4RHN,1AV5,1KPE


Conserved Protein Domain Family
PKCI_related
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cd01276: PKCI_related 
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Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a hydrophobic residue) that is a signature for this family. No enzymatic activity has been reported however, for PKCI and its related members.
Links
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Statistics
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PSSM-Id: 238607
Aligned: 42 rows
Threshold Bit Score: 134.997
Created: 10-Jan-2006
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 10 residues -Click on image for an interactive view with Cn3D
Feature 1:nucleotide binding site/active site [active site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                # ##      # #                                          
4RHN          5 DTIFGKIIRKEIPAkIIFEDDQCLAFHDISPQAPTHFLVIPKKHIsqisaa----edadesLLGHLMIVGKKCAADlgl- 79  rabbit
AAG37984     19 DSIFGKIARGEVPVdAVYEDDKVIAFNDIYPQAPVHIIVIPKRRDgltrlsk--aeekhkeILGHLMWAVAEIVRKnn-- 94  Plasmodium falci...
Q23921       67 DTIFAKIISGAIPSkKFYDDEYCIAIEDINPQAPVHLLVIPKLAVgglsdvanvdlekykeSMGHIMSKIHHIASLkg-- 144 Dictyostelium di...
NP_295344    11 PTLFERIIAREIPSqVVYEDDDYIAIKDIAPKAPIHLLVIPKRVTtrvde------itdplEMGRLWLKATEIAREqa-- 82  Deinococcus radi...
NP_859560     4 KTIFEKIVAGEIPCkKVLENERFLAFYDINPKAPVHILAIPKVCVkdfdc-------adskLLGELCGFAQEVTKSvgi- 75  Helicobacter hep...
P56147        1 MNVFEKIIQGEIPCsKILENERFLSFYDINPKAKVHALVIPKQSIqdfng-------itpeLMAQMTSFIFEVVEKlgi- 72  Helicobacter pyl...
NP_282051     4 KTIFELIVEGKLPCnKVLESDDFLAFHDIAPKAPIHILIIPKKYFkdfqe-------fdpeLMAKMTSFIQELAVLlgv- 75  Campylobacter je...
Q9Z863        1 MTVFKQIIDGLIDCeKVFENENFIAIKDRFPQAPVHLLIIPKKPIprfqdi----pgdemiLMAEAGKIVQELAAEfgi- 75  Chlamydophila pn...
ZP_00030841   6 NCLFCKIAAGAIPStKVHEDDEFVAFRDIRPAAETHVLVIPRRHIatlsnc----tgsdapLLGRMLVLTARLADQlgva 81  Burkholderia fun...
NP_886404     4 NCIFCKIARGEIPAkKVFEDDEFVAFHDINPAAPVHLLLIPRRHVvslqdi----aegdadWLGRMTVLASRLAAGngcn 79  Bordetella parap...

Feature 1                   #      # #   # #    
4RHN         80 ----kkGYRMVVNEGSDGGQSVYHVHLHVLGG 107 rabbit
AAG37984     95 ----lgDFRLVVNNGPEACQSIYYLHLHILAK 122 Plasmodium falciparum 3D7
Q23921      145 ----adSYRLVINEGVLGQQSVRWLHIHIPWW 172 Dictyostelium discoideum
NP_295344    83 -----pDYRLVVNCGAGGGQMVFHTHIHILAG 109 Deinococcus radiodurans R1
NP_859560    76 ---dksGYRIITNIGADGGQEVPHLHLHILGG 104 Helicobacter hepaticus ATCC 51449
P56147       73 ---kekGYKLLTNVGKNAGQEVMHLHFHILSG 101 Helicobacter pylori J99
NP_282051    76 ---dksGYRLVTNCGKNSGQEVFHLHFHMLGG 104 Campylobacter jejuni subsp. jejuni NCTC 11168
Q9Z863       76 ----adGYRVVINNGAEGGQAVFHLHIHLLGG 103 Chlamydophila pneumoniae
ZP_00030841  82 ytggetGFRTVINTGPGGGQEVYHLHAHILAG 113 Burkholderia fungorum
NP_886404    80 p-gpdgGFRLMANSGAEGGQEVPHLHFHILGG 110 Bordetella parapertussis

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