Conserved Protein Domain Family
DUF4457

?
pfam14652: DUF4457 (this model, PSSM-Id:405355 is obsolete and has been replaced by 434098)
Domain of unknown function (DUF4457)
This family of proteins is found in eukaryotes. It is found repeated several times in the vertebrate KIAA0556 proteins.
Statistics
?
PSSM-Id: 405355
Aligned: 21 rows
Threshold Bit Score: 407.09
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
?
Aligned Rows:
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
XP_003291217 1304 FSFLSTWGDRFYMGLTSIMI-FDNEYKQIPLTVLNITAHPKDINDVPGHS--GDYRTLDKLIDGHNITTNDKHMWLIPFY 1380 Dictyostelium...
7_pfamImport    1 LRLISNWG-GSHIGLVGLQM-LGEESELIPIELHRIKLMTNELAGG------GDASDINRIINGTNITMDSNKMWQIPFS 72  
XP_004994397 1496 LNFVETWGDPYYLGLTGLQL-IDEHGGVIAVSMRQVEAVPRDLNDLPNVY--DDDRTLDKLFDGTNITTDDEHMWLIPFT 1572 Salpingoeca r...
A0DSF5       1016 IKLLRPWADQPYIGLTGVEI-YGKEGK---IQVKNIKS---------DYQsdGDKGNIVSLINGINVTTNDMNMYILPFQ 1082 Paramecium te...
2_pfamImport    1 LQLHNTWGDRNYIGLTQVEVlVGSRGTSIPLDAANIDATPRDLASL-GYV--GDPRTLDKLIDGEATTCDDTHMWLVPME 77  
EFC44811      926 IILESSWGDLFYIGLTGIEV-LGKDEKLIKVTTEQLSAKPRDMNEVAGHS--GDYRTLDKLVDGLNVTTDDRHMWMVPVT 1002 Naegleria gru...
EEY56508      513 LILEANWGDPYEIGLAGLEF-LDSSYVPLSISLDSVTISAPIAE--------DRMKKLLTTHGARHLAVDPEEMWTAPLR 583  Phytophthora ...
EFA83430     1789 IQFKSTWGDRYYLGLTSIEV-YDENYQLIKLQLSNLIANPKDINDLPGHS--GDYRTLDKLIDGKNVTTDDQHMWMIPFR 1865 Heterostelium...
Q553C0       2012 FLFLSTWGDRFYMGLTSIMV-FDNEYKQIPIQASNITAQPKDINDVPGHS--GDYRTLDKLIDGHNVTTNDKHMWLIPFS 2088 Dictyostelium...
XP_001014941 1667 IFIHKSWEDKFYVGLTGIEV-YDEYGQKIPLKESQLKARPKDLNEISGYH--GDQRTLDKLIDGVNLTTNEKHMWLVQLL 1743 Tetrahymena t...
XP_003291217 1381 -----PSKEH--TLTIDLGVPMSISCIRVWNYNK--SVE-----DSSRGAKKVNIYLD-GNSlcgg-------------- 1431 Dictyostelium...
7_pfamImport   73 --------GNpcVISVNFVQAVQITGFRVWNYNA--SFE-----DTYSGVKEVVIELD-GQVftt--------------- 121 
XP_004994397 1573 -----PTGDH--LITFFFDTPTTVSALRFYNYNK--SAD-----DIYRGAKRVFVSVD-DTDvsp--------------- 1622 Salpingoeca r...
A0DSF5       1083 -------PGRciTLTFTFDIPQLITSIRIWNYNK--SYD-----DTFRGAKFISLQNDqGIIsn---------------- 1132 Paramecium te...
2_pfamImport   78 -------AASvpEVRIEFKKGQYFFGLRIWNYNK--SSE-----DSFRGVKQLTVALD-GVVispk-------------- 128 
EFC44811     1003 ------LFKErpYIEIDLRKETEISGLRFFNYNK--NLE-----DTFRGVKKISILLDdKPLldne-------------- 1055 Naegleria gru...
EEY56508      584 evlalPLERR--AITITFSEKVSLRALKIWNYNT--TLE-----GSFKGTKQVSVRID-GVHht---------------- 637  Phytophthora ...
EFA83430     1866 qkhqhDQTDY--HLTLDLGVETTLSCLRVWNYNK--NAD-----DASRGAKEVVISLD-GKClt---------------- 1919 Heterostelium...
Q553C0       2089 -----PSKEH--VLTIDLGNVFSISCIRIWNYNK--SLD-----DASRGAKKVNIFLD-GQSlspppaaaassssssssp 2153 Dictyostelium...
XP_001014941 1744 -------EQPqnYLQIDFMEEKIISGIKIWNYNKqqSYNdcksvDQYRGAKIISIVADeNIQitp--------------- 1801 Tetrahymena t...
XP_003291217 1432 ---------nnncFIFRKAPGNSI-FDFGQTISLynWNKQn----------VSPPSTsssveqpltss------------ 1479 Dictyostelium...
7_pfamImport  122 -----------nsFVLRRAPGHVH-YDFAQDVHFe---------------sKKAALVgspsfkpknna------------ 162 
XP_004994397 1623 ----------sggYLICIAPGSAA-FDFAHTVSLhpRHRR-----------YPPASIhhkqltp---------------- 1664 Salpingoeca r...
A0DSF5       1133 ------------cIALKRAPGCDT-YDYAQTITIpskeyvfeet------------------------------------ 1163 Paramecium te...
2_pfamImport  129 ----------etgFLLRKAPGAAN-FDFGQLLRF--------------------PDIvekrvtypfst------------ 165 
EFC44811     1056 ----------escFILKKAPGNTN-FDFGHTILFseTGTTsnr------nsLENMTSkskensargsslrnssllnegiq 1118 Naegleria gru...
EEY56508      638 ------------rVSLRKAPGNLMdFDFGQFLYL-----------------QAECTRpssprlirkks------------ 676  Phytophthora ...
EFA83430     1920 -----------sgYIFRKAPGESN-FDYGQTLSFi---------------hHDKHSQesisesydkmm------------ 1960 Heterostelium...
Q553C0       2154 lnniqnnnqnnygFIFRKAPGNST-FDFGQTISFfnWDKLnnnnnnninnnNNPPSScss-------------------- 2212 Dictyostelium...
XP_001014941 1802 ----------qqgILLRKAPGRDL-FDYGQMIAL------------------PFESGwtqeviqslql------------ 1840 Tetrahymena t...
XP_003291217 1480 -------ktnissivpqPRSLDNYPSGFTLKVLIISNHGDKNLVGLNAIEFYDQNDNLI------------KSSKSNIL- 1539 Dictyostelium...
7_pfamImport  163 -------itahnhphsdQYETPNAPTGFVYKFELLDTWGDLYYIGLNGLELYDEHGQLLklten---eiaaFPSSVNILd 232 
XP_004994397 1665 -----------rwnatnSYIVPAPPRVLRLSLRLIDTWGDLHYIGLNGLQLLDAFGAEIpltpq---nihaVPESVNVLp 1730 Salpingoeca r...
A0DSF5       1164 --------tqvqkqlrcEYEINNLMVGHELKIQLITTFGDIHYIGLNGLEILDYKGrqvqg------nigaEPSSVRILq 1229 Paramecium te...
2_pfamImport  166 -------rayktpiirqDYEAQLYPQGFLLKIVCWQTWGDPYYLGLNGLELYDFAGARIdhkpa---ivsaVPYSVSELd 235 
EFC44811     1119 qailkaqsmqnlqpprqDYQTALLPCAYTFKFHLISSLGDPYYVGLNGIELFDARHERIpltva---niqaSPYSVS--- 1192 Naegleria gru...
EEY56508      677 -------amkpiaevfqQYQTPLFPTGYIIKFVFSSTWGDTFYLGLNGVELFDRDNQLIplyse---ivdaQPRDINVLk 746  Phytophthora ...
EFA83430     1961 -------ifskqsyipqDYKTLFIPSGFVFKFVLLSSWGDKSYLGLNGMQLFDWNEDLIdvsks---rtvlLPPALNN-- 2028 Heterostelium...
Q553C0       2213 --------------gtdQNKISQYSSGFVLKLVIISNYGDRNFVGLHAIEIYDQNDTII------------KPNKSSVL- 2265 Dictyostelium...
XP_001014941 1841 -------ptqvnsqiiqEYDTLYLPRGFCFRFNIHSTWGDAHYCGLNGIEFYDSFGNPIiqkrlaefklgaEPASVNILp 1913 Tetrahymena t...
XP_003291217 1540 -----TNDTKYSFRVVE--NgLTHLENQGI--------------LIPFYSVSfgslhqhlphntqlcqqfpq----ypsp 1594 Dictyostelium...
7_pfamImport  233 q---sLDDVRTPDKLINgiN-DTLDGRNMW--------------LSPVLPGQ---------------------------- 266 
XP_004994397 1731 g---vSGDARTPDKLVDghY-NTNNDYHMW--------------LTPHTPGK---------------------------- 1764 Salpingoeca r...
A0DSF5       1230 s---mRGDKRVVENLLDgiN-ETQNDTHMW--------------LAPFTNRCfdhs------------------------ 1267 Paramecium te...
2_pfamImport  236 htngrQQDTRTPDNLMSglDkNTWEAHDAW--------------LAPLASSLgn-------------------------- 275 
EFC44811     1193 -----KDDVRTPDKLLDgvN-NTWNDSHMW--------------LTLIEPGQ---------------------------- 1224 Naegleria gru...
EEY56508      747 ep-gaTHDVRTLDKLYDgvN-NTYDDRHMW--------------LAPHTPSH---------------------------- 782  Phytophthora ...
EFA83430     2029 -----ASNDQTLSRLFDgiN-SGFDEKHAWcthalypydrsstgLIPI-------------------------------- 2070 Heterostelium...
Q553C0       2266 -----SNDVKNSYKLIG--NnLSFQESEGF--------------LIPYFSVSfgnsnnnngmsplyhqqqqqqyqlggns 2324 Dictyostelium...
XP_001014941 1914 g---cQGDIRTIDKLVNcqN-DTFDDRNMW--------------LAPFINSRsdknvi---------------------- 1953 Tetrahymena t...
XP_003291217 1595 nknsnnraeppsfskeNNVIYFYFNSPIIISKIKIWNYYKVPAQAIKDFAVYLDDLLISQGVLQKP 1660 Dictyostelium purpureum
7_pfamImport  267 ----------------VNLIYVVFDFPVTISMIKIWNYAKTTSRGVKTVAILVDDLLIYNGFLPP- 315 
XP_004994397 1765 ----------------AAVVEVLLPQPIMLGALKLWNYSKTPKRGVRHLQLWADGRIMFEGFVHPG 1814 Salpingoeca rosetta
A0DSF5       1268 ------------qdpqINSLYFGSEQPFALGCIVFWNYTKTPARGVHEIAISLDDYIIYRGYLRQA 1321 Paramecium tetraurelia
2_pfamImport  276 --------------qqGNIVYIGFDTPVVLSMIKFWNYSKTPERGVKDLDIYLDDMHLFSGTLRKA 327 
EFC44811     1225 ----------------DNYLYITFEEPIAVSFIKIWNYSKTPSRGVEELIVYADDVIIYKGFLRMA 1274 Naegleria gruberi
EEY56508      783 ----------------PNKLVLFFNEPMTISKIRLWNYSKTPTRGVREFEVFLDDVLIYHGILKQA 832  Phytophthora infestans T30-4
EFA83430     2071 ------------------SICLYFDYPISLSMVKIWNYSRVPTRGVEEFAMYIDDLLLFKGKLSPS 2118 Heterostelium album PN500
Q553C0       2325 vsynsrgleipsfskeSNVIYFYFDSPITVGKIKIWNYFKNISQAIKEYSIYLDDLLINQGTLQKP 2390 Dictyostelium discoideum AX4
XP_001014941 1954 -----------cphlkMNTIYLFFEKPVIISAINFWNYSKTPSRGVREIEIFLDDKLLFRGYLKKA 2008 Tetrahymena thermophila SB210
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap