5JRO,1DXQ,3F2V,3HA2


Conserved Protein Domain Family
Flavodoxin_2

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pfam02525: Flavodoxin_2 (this model, PSSM-Id:396879 is obsolete and has been replaced by 426816)
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Flavodoxin-like fold
This family consists of a domain with a flavodoxin-like fold. The family includes bacterial and eukaryotic NAD(P)H dehydrogenase (quinone) EC:1.6.99.2. These enzymes catalyze the NAD(P)H-dependent two-electron reductions of quinones and protect cells against damage by free radicals and reactive oxygen species. This enzyme uses a FAD co-factor. The equation for this reaction is:- NAD(P)H + acceptor <=> NAD(P)(+) + reduced acceptor. This enzyme is also involved in the bioactivation of prodrugs used in chemotherapy. The family also includes acyl carrier protein phosphodiesterase EC:3.1.4.14. This enzyme converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine residue from ACP. This family is related to pfam03358 and pfam00258.
Statistics
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PSSM-Id: 396879
Aligned: 243 rows
Threshold Bit Score: 65.0295
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5JRO_A         5 SKVLVLKSSILAtS-SQSNQLADFFVEQWQAAhagdQITVRDLAAQ-PIPVLDGELVGalrpsgTaLTPRQ---QeALAL 79  Yersinia pestis...
Q9ABF1         6 RRILILVGHPDPaPeRFCRALAEAYAQGAMEGg--hEVRRADIGSMdI-ALLE--------------SQAAfqvDdAPQS 68  Caulobacter vib...
EAP88920       3 KRICLINGHPDPsPeRFCHALTDAYQASAQEAg--hIVDRLDVGAMeF-GFL---------------SSPQefeTkPPAV 64  Oceanicaulis sp...
Q0ANW2         3 RSICIINGHPDGePeRFVAALCEAYAHGAVAGg--hAVSRIDIAGLpI-DFL---------------SSEAefaVaPGAE 64  Maricaulis mari...
WP_003728423   2 AKIVAIIGDPRE-K-GTSRDLFQKYLAVFQEQpt-iEVKIYDIRKLaFDPNLPE-------------GYRTe--QtPDII 63  Listeria monocy...
Q92AL9         2 AKVVAIMGDPREk--GTSRELFHKYLTFFQGHsa-ieIKTYDIRELaFDPNLPE-------------GYRTeqtT----E 61  Listeria innocua
ABN07907       1 MKITVIYGTNRTeK-SSTYNIARQFIEELADGd---tVTEFHLPRD--MPVFCTGCLTc-----L-SDSTK---CpHYKY 65  Methanocorpuscu...
ABN07897       1 MKITVIYGTSRTeK-SSTYNIAQQFLAELADGd---pVTEFHLPKD--MPEFCTGCFNc-----F-SDPAK---CpHYAY 65  Methanocorpuscu...
Q5WD38         1 MKVMALFGSARI-E-GNTEQLADIALRGINHRr-------IHLLKCgFDPIIDER------------HAPNgftAvNDGY 59  Bacillus clausi...
Q7WAP8         8 NPVLVLVGSPRRd--GNSALLAQAVAEGARQSg---aVATLLFLDD-YIAGFLTd---------E-KEAda--rRpDDRY 69  Bordetella para...
5JRO_A        80 SDEliAELQANDVIVIAAPMYNFNIPTQLKNYFDMIARAGVTFRYte----kGp-----EGLVt----GKRAIILTSRGG 146 Yersinia pestis...
Q9ABF1        69 IRDlrADIVWAEHLVLVFPLWLGGAPAKLKAALEQVCRGGFGFe--------VgprgwsSKLA-----GRSARMVLTMGM 135 Caulobacter vib...
EAP88920      65 FDPvrTAMSEADHLVLIYPLWLGEIPAKTKAFFEHAASGEFFLat-----saNgagwpsQRMK-----GKSARLIVTMGM 134 Oceanicaulis sp...
Q0ANW2        65 IVAaqEAILAADHLVLAYPLWLGTIPARLKAFLEQIGRAGFLLdt-----ggDshkwpvRRMR-----GKSVRIIVTMGM 134 Maricaulis mari...
WP_003728423  64 ALK--NDVRSADLLLFSYPVWWFNVPAVLKGVIDHLFWPGESYSFkd----kKyf--ltGPWR-----KKRARLIYTIGG 130 Listeria monocy...
Q92AL9        62 MTNlkQDASSADLLLFAYLVWWFNVPAVLKGVIDHLFWRGESYSFkd-----------kKYLLtgpwrKKRARLIYTIGG 130 Listeria innocua
ABN07907      66 VQPieEAMESADLIIFTTPVYLLHVPGQVKALLDHF-----GFQWma----hKp----kDVYF-----HKQALVISTGAR 127 Methanocorpuscu...
ABN07897      66 IKPisDAMLNADLIIISAPVYVFHMPGQVKALLDHF-----GYQWia----hRp----iEAFF-----HKQGLVITTAAG 127 Methanocorpuscu...
Q5WD38        60 KEVl-DDFLNQDIVLFVTPLYWFGMSGQMKGFFDRWSQYMQ-----------DqrlgfhERIR-----GKKAYVIVVGEN 122 Bacillus clausi...
Q7WAP8        70 GELffDHFLPARAVVLCTPVYWYGMSAQAKAFFDR------SFTYysashprHae--vlRRMT-----GKRLALAVSSEE 136 Bordetella para...
5JRO_A       147 I-HK----DtPTDLVVPY-LRLFLGFIGITDV----EFVF---AEGiAy-GPEVaTKAQADAKT-----L 197 Yersinia pestis CO92
Q9ABF1       136 PsAIfrl--vfgSHGLKAvTQGIFMLAGVKPR----RASIiggV-----------EAIGAGGRSrwlkrM 188 Caulobacter vibrioides
EAP88920     135 PgFAykl--ifgAHSLKAlEAGLLKISGFKPV----RHTVfggV------------QISEKSRLsmlekT 186 Oceanicaulis sp. HTCC2633
Q0ANW2       135 PgFAyrl--lfgAHSLKGlEAGIFRMSGFSPV----RHTIfggV-----------GACGPDGRQamldrV 187 Maricaulis maris MCS10
WP_003728423 131 MeIQhrlfA---RPALTA-LRYPLWMSGVFSV----KVTS---IDRl--------DLSIRRTDDyydkkV 181 Listeria monocytogenes
Q92AL9       131 MeLq----HrLFARPALTaLRYPLWMSGVLSV----RAT-----------SIDRlDLSIRKSNEyydkkI 181 Listeria innocua
ABN07907     128 I---------GIRQTVRD-VRNSLDWWGVGRIyrfkKTVG---MKGwRglSDKRkAAFAQEIKQtskkiR 184 Methanocorpusculum labrea...
ABN07897     128 A---------GMRHAAKD-AQDSFNWWGVGRTytfkKAVQ---ASEwSqvSEKKrEKITKEVKAtsrkiL 184 Methanocorpusculum labrea...
Q5WD38       123 PhPRia-----alPLIQQ-FHAIFEYTGMEFS----DYII---GKGnR--PGTIkQDQLALEKAdfwnkT 177 Bacillus clausii KSM-K16
Q7WAP8       137 Ty-----pGaALGIVHQ--LQEFTRYTHSQFV----GMVH---GAGnRrgEVAHdPRRPLQAAHrlghgL 192 Bordetella parapertussis
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