDVIQVWEEDAYPLARRLAQEEGIFIGMSSGAMVWTALEVARRLG-PGKRVVTIACDTGARYLTTALF 298 Deinococcus radiodu...
WP_002858759 226 AILNKEVIDEVITVSNEDAINTAKELAKS-GLMVGISSGANVFAASMLAKKF--PDKRILTMLNDTAERYLSTDLF 298 Campylobacter jejuni
WP_010893351 242 EVLNRSVPHHILSVTDDDAITVARRLAAEEGVFSGISGGATVATALQIAQQAQ-PGAVILAMLPDTGERYFSTPLF 316 Xylella fastidiosa
WP_010895923 237 KNLDLTIIDQVITVSSEEAILTAKELMKKEGILAGISSGAALYAAIKIQQQKKfSDKKIVVILPSSGERYLSTELF 312 Buchnera aphidicola
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