1JAG,1P62,1OE0


Conserved Protein Domain Family
dNK

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cd01673: dNK 
Click on image for an interactive view with Cn3D
Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1.113), adenosine (EC 2.7.1.76), and thymidine (EC 2.7.1.21) kinases. They are key enzymes in the salvage of deoxyribonucleosides originating from extra- or intracellular breakdown of DNA.
Statistics
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PSSM-Id: 238836
Aligned: 73 rows
Threshold Bit Score: 134.278
Created: 13-Dec-2003
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Substrate-bin..Substrate
Conserved site includes 9 residues -Click on image for an interactive view with Cn3D
Feature 1:Substrate-binding site [chemical binding site]
Evidence:
  • Structure:Residues in close contact with the substrate in structure 1OE0_D.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1              # ##                                                   #         ##    
1JAG_A      4 RLSIEGNIAVGKSTFVKLLtkt----ypeWHVATEpvatwqniqaagnqkactaqSLGNLLDMMYReparwSYTFQTFSF 79  human
1OE0_D     22 TVLIEGNIGSGKTTYLNHFeky----kndICLLTEpvek------------wrnvNGVNLLELMYKdpkkwAMPFQSYVT 85  fruit fly
AAL55705   72 VICVEGNIASGKTSCLDYFsnt-----pdLEVFKEpvak------------wrnvCGHNPLGLMYQdpnkwGLTLQTYVQ 134 African clawed frog
O00142     52 VICVEGNIASGKTTCLEFFsna-----tdVEVLTEpvsk------------wrnvRGHNPLGLMYHdasrwGLTLQTYVQ 114 human
BAD18437  198 TFCVEGNISVGKTTFLQRIanetielrdlVEVVPEpiskw----------qdvgpDHFNILDAFYAepqryAYTFQNYVF 267 human
AAG51141   48 TFCVEGNISVGKSTFLQRIanetvelqdlVEIVPEpvdkw----------qdvgpDHFNILDAFYSepqryAYTFQNYVF 117 thale cress
AAH76441   21 QICLEGNIASGKTTCLEYFskt-----sdIEVLTEpvsk------------wrnvQGCNPLGLMYQdptrwGLTLQTYVQ 83  zebrafish
AAT71846   23 VYTVFGHVGVGKSSLLRSLant----hhgINVVLEpt-----------------dTWEPFFQLYCKdparwAAAFQMMVI 81  Rock bream iridovirus
AAN04365   28 NILIEGNIACGKSALLNHFknl-----dsFTAIEEplhqw-----------tnfkGYNLLHGMGLDpv-kwFAAFQTYIC 90  HZV-1
P28855     18 VFCVEGNIGCGKSTLVKALmerv--agsgVNVVEEpvdq------------wvnhNGKNYLELSYTdptgyAVPFQNLVF 83  IcHV-1
Feature 1                                        #                                            
1JAG_A     80 LSRLKVQLEpfpekllqarkPVQIFERSVYSDRYIFAKNLFENGsls-------------dieWHIYQDWHSfllwefas 146 human
1OE0_D     86 LTMLQSHTApt-------nkKLKIMERSIFSARYCFVENMRRNGsle-------------qgmYNTLEEWYKfieesi-- 143 fruit fly
AAL55705  135 LTMLDIHTKps-------isPVKMMERSIYSAKYIFVENLYQSGkmp-------------avdYAILTEWFKwivknt-- 192 African clawed frog
O00142    115 LTMLDRHTRpq-------vsSVRLMERSIHSARYIFVENLYRSGkmp-------------evdYVVLSEWFDwilrnm-- 172 human
BAD18437  268 VTRVMQEREssa-----gikPLRLMERSVFSDRMVFVRAVHEANwmn-------------gmeISIYDSWFDpvvssl-p 328 human
AAG51141  118 VTRLMQEKEsas-----gvkPLRLMERSVFSDRMVFVRAVHEAKwmn-------------emeISIYDSWFDpvvssl-p 178 thale cress
AAH76441   84 LTMLDRHVSpm-------saPIRMMERSIYSAKYIFVENLYKSGkmp-------------evdFAVLSEWFEwiikni-- 141 zebrafish
AAT71846   82 HSYRNIYSAnkd------npLPTIIERSPQCCRAFVAWLYATGQldt--------------vsHDTINTHLAavpw---- 137 Rock bream iridovirus
AAN04365   91 TTMFEAHTRpv-------rtPFKIMERSLLSVQNCFIEAVASSImdksdptdadsmallnadvLKSLCEVLIdsv----- 158 HZV-1
P28855     84 DSYVNVQRLq----------NPDIMERSPMSATRVFCAVNGSRGvi----------------pATALPGMAArgeavmrt 137 IcHV-1
Feature 1                            #    #                                                   
1JAG_A    147 ritlhGFIYLQASPqvclkRLYQRAREEEk-gIELAYLEQLHGQHEAwlihkttk------------------------- 200 human
1OE0_D    144 hvqadLIIYLRTSPevayeRIRQRARSEEs-cVPLKYLQELHELHEDwlihq---------------------------- 194 fruit fly
AAL55705  193 dtsvdLIVYLQTSPeicyqRLKKRCREEEs-vIPLEYLCAIHNLYEDwlvkqt--------------------------- 244 African clawed frog
O00142    173 dvsvdLIVYLRTNPetcyqRLKKRCREEEk-vIPLEYLEAIHHLHEEwlikgs--------------------------- 224 human
BAD18437  329 glipdGFIYLRASPdtchkRMMLRKRTEEg-gVSLDYLCDLHEKHESwlfpsqsgnhgvlsvnqlphhidnslhpdirdr 407 human
AAG51141  179 glvpdGFIYLRASPdtchkRMMLRKRAEEg-gVSLKYLQDLHEKHESwllpfesgnhgvlsvsrpslhmdnslhpdikdr 257 thale cress
AAH76441  142 slpvdLIVYLQTSPqtcyeRLKQRCREEEk-vIPLEYLESIHNLYEDwlihqk--------------------------- 193 zebrafish
AAT71846  138 -fsnvTQVYLRCSPtv--aAARALARPNElnsCPPDYMAFLHKQWEArv------------------------------- 183 Rock bream iridovirus
AAN04365  159 --ridLIVYMRTDPsvameRTIRRGRMEEs-hIELPYLEKLHELHEDwlihg---------------------------- 207 HZV-1
P28855    138 iatrpVFVYLELPPeeclrRMRRRDRTGEa-gVGLDYLRLLHERYEAwls------------------------------ 186 IcHV-1
Feature 1                                           
1JAG_A    201 -------lhfealmnIPVLVLDVND-------DFSEEV 224 human
1OE0_D    195 ----------rrpqsCKVLVLDADL-------NLENIG 215 fruit fly
AAL55705  245 ----------sfsvpAPVLVIDGNK-------ELEELT 265 African clawed frog
O00142    225 ----------lfpmaAPVLVIEADHhhmermlELFEQN 252 human
BAD18437  408 vfylegghmhssiqkVPALVLDCEP-------NIDFSK 438 human
AAG51141  258 vfylegnhmhssiqkVPALVLDCEP-------NIDFSR 288 thale cress
AAH76441  194 ----------sfhvpAPVLVIPADH-------DLKKML 214 zebrafish
AAT71846  184 --------------tPDTIIIDAEQ-------DMDTVR 200 Rock bream iridovirus
AAN04365  208 ----------kkpipAPVLVVDANSe------SIKGTI 229 HZV-1
P28855    187 -------------saEDVERVDASRsr----eEIVDRV 207 IcHV-1

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