cd00992: PDZ_signaling (this model, PSSM-Id:238492 is obsolete)
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. In this subfamily of PDZ domains an N-terminal beta-strand forms the peptide-binding groove base, a circular permutation with respect to PDZ domains found in proteases.
Feature 1:protein binding site [polypeptide binding site]
Evidence:
Comment:contains the GLGF loop, a carboxylate-binding motif
Comment:PDZ binds to either the terminal COOH group of a peptide ligand (1KWA) or an internal peptide sequence that mimics the PDZ binding motif (1QAV)
Structure:1KWA; CasLIN-2 PDZ and C-terminal polypeptide ligand complex