2HHL


Conserved Protein Domain Family
HIF-SF_euk

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TIGR02251: HIF-SF_euk 
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Dullard-like phosphatase domain
This model represents the putative phosphatase domain of a family of eukaryotic proteins including "Dullard", and the NLI interacting factor (NIF)-like phosphatases. This domain is a member of the haloacid dehalogenase (HAD) superfamily by virtue of a conserved set of three catalytic motifs and a conserved fold as predicted by PSIPRED. The third motif in this family is distinctive (hhhhDNxPxxa) and aparrently lacking the last aspartate. This domain is classified as a "Class III" HAD, since there is no large "cap" domain found between motifs 1 and 2 or motifs 2 and 3. This domain is related to domains found in FCP1-like phosphatases (TIGR02250), and together both are detected by the pfam03031.
Statistics
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PSSM-Id: 274055
Aligned: 12 rows
Threshold Bit Score: 203.294
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2HHL_A              28 KKCVVIDLDETLVHS---------SFKPIS-----NADFIVPVEIDg----------tIHQVYVLKRPHVDEFLQRMGQL 83  human
AAH18265            61 RKILVLDLDETLIHShh------dGVLRPTvrpgtPPDFILKVVIDk----------hPVRFFVHKRPHVDFFLEVVSQW 124 house mouse
AAL89965            95 RKTLVLDLDETLVHScyldpdthdNVGCSQlpehaQPDYVLNISIDgm---------ePIVFRVFKRPHVDEFLDFVSKW 165 fruit fly
CAD25846            48 KPTLVLDLDNTLVYS---------TFRMPK-----LYDFCVEIPRSr-----------NILIYVKARPYAAEFISAAEAL 102 Encephali...
CAD51523            57 TMTLVLDLDETLIYC---------TKKRKY-----HYQKEVDVLINg----------kYLPLYVCKRPYIDLFFSSLYPF 112 Plasmodiu...
AAH52660           286 EFSLVLDLDETLVHC---------SLNELE-----DAALTFPVLFQd----------vIYQVYVRLRPFFREFLERMSQM 341 house mouse
BAB63547           363 KVTLVLDLDETLVHS---------TTEQCD-----DYDFTFPVFFDm----------kEHMVYVRKRPHLHMFLQKMAEM 418 Oryza sat...
CAD71008           339 QKTLILDLDETLIHSms------kGGRMSSg---hMVEVRLNTTYVgvggqqtigpqhPILYYVHKRPHCDEFLRRVSKW 409 Neurospor...
XP_004471231       146 KKCVVIDLDETLVHS---------SFKPIS-----NADFIVPVEIDg----------tIHQVYVLKRPHVDEFLQRMGQL 201 nine-band...
AAG10616            75 KRTIILDLDETLVHA---------TTHLPGv----KHDFMVMVKMEr----------eIMPIFVVKRPGVTEFLERLGEN 131 thale cress
NP_191155           97 RLKVVLDLDETLVCAye-----tsSLPAALrnqaiEAGLKWFELEClstdkeydgkpkINYVTVFERPGLHEFLEQLSEF 171 thale cress
FlyBase:CG12078-PA  70 RKTLVLDMDNTMITSwf-----ikRGKKPKnipriAHDFKFYLPAY------------GATIYVYKRPYLDHFLDRVSKW 132 fruit fly
2HHL_A              84 FECVLFTASLAKYADPVADLLDRWg-vFRARLFRESCVFHRGN-YVKDLSR-LGRELSKVIIVDNSPASYIFHPENAVPV 160 human
AAH18265           125 YELVVFTASMEIYGSAVADKLDNSrsiLKRRYYRQHCTLELGS-YIKDLSV-VHSDLSSIVILDNSPGAYRSHPDNAIPI 202 house mouse
AAL89965           166 YDLVIYTASLEVYAAQVVDHLDAGrglITRRFYRQHCRASSPM-VSKDLTL-VTPDMSGVLIIDNSPYAYRDFPDNAIPI 243 fruit fly
CAD25846           103 YEVVIFTSAKREYAKKVVDRID-TnknISRILYRESCTFTNGR-YVKDLRK-VGRSLDRVILIDDNPYSYELQPRNGIHI 179 Encephali...
CAD51523           113 YEIIIFTTAIKSYADTVLNIID-VdhyIDKKFYREDCYEMNEKlYIKNLTN-IKKELSKIILIDDSNISGFQYPDNFFPI 190 Plasmodiu...
AAH52660           342 YEIILFTASKKVYADKLLNILDPKkqlVRHRLFREHCVCVQGN-YIKDLNI-LGRDLSKTIIIDNSPQAFAYQLSNGIPI 419 house mouse
BAB63547           419 FEVVIFTASQSVYADQLLDILDPEkklFSRRYFRESCVFTNTS-YTKDLTV-VGVDLAKVVIIDNTPQVFQLQVNNGIPI 496 Oryza sat...
CAD71008           410 YNLVVFTASVQEYADPVIDWLESDrkyFSARYYRQHCTFRHGA-FIKDLSS-VEPDLSKVMILDNSPLSYMFHQDNAIPI 487 Neurospor...
XP_004471231       202 FECVLFTASLAKYADPVADLLDRWg-vFRARLFRESCVFHRGN-YVKDLSR-LGRELSKVIIVDNSPASYIFHPENAVPV 278 nine-band...
AAG10616           132 YKVVVFTAGLEEYASQVLDKLD-KngvISQRLYRDSCTEVNGK-YVKDLSLvVGKDLRSALIVDDNPSSYSLQPENGVPI 209 thale cress
NP_191155          172 ADLILFTAGLEGYARPLVDRIDTRk-vLTNRLYRPSTVSTQYRdHVKDLLS-TSKNMCRTVIVDNNPFSFLLQPSNGIPC 249 thale cress
FlyBase:CG12078-PA 133 YDLTVFTSGAEIYASPILDFLDRGrgiLNSRLYRQHCIEQFGK-WSKSVLL-ACPDLSNVVLLDNSSTECSFNAENAILI 210 fruit fly
2HHL_A             161 QSWFD-DMTDTELLDLIPFFEG-LSREDD 187 human
AAH18265           203 KSWFS-DPSDTALLNLLPMLDA-LRFTAD 229 house mouse
AAL89965           244 KTFIY-DPDDTELLKMLPFLDA-LRFTKD 270 fruit fly
CAD25846           180 PPYTG-AEDDDSLLKILRFLEG-LPKDDL 206 Encephalitozoon cuniculi GB-M1
CAD51523           191 KKWQG-DLNDNELLHLIPFFLN-LRKLKD 217 Plasmodium falciparum 3D7
AAH52660           420 ESWFM-DKNDNELLKLIPFLEKlVELnED 447 house mouse
BAB63547           497 ESWFS-DDSDEALPQLIPFLETlASA-DD 523 Oryza sativa (japonica cultivar-group)
CAD71008           488 QGWIS-DPTDLDLMYLIPFLEG-LQYVSD 514 Neurospora crassa
XP_004471231       279 QSWFD-DMTDTELLDLIPFFEG-LSREDD 305 nine-banded armadillo
AAG10616           210 KAFVD-DLKDQELLNLVEFLES-CYAYED 236 thale cress
NP_191155          250 IAFSAgQPNDTQLLDVILPLLKqLSEEDD 278 thale cress
FlyBase:CG12078-PA 211 KSYEI-GCRDEALINLLPFLDA-LRFMKD 237 fruit fly
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