Conserved Protein Domain Family
Rad51C
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cd19492: Rad51C 
RAD51C recombinase
RAD51C recombinase, a RAD51 paralog, plays an important role in DNA repair by homologous recombination (HR). HR is an important error-free repair mechanism for chromosomal double-strand break (DSB) which otherwise leads to cell cycle arrest and death. RAD51C, together with the other RAD51 paralogs, RAD51B, RAD51D, XRCC3, and XRCC2, helps recruit RAD51 to the break site. Additionally, RAD51C acts as a mediator in the early steps of DNA damage signaling.
Links
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Statistics
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PSSM-Id: 410900
Aligned: 25 rows
Threshold Bit Score: 191.669
Created: 16-May-2012
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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ATP binding
Feature 1:ATP binding site [chemical binding site]
Evidence:
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                   ######                           #                                    
XP_788113     141 CKITEICGAPGVGKTQTCIQLCVDvqipaslggveGEAVYIDTEGSFipqrawgiaqaatehcht-----------mgdq 209 
XP_002177796  105 GELTEIAGPPGVGKTQWGMQLAVDarlpntfggvaGETVYVDTEGSFsperchdmatslvqhieagrrr--rqekgqklq 182  Phaeodactylum...
XP_002130341   37 GSITEIAGESSTGKTQLCFQLATNahihtkyggvgGETVYIDTEMTFkterigqiaqamvhhf--------------ert 102  Ciona intesti...
XP_001230756   37 GMITELCGPPGSGKTQLCLQLAVNvqipqqlgglqGRAVYLDTNYGFfpqrvqemakachnhcanial-----lhklnpe 111  Anopheles gam...
XP_001944618   93 GRITELSGAPGSGKSQLSMQLCVSvqipvcfeglqGEAIYVDTNSNFselrltemidaflghvskvlsgp-ndfkgaans 171  pea aphid
XP_002058339   35 GKVYELVGKPGTGKTQLCMKLCLNvqipryacglaSKALYFDTRKDFnparlkeladdlaarl---------------rc 99   Drosophila vi...
NP_001152813   89 RVITELSGVPFSGKTQICMQLCISvqlnkcyggldGRAIYIDTRSGTcasrfkdivrglnk------------------s 150  jewel wasp
CCA23112      107 GEVMEICGGPGLGKTQFAIHVCLAssv-----pfkGRSIYIDSEGSFviervaqmaahfvedy---------------kl 166  Albugo laibac...
GAA56912     1428 GRLTELCGEPGVGKTQFCIQTCLTvqlprwfggleGEAVFIDSEGNFvprrakqmaeslvthcrrhveldvddepltkef 1507 Clonorchis si...
NP_733200      64 GHLVELIGNSGTGKTQMCLQLCLNvqipkaaggleGSALFIDTRQDFhpdrlmglalklerq----------------ya 127  fruit fly

Feature 1                                                             #                           
XP_788113     210 aelkdfttekilsGIHYFRCHnhVELLALVNLLPEFlsk----npKVKLIIVDSIAFHFRhdfddm--slrtrlLNGLAQ 283 
XP_002177796  183 pmpawfapdtilqGIHVYRVHdeAAQTSVLYSLPKFlqdrqeagtPVRLVVVDSMAFHHRaappnsdfvgrtrsLTSQAA 262  Phaeodactylum...
XP_002130341  103 khatdmsadtvlsGIYLFRCIkmVQLLAVSYQLFEFvks----hpKVKLVIVDSIAQXXRaeedmk---irnklLNNLAA 175  Ciona intesti...
XP_001230756  112 etlagfseataldNILYSHVTncTQILEAIAVLQNRlyd----geKIKLIVLDSLSFLIRntntrs--mkrvkrVHEILT 185  Anopheles gam...
XP_001944618  172 ellkslttagmlsKIHRVQMNdlNQLHALYTTLERHp--------NVKLIVVDSFVMPLYqvensl---rkntlVHSALD 240  pea aphid
XP_002058339  100 tsisaptatqmlqNVYYVDCRntAQLVAGLLNCHKYlek----epNIKLIIVDSISFAIRmvnnvs---drtelLMEVHD 172  Drosophila vi...
NP_001152813  151 hkdlnlnadevlkCIEILSPNsvEEFVQIIDSLKFKmksn-kdekKVRLIIVDSLSMPILcciddp--tkrpyyYSHILH 227  jewel wasp
CCA23112      167 pgeeistrddilrSIHYYRVHdyVEQMQVIQSLFNVlrq----dpKICTLVIDSLAFHLRhsfedt--gararaTESAAI 240  Albugo laibac...
GAA56912     1508 rnhycpnvdsllsGIHYIRVTdhLQLLATCKRLQQFceq----hpKVRLVVVDSIALPFRydfddi--pqrnrlLACVAQ 1581 Clonorchis si...
NP_733200     128 hrvpefkahkmlqKIHYVRCPklDQLMATVLSCHRHlvd----hpDIKLIVIDSLAFTLRmledga---hryemLLELHE 200  fruit fly

Feature 1                          #                                              #               
XP_788113     284 NFIRIATqyNLAVVLTNQMttkigeg---------------tshlipaLGESWGHACTIRVILYWkq----------aqR 338 
XP_002177796  263 FLTNLAAqsGIAVVAINQMttkmttse--------------askqvpaLGESWAHAVTTRILLSRpisd------tngvR 322  Phaeodactylum...
XP_002130341  176 NLRKIASllNVAVVLVNQVttrfdeyg--------------nscmvpaLGESWSNIPHTKLFLYKlq----------glR 231  Ciona intesti...
XP_001230756  186 LLHKLAHrfGCVVIVTNDVttrisdvdgggg------erpdvpqivpaLGGSLTHKVNQRIFLGRdeshfdaqsqappsY 259  Anopheles gam...
XP_001944618  241 LLQTIAVehDLAVLLTNDLttavtes---------------gtevfpaLGESFGHRVQYRLLLSKipnr-------pneY 298  pea aphid
XP_002058339  173 GMRKLQLmhDLAFVITNNQgyrrrms---------------qfqleavLGRKHSQLINKRIWLTEnecfvgk-raktkrL 236  Drosophila vi...
NP_001152813  228 KLHKLALinELAVVITNELvmqvdkdg--------------ksyfaaaGGQYVADYASVKLEMTRltd---------hkF 284  jewel wasp
CCA23112      241 KLHELARefRIVVFIVNYMttkyhgdhrlpsa----pfdtmngleipaLGDSWSHAIATRLYLNEdl----------stR 306  Albugo laibac...
GAA56912     1582 QLLSVATnyKAVVILTNQIttrietrvksdenppgsdytsstgrlvpaLGESWGHICAVRIFLTRssd---------icR 1652 Clonorchis si...
NP_733200     201 SMRRLQRqhELTWVFTNVLthryvkq---------------kfqvepaLGDLHSHLINERIWFSGs-------------S 252  fruit fly

Feature 1                 
XP_788113     339 YANLYKSP 346 
XP_002177796  323 TCTLVKSP 330  Phaeodactylum tricornutum CCAP 1055/1
XP_002130341  232 FALLTKSP 239  Ciona intestinalis
XP_001230756  260 VASIEKGH 267  Anopheles gambiae str. PEST
XP_001944618  299 TALLKKSV 306  pea aphid
XP_002058339  237 ICKLLKYT 244  Drosophila virilis
NP_001152813  285 ATCLLKSP 292  jewel wasp
CCA23112      307 SVHLIKSS 314  Albugo laibachii Nc14
GAA56912     1653 QCKLLKHP 1660 Clonorchis sinensis
NP_733200     253 ELHLGKSW 260  fruit fly

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