Conserved Protein Domain Family
pbp2_mrdA
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TIGR03423: pbp2_mrdA 
penicillin-binding protein 2
Members of this protein family are penicillin-binding protein 2 (PBP-2), a protein whose gene (designated pbpA or mrdA) generally is found next to the gene for RodA, a protein required for rod (bacillus) shape in many bacteria. PBP-2 acts as a transpeptidase for cell elongation (hence, rod-shape). [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Links
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Statistics
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PSSM-Id: 274573
Aligned: 72 rows
Threshold Bit Score: 547.122
Created: 9-Oct-2014
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
WP_011219503  20 RRALVSFAGIIALIGVLLTNLYYIQISGHDDYQTRSNDNRIKIVPVAPNRGLIYDRNGV-L-LAENQPVYALEISTD--- 94  Photobacterium ...
WP_012545126   3 iknrifigiiflifiiillRLWQLQILNTEKYKKLAEQNRIRIIKIPAPRGIIYDRNGI-P-LVENIPSFAALISPE--- 77  Thermodesulfovi...
WP_011522269  11 FRLTIVQYVILAIFLILAFGLWRLQVARNDYYSSLAEQNRIKQVPILAPRGKILDREGR-I-IVDNYPSFSVLMLRD--- 85  Candidatus Kori...
WP_011685898  29 gkIAVFQYATVVIFLFLISGFWRLQVQNPQFYGERALQNSIKSVPIPGPRGRLLDRDGR-I-IVDNHSSFQLILARE--- 103 Candidatus Soli...
WP_012674134   4 SRFYFLITLLFLIYFILVGRLFYLQIVKGEYYSEISNRNYIKVFQSNPPRGKIYDRNGV-L-LAYDIPTFDLIAFPY--- 78  Sulfurihydrogen...
WP_002671463  10 SRLRLFSIFVFFILIAYTYKLFSMQIIHGDQFKQKSQNISKRTTVIPAQRGEIFDREANtP-MVLNIDSFAVDIVPG--- 85  Treponema denti...
WP_010881949  14 FRIKVLTWLVVLVMLLYMRQLFVIQIVRGDSFKKKSLNISQRSKVIPAQRGEIFDRHAD-LpMVLNVNSFAVDMIPG--- 89  Treponema pallidum
WP_014517206   1 mrmrlvvgfillffifllSRVYYLSIKSNVYYEELAKQNAIKTEFLPPVRGQITDRNGT-L-LAINDLGFSISIKPYlsi 78  Campylobacter j...
WP_014546565  16 wnVLIFLAGTVILFSVILFKLFSLQYIHYEENFQRSENNRLRRIELIADRGYIYDRNGN-V-LVRNRPSYQIALQAL--- 90  Fibrobacter suc...
WP_011601184   7 FRYKFGILFLIVIMVLYLAILFQMQIGKHLFYDREANVFLSRLEKINASRGEILDSNSN-I-LANNLTMFILKISLQ--- 81  Borrelia afzelii

WP_011219503  95 KVE--N---LN-----DTFARL-KTLM-SVTDEDIERFKKER----RRTR----RF---KSVPILDQLTENQVALFSVNQ 151 Photobacterium ...
WP_012545126  78 YID--K---VD-----VNL--L-AKIL-NISTEDLQKKFKKK----SES-----IY---MPIRIKEDLTFKEIAMLEARR 131 Thermodesulfovi...
WP_011522269  86 QRR--D---LF-----ADVPMI-ADGL-HLDPEELGARIKRI----AASP----GY---QPLFVKDDITPDELAWVEAHK 142 Candidatus Kori...
WP_011685898 104 SAK-------E-----EHLRSI-AQGL-DLDYTDLLLRMRRV----SRQP----KY---VPIVIKDELTPADLAFVNSHQ 158 Candidatus Soli...
WP_012674134  79 IVR--E----N-----YKIEEL-RLLLkNVFGVELDEKTQEI----IRKN----LL---PKITVKKNLTQKDVENFYNYS 135 Sulfurihydrogen...
WP_002671463  86 EVPrqE---FD-----TVINRL-SSIL-KIPVSQIEKKLP-V----SVRR----DF---RSIQIKSNVDYSTVVQVAESI 143 Treponema denti...
WP_010881949  90 EVP--Pe-qFD-----TVLNKL-SHIL-RVPISDIRKKIPD-----AVRR----SF---QTVELRSNVSYEDITAIAQII 147 Treponema pallidum
WP_014517206  79 KKS--NkgiLD-----KELSEL-TNLFpDLNASKLAEIYK-------RND----SYynqDFIKVVDFIPYDEIIPHYSEL 139 Campylobacter j...
WP_014546565  91 EMP--R---KK-----AARDSIfKKLL-NIRDAAGVRLFDSLsldtAFQRirwvRT---RPVRILEDATMEQVAVIEEHS 156 Fibrobacter suc...
WP_011601184  82 QYY--N---MPvatriEMIDFL-SSTL-DI---DKSIILSKL----QEPG----GY---LKDVEIMELTPKMLFKISEKK 140 Borrelia afzelii

WP_011219503 152 HKFPGVEVKAYLKRHY-PYGDALTHVLGYVAKINDRDIQK-LERdekiSNYKATRDIGKLGIERYYEDLLHGTSGYQEVE 229 Photobacterium ...
WP_012545126 132 SEIPGLIIETEIKRYY-PFGPATAHLLGYLGKITEQQIKNnPQY----QNLPSYFLVGQTGLEKIFDDKLIGIPGEKIIE 206 Thermodesulfovi...
WP_011522269 143 AELPELDTITVHRRLY-PKDGFMAHLIGYVGEVSEDMLNS-PKW----ELYNPGDIVGKSGVELQYNDILMGKNGSRQVL 216 Candidatus Kori...
WP_011685898 159 DFFPEMVLIQAQRRLY-PQNGMLAHVIGYTGEISEQELDL-PEY----GKYNAGEMVGKFGIEKQYNDSLMGVDGQRQVV 232 Candidatus Soli...
WP_012674134 136 YMLKGFYLEVVPKRVYtPEANYLPHIIGYVGYPTKEDVEK---N----PDITLNTLVGKSGIEKIYDNLLRGKAGQKAVL 208 Sulfurihydrogen...
WP_002671463 144 DSLPGVSWHSKPVRNY-VDTRSFSHIIGYVGDITTDELTR-FYN----KGYTSNSIIGKAGIEKQYDEILRGTDGVEYRT 217 Treponema denti...
WP_010881949 148 DELPGVSWYSKPVRNY-VETGSFAHVIGYVGEITKEELKR-FYS----KGYRPNSLIGKAGIEKEYDEVLRGKEGHEYRT 221 Treponema pallidum
WP_014517206 140 NLNKTIKIDPVVKRKY-PFGKLASHIIGYVGKANLQDVQE-NEI----A--KLSNYTGKSGIERYYNDILQGEKGTRVYK 211 Campylobacter j...
WP_014546565 157 TELPGVSVIIESRREY-PYGTLASHVLGYTSEISEEQLKL-PEY----ESYSQGDRVGQKGLEQEYDKEFRGKNGLKLVE 230 Fibrobacter suc...
WP_011601184 141 FYYPALLWTYSFKRNY-LVDDSYSHSIGYVGQINQRELRT-FYNv---SGYDNTSTIGKLGIEQVYDNYIRGQEGLIKYK 215 Borrelia afzelii

WP_011219503 230 VNSRGRIIR-TL----KYV-PPIPGQDIKLNIDIELQLFVkeqltvrtqdpdtgEEII---KYKR-GSIVVMDPRDSAVI 299 Photobacterium ...
WP_012545126 207 VDALGRELR-LI----KEA-PPVKGEDIYLTIDALLQEAA--------------YKAF---EGHA-GAFVALKPDTGEIL 262 Thermodesulfovi...
WP_011522269 217 VNSKGKEVG-TL----SDV-AAEPGKQLKLTIDLDVQIAA--------------EQAL---GDSP-GAIIALDPHTGEIL 272 Candidatus Kori...
WP_011685898 233 VDNRGQVRQ-TI----GTK-PAVPGKDLELTIDLDLQTVA--------------ELAM---AGKS-GSIVALDPRSGEVL 288 Candidatus Soli...
WP_012674134 209 VDAFGRQKK-IL----WEK-DPEKGNDIYLSIDIRLQKIV--------------YETFkssGHKS-GAVVIVDPDSYQIL 267 Sulfurihydrogen...
WP_002671463 218 VDAKGRYIEnTT----VVT-PPKMGNNLVLTIDKRIQKLA--------------EDAL---GPRI-GAAVVLKPTTGEVL 274 Treponema denti...
WP_010881949 222 VDARGRYIE-NT----SVTnPPRMGNNLVLTIDRRIQKLA--------------EDAL---GPRI-GAAVVLKPTTGEVL 278 Treponema pallidum
WP_014517206 212 VNALNQEVE-QL----SYT-PAMS-NDIELTIDIELQSYL--------------TSLF---EGNA-GAAIIMNVNDGSIL 266 Campylobacter j...
WP_014546565 231 VNASGREVR-TLpdvgGYI-PPEPGLHMVSTIDLKLQKAA--------------EAAI---PDSAkGALVAIDPRNGEIL 291 Fibrobacter suc...
WP_011601184 216 VDSKERRID-DG----SIIkNMVPGNNVVLNINKDIQDLA--------------KNAL---GKRY-GSIVVLKPSTGAVL 272 Borrelia afzelii

WP_011219503 300 AMVSSPSYDPNLFV--HGISTKNYQALLNNKDRPLVNRVTLGIYPPASTVKPLIAVAALTEGVVTTRTTR-S---DPGWW 373 Photobacterium ...
WP_012545126 263 SLLSSPSFDPNIFV--EGVSGTYWNELINNSQNPLLNRAIQGLYAPGSTFKIITAIAGLEEGVVTPDRILaN---CTGGI 337 Thermodesulfovi...
WP_011522269 273 AMVSRPVFDPNAFS--VRVSRQEWNRLLSDESKPLLNKAIQAQLAPGSTFKVIMSVAGLQEG-IAQNLVV-N---CAGGG 345 Candidatus Kori...
WP_011685898 289 AMVSRPTFDPNKFT--VRIKTKDWREIADNPDHPLMNRAIQAQQAPGSTFKPIVALAGLETGTVDDKWSV-H---CSGGV 362 Candidatus Soli...
WP_012674134 268 AALSYPTYDLQKFY--EGLKQEEWQALTQDKYTPLIDKVFTGRYPPGSIYKPLVSIAALEEGVITPETRI-L---SGSEF 341 Sulfurihydrogen...
WP_002671463 275 AMVSYPFFDQNIFG--KEISSSLAKELFENPDKPLLNRAVDAAYPPASTFKVIMNTAILNEKAFPPETTV-P---CLGEI 348 Treponema denti...
WP_010881949 279 AMVSYPYFDQNIFT--QHNAHELYAQLSHDTRFPLLNRVVNASYPPASTFKIVMSTAILAEKAFPHEKTV-D---CPGEI 352 Treponema pallidum
WP_014517206 267 AAGSFPEYDLNPFV--TGISFKDWDELSNSLDHPFTNKLINGYYPPGSVVKMGVGLSFLNSKNISPSTQY-V---CNGSI 340 Campylobacter j...
WP_014546565 292 AMVSSPRLDPNIFSlkRRERNKGWAHVALDSMRPLTNRAISGVYPPASIFKLVTSGAGLESGIIS-ETKY-YpkaCTGGY 369 Fibrobacter suc...
WP_011601184 273 ALHNYPYYSM----------RDVYNKY-NKEDYSFLNKAIQSVYPPASIFKLVVAAAILEERVIDKDRKI-Y---CPGYF 337 Borrelia afzelii

WP_011219503 374 KIPNtnsRPFRDW-RRWGHGKVNIHKAIEESVDTFFYQIAYD-LGIDRLSSWMTKFGYGEY-TGIDIHEESKANMPTREW 450 Photobacterium ...
WP_012545126 338 SFGT---WTFGCW-KKEGHGPVNLIRALIESCDVYFYELGRI-LGIGKIYKYATLLGLGNS-TGFS-SEEKSGLVPDEEW 410 Thermodesulfovi...
WP_011522269 346 DFYG---RFFKCD-QH--HGSVNISKAIYDSCDTYYYTLGEK-LGIGKIAFYASEFGLGKK-TGVDLPQEVSGIMPSEEW 417 Candidatus Kori...
WP_011685898 363 ALYG---KYQRCW-QKGGHGTLSMHSGIVHSCDVYFYTLGSK-IGINNLAFYGDLVGFGQA-TGIDLPHENIGLMPSEKW 436 Candidatus Soli...
WP_012674134 342 SIGK---YRYRNW-NKAGCGYINVAQALEMSCDTFYYQVGLK-LGVDNIFKYTKLFGIGEK-LNPDI-EKKVAIVPNREW 414 Sulfurihydrogen...
WP_002671463 349 EYGN---RVFRCHiRKPGHGKLALNEALAKSCDIYYWTVCRDyLGVEKIVDYAKRFGLGQS-TEIDLPSQSDGFVPSPRW 424 Treponema denti...
WP_010881949 353 EYGN---RLFRCHiRKPGHGKVDLRRALEQSCDIYYWTVCRDyLGIDRMISYINDFGFGKS-ARIDLPSQTEGMVPTPKW 428 Treponema pallidum
WP_014517206 341 ELGG---RFFRCW-NRSGHGPVDLKHAIKYSCDVYFYNGSLQ-VGIDQISETLSRIGFGTK-TGVDLPSEFVGTLPSKEW 414 Campylobacter j...
WP_014546565 370 QYGA---RYQRCW---GVHGNLNVVHALRLSCDVYFYQAGLE-IDMARINEFARRFGYGEKlLGIDIPGEKAGWLPDSAS 442 Fibrobacter suc...
WP_011601184 338 KVGN---RIFHCW-KPGGHGYVNLEEAIAHSSNVYFYTLGLKyLGVDRIRKYAKEFGFGEK-TGIDLPNEVSGLLPSPEW 412 Borrelia afzelii

WP_011219503 451 ---KQARFRQPWYQGDTIPVGIGQGYWTATPLQIAKATTVLVNQGVVRPPHLLKSII-Nd-NTETLAAFD-EYAPITG-V 523 Photobacterium ...
WP_012545126 411 ---KKKIKKTSWFLGDTFNTAIGQGFLKVTPLQMANVMATMVNGGTKITPYIIRGTE--------------PYKENLN-L 472 Thermodesulfovi...
WP_011522269 418 ---KAKNYKQKWFAGETISVSIGQGAVAATPIQLARALGGIAMGGELHTPHVAFPND-Lp-QQYQPVAEKsGEVEHIR-I 491 Candidatus Kori...
WP_011685898 437 ---KLRNYRTKWYAGETPSVAIGQGAVIVTPLQLARAIGGMAIGGRWYQPHMVR------------RPVEeVKETEWK-L 500 Candidatus Soli...
WP_012674134 415 ---KRKVLKQPWFHGDTVNLSIGQGYLSITPFDATKIVVPIANGGKVLKPQILKGYY-Dn-KRQMFVHIKpEVIRKIK-I 488 Sulfurihydrogen...
WP_002671463 425 ---KERRFHEKWLNGDTMNMSIGQGFTLASPLQVANMACMVINNGVIYKPHLLKEIR-DpsSGEVIKTVQpEILHKEN-I 499 Treponema denti...
WP_010881949 429 ---KERRFHEKWLDGDTMNLAIGQGYMLVSPLQVANMVAMTVNNGVIYRPHLLKEIR-DsrTNEVLFRHKpEVLKTAK-I 503 Treponema pallidum
WP_014517206 415 ---KMQRYRQSWFQGDTLNTAIGQGNFLATPMQIARYTAQIAKGGEVI-PHFLKSIE-Nn-NTTIENQMDeNKKEIFT-L 487 Campylobacter j...
WP_014546565 443 fnqRNKRLGWRWARGLILNLSIGQGQM-VTPLQQAVFIGSLATNKGVYRPHFMKELQ-Ds-QGNVVRRYEpEIIRPGT-M 518 Fibrobacter suc...
WP_011601184 413 ---KEKTFNQSWVGGDTVNFSIGQGFLNATPMQIVNMVAMIANEGVVYKPRIVNKILkGg-TNEVILENKpEILRKTNlI 488 Borrelia afzelii

WP_011219503 524 -TDQNWEIAKDGMYRVLYGVRGTARRAFYGAQYKAGGKSGSAQVFGLAKDQK--YNAEELEEHLRDHALFTAFAPYD--- 597 Photobacterium ...
WP_012545126 473 -NPKNLEIIKDALSGVVNEPNGTASSARSY-MIKFGGKTGTVQVVSKKLKEK--VSYKNIE----HHAWFIGFAPVE--- 541 Thermodesulfovi...
WP_011522269 492 -DPENWQVITDAMADVTKI--GTASAAHLN-GIDFAGKTGTAQTISMEARSK--LGAE-GKKKFSDNAWFVGMAPRR--- 561 Candidatus Kori...
WP_011685898 501 -DPEHVKIVKDGMYGVVNE-GGTGIRAALP-HLEICGKTGSAQLASN----E--FVKGSSSKDLKDNAWFVGFAPRE--- 568 Candidatus Soli...
WP_012674134 489 -KIWNLEAVRYGMYLVVYGPQGTA-KALKSVPVKNAGKTGTAQVYTYLTRQK-----KHGKWELRDHAWFISFAPYD--- 558 Sulfurihydrogen...
WP_002671463 500 -GKEVFEQVRQAMNLVTI--QGEARYPMKNPMFRFAGKTGTAEV----------------GLHDRWHSWMVAYGPYD--- 557 Treponema denti...
WP_010881949 504 -PAEIFEHVRADMHSVVT--RGSSQYAMKNKTVSLAGKTGTAEV----------------GFHNRWHSWMAAYGPYH--- 561 Treponema pallidum
WP_014517206 488 fEKSQLPYIRDAMYAVANEQGGTSYRYLHNLDVKVAAKTGTAQVVGFSQTDKnrVDEKQFEYYTRSHAWLTSYAPYS--- 564 Campylobacter j...
WP_014546565 519 -KPETHRVLMNAMDSVVNHPGGTGKKGAVP-GIRVGGKTGSGEWKKGQKT----------------HAWFAAVAPLD--- 577 Fibrobacter suc...
WP_011601184 489 -SKNTFKLLKKYMRSVVT--YGTARYAVLTKAVKV--------------GGK--TGTGQTGIDGFENSSFIGLAPYNgsa 549 Borrelia afzelii

WP_011219503 598 KP---E---IVVAMVLENAG----GGSSNgGPLARKIFD-HVLLK 631 Photobacterium profundum
WP_012545126 542 KP---E---IAFSVIVEHGG----SGGAVaAPVAKNILE-GYILK 575 Thermodesulfovibrio yellowstonii
WP_011522269 562 DP---Q---IVVAVLYQ-GG----GWGWHsGLLAAQVIK-AYvek 594 Candidatus Koribacter versatilis
WP_011685898 569 NP---E---IVVVALWEHGE----HG-QFaAALVRDVMK-AYFDK 601 Candidatus Solibacter usitatus
WP_012674134 559 NP---K---LAGVVFVEHGE----SGGGVaAPLMANILK-RAYse 592 Sulfurihydrogenibium azorense
WP_002671463 558 AP---PkdiIVVSVIVEAVN----EWEWWaPYAANIILH-GTLAN 594 Treponema denticola
WP_010881949 562 RPpdeA---VVVVVLVEARN----EWEWWaPFATNIIFQ-GIFAN 598 Treponema pallidum
WP_014517206 565 KP---K---YVVTVLLEHGGrnitSGATVa-KIYQKMIDlGYFk- 601 Campylobacter jejuni
WP_014546565 578 DP---Q---IAVAVIMEAAG----GGGSVaAPIAHKVLM-AFFGK 611 Fibrobacter succinogenes
WP_011601184 550 DN---Q---IIVFSLVEAKS----NVDWWpAKSTDLIMQ-GIFAN 583 Borrelia afzelii
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